Han, Sichong Wang, Zhe Liu, Jining Yuan, Qipeng
Published in
International journal of molecular sciences
Understanding the mechanism by which sulforaphene (SFE) affects esophageal squamous cell carcinoma (ESCC) contributes to the application of this isothiocyanate as a chemotherapeutic agent. Thus, we attempted to investigate SFE regulation of ESCC characteristics more deeply. We performed gene set enrichment analysis (GSEA) on microarray data of SFE-...
Hill, Aileen Heyland, Daren K Rossaint, Rolf Arora, Rakesh C Engelman, Daniel T Day, Andrew G Stoppe, Christian
Published in
Journal of clinical medicine
Cardiac surgery (CSX) can be lifesaving in elderly patients (age ≥ 80 years) but may still be associated with complications and functional decline. Frailty represents a determinant to outcomes in critically ill patients, but little is known about its influence on elderly CSX-patients. This is a secondary exploratory analysis of a multi-center, pros...
Knock, E Whittles, L Lees, J Perez Guzman, P Verity, R Fitzjohn, R Gaythorpe, K Imai, N Hinsley, W Okell, L
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England has been severely affected by COVID-19. We fitted a model of SARS-CoV-2 transmission in care homes and the community to regional 2020 surveillance data. Only national lockdown brought the reproduction number below 1 consistently; introduced one week earlier in the first wave it could have reduced mortality by 23,300 deaths on average. The m...
Post, N Eddy, D Huntley, C Van Schalkwyk, MCI Shrotri, M Leeman, D Rigby, S Williams, SV Bermingham, WH Kellam, P
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Introduction Progress in characterising the humoral immune response to Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) has been rapid but areas of uncertainty persist. This review comprehensively evaluated evidence describing the antibody response to SARS-CoV-2 published from 01/01/2020-26/06/2020. Methods Systematic review. Keyword-structured sea...
Williams, AGL Karapetsas, G Mamalis, D Sefiane, K Matar, OK Valluri, P
Abstract
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Mulakkal, M Castillo Castillo, A Taylor, A Blackman, B Balint, D Pimenta, S Charalambides, M
Plastics are attracting negative publicity due to the scale of current pollution levels, yet they are irreplaceable in several applications such as food packaging, where different types of plastics are combined in laminate form to produce multilayered packaging (MLP) materials which extend the life of food items packaged within them. Increased plas...
Sedgwick, R Goertz, J Stevens, M Misener, R Wilk, MVD
There is a growing trend in molecular and synthetic biology of using mechanistic (non machine learning) models to design biomolecular networks. Once designed, these networks need to be validated by experimental results to ensure the theoretical network correctly models the true system. However, these experiments can be expensive and time consuming....
Tiseo, Katie Huber, Laura Gilbert, Marius Robinson, Timothy P Van Boeckel, Thomas P
Published in
Antibiotics (Basel, Switzerland)
Demand for animal protein is rising globally and has been facilitated by the expansion of intensive farming. However, intensive animal production relies on the regular use of antimicrobials to maintain health and productivity on farms. The routine use of antimicrobials fuels the development of antimicrobial resistance, a growing threat for the heal...
Fu, H Lewnard, JA Frost, I Laxminarayan, R Arinaminpathy, N
Al-Khayatt, B Salciccioli, J Marshall, D Krahn, A Shalhoub, J Sikkel, M
Aims: To understand the changing trends in Atrial Fibrillation (AF) incidence and mortality across Europe from 1990 to 2017, and how socioeconomic factors and sex differences play a role. Methods and Results: We performed a temporal analysis of data from the 2017 Global Burden of Disease Database for 20 countries across Europe using Joinpoint regre...
