Background: Comorbidities affect outcomes in heart failure (HF), but are not reflected in current HF classification. The aim of this study is to characterize HF groups that account for higher-order interactions between comorbidities and to investigate the association between comorbidity groups and outcomes. Methods: Latent class analysis [LCA] was ...
Introduction UK Guidelines suggest pulse oximetry, rather than blood gas sampling, is adequate for monitoring of patients with COVID-19 if CO2 retention is not suspected. However, pulse oximetry has impaired accuracy in certain patient groups, and data are lacking on its accuracy in patients with COVID-19 stepping down from Intensive Care Units (IC...
Background Integrated community case management (iCCM) is a programme that can, via community health workers (CHWs), increase access to timely and essential treatments for children. As well as improving treatment coverage, iCCM has an additional equity-focus with the aim of targeting underserved populations. To assess the success of iCCM programmes...
Background The diagnosis of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) relies on characteristic clinical features synthesized as the International Network for the Study of HIV-associated IRIS (INSHI) case definition. There is no confirmatory laboratory test. Setting Site B HIV-TB clinic in Khayelitsha,...
The world is getting closer, enabling far-ranging human movements as well as disease diffusions (1). This greater interconnectedness has drawn our attention to a core feature of the real world—the “small-world” characteristic (2). Thinking from a network perspective, the world consists of closely connected communities which are bridged by random, l...
Objective: The aim of the COVER Study is to identify global outcomes and decision making for vascular procedures during the pandemic. Background data: During its initial peak, there were many reports of delays to vital surgery and the release of several guidelines advising later thresholds for vascular surgical intervention for key conditions. Meth...
Background Progress in characterising the humoral immune response to Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) has been rapid but areas of uncertainty persist. Assessment of the full range of evidence generated to date to understand the characteristics of the antibody response, its dynamics over time, its determinants and the immunity it con...
Between April and September 2017 in the final stages of the Cassini Saturn Orbiter mission the spacecraft executed 22 orbits passing planetward of the innermost ring, the D-ring. During periapsis passes on all these orbits oscillations were detected in the azimuthal magnetic field components on typical time scales from a few minutes to 10 minutes. ...
We present the results of a new, deeper, and complete search for high-redshift $6.5
