The use of unsymmetrical components in metallo-supramolecular chemistry allows for low- symmetry architectures with anisotropic cavities toward guest-binding with high specificity and affinity. Unsymmetrical ditopic ligands mixed with Pd(II) have the potential to self-assemble into reduced symmetry Pd 2 L 4 metallo-architectures. Mixtures of isomer...
Progesterone (P4) and cyclic adenosine monophosphate (cAMP) are regarded as pro-quiescent factors that suppress uterine contractions during pregnancy. We previously used human primary cells in vitro and mice in vivo to demonstrate that simultaneously enhancing myometrial P4 and cAMP levels may reduce inflammation-associated preterm labor. Here, we ...
Published in Annals of surgery
To discover serum-based microRNA (miRNA) biomarkers for small-bowel neuroendocrine tumors (SBNET) to help guide clinical decisions. MiRNAs are small noncoding RNA molecules implicated in the initiation and progression of many cancers. MiRNAs are remarkably stable in bodily fluids, and can potentially be translated into clinically useful biomarkers....
In today's increasingly heterogeneous compute landscape, there is high demand for design tools that offer seemingly contradictory features: portable programming abstractions that hide underlying architectural detail, and the capability to optimise and exploit architectural features. Our meta-programming approach, Artisan, decouples application func...
The Sustainable Development Goals (SDGs) were launched in 2016 to expand the 2000 Millennium Development Goals. SDG-5 calls on governments to achieve gender equality and empowerment of all girls, highlighting the importance of sexual and reproductive health (SRH). There are large variations across the globe in maternity safety and there is clear ev...
Robot modelling is an essential part to properly understand how a robotic system moves and how to control it. The kinematic model of a robot is usually obtained by using Denavit-Hartenberg convention, which relies on a set of parameters to describe the end-effector pose in a Cartesian space. These parameters are assigned based on geometrical consid...
In robotically assisted surgical procedures the surgical tool is usually inserted in the patient’s body through a small incision, which acts as a constraint for the motion of the robot, known as remote center of Motion (RCM). The location of the insertion point on the patient’s body has huge effects on the performances of the surgical robot. In thi...
Most state-of-the-art bipedal robots are designed to be anthropomorphic, and therefore possess articulated legs with knees. Whilst this facilitates smoother, human-like locomotion, there are implementation issues that make walking with straight legs difficult. Many robots have to move with a constant bend in the legs to avoid a singularity occurrin...
The COVID-19 pandemic and associated travel restrictions have created an unprecedented challenge for the air transport industry, which before the pandemic was facing almost the exact opposite set of problems. Instead of the growing demand and need for capacity expansion warring against environmental concerns, the sector is now facing a slump in dem...
The major obstacle in applying peptides to intracellular targets is their low inherent cell permeability. Standard approaches to attach a fluorophore (e.g. FITC, TAMRA) can change the physicochemical properties of the parent peptide and influence their ability to penetrate and localize in cells. We report a label-free strategy for evaluating the ce...
