Leducq, Valentin Jary, Aude Bridier-Nahmias, Antoine Daniel, Lena Zafilaza, Karen Damond, Florence Goldstein, Valérie Duval, Audrey Blanquart, François Calvez, Vincent
...
Published in
Scientific Reports
France went through three deadly epidemic waves due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing major public health and socioeconomic issues. We proposed to study the course of the pandemic along 2020 from the outlook of two major Parisian hospitals earliest involved in the fight against COVID-19. Genome sequencing ...
St-Onge, Guillaume Iacopini, Iacopo Latora, Vito Barrat, Alain Petri, Giovanni Allard, Antoine Hébert-Dufresne, Laurent
Published in
Communications Physics
Group interactions can dramatically alter social contagion dynamics and lead to the emergence of new phenomena like abrupt transitions and critical mass effects. The authors develop an approximate master equation framework to analytically describe contagion in heterogeneous hypergraphs and study the impact of large influential groups in seeding and...
Bijoux, Wendy Cordina-Duverger, Emilie Balbolia, Soumaya Lamy, Pierre-Jean Rebillard, Xavier Tretarre, Brigitte Cenee, Sylvie Menegaux, Florence
Published in
Journal of Occupational Medicine and Toxicology
BackgroundAlthough prostate cancer (PCa) is the most frequent male cancer in industrialized countries, little is known about its aetiology. The literature has suggested an influence of the environment, including occupational exposures, but results are inconsistent. In this context, we investigated PCa risk associated to employment among several occ...
Martin, Ludovic Kaci, Nabil Benoist-Lasselin, Catherine Mondoloni, Marine Decaudaveine, Suzanne Estibals, Valentin Cornille, Maxence Loisay, Léa Flipo, Justine Demuynck, Benoît
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Published in
Bone Research
A gain-of-function mutation in the fibroblast growth factor receptor 3 gene (FGFR3) results in achondroplasia (ACH), the most frequent form of dwarfism. Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways. Identification of new and relevant compounds targeting the FGFR3 signaling pathway is o...
Grasset, Romain Katsumi, Kota Massat, Pierre Wen, Hai-Hu Chen, Xian-Hui Gallais, Yann Shimano, Ryo
Published in
npj Quantum Materials
We investigate the collective mode response of the iron-based superconductor Ba1−xKxFe2As2 using intense terahertz (THz) light. In the superconducting state a THz Kerr signal is observed and assigned to nonlinear THz coupling to superconducting degrees of freedom. The polarization dependence of the THz Kerr signal is remarkably sensitive to the coe...
Claireaux, Mathieu Robinot, Rémy Kervevan, Jérôme Patgaonkar, Mandar Staropoli, Isabelle Brelot, Anne Nouël, Alexandre Gellenoncourt, Stacy Tang, Xian Héry, Mélanie
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Published in
Nature Communications
Here, Claireaux et al. show that people who naturally control HIV infection express lower levels of the viral co-receptor CCR5 in specific CD4+ T cells, and that this results from mutations or receptor internalization by CD4+ T cell-produced chemokines.
Su, Li Hôtel, Laurence Paris, Cédric Chepkirui, Clara Brachmann, Alexander O. Piel, Jörn Jacob, Christophe Aigle, Bertrand Weissman, Kira J.
Published in
Nature Communications
Genetic engineering of the type I polyketide synthases (PKSs) to produce desirable analogous remains largely inefficient. Here, the authors leverage multiple approaches to delete seven internal modules from the stambomycin PKS and generate 37-membered mini-stambomycin macrolactones.
Ahongo, Yéléhi-Diane Le Cam, Aurélie Montfort, Jérôme Bugeon, Jérôme Lefèvre, Florence Rescan, Pierre-Yves
Published in
BMC Genomics
Background Sexual maturation causes loss of fish muscle mass and deterioration of fillet quality attributes that prevent market success. We recently showed that fillet yield and flesh quality recover in female trout after spawning. To gain insight into the molecular mechanisms regulating flesh quality recovery, we used an Agilent-based microarray p...
Pereira, Gonçalo Guo, Yongzhi Silva, Elisabete Bevilacqua, Claudia Charpigny, Gilles Lopes-da-Costa, Luís Humblot, Patrice
Published in
BMC Genomics
BackgroundThe endometrium is a heterogeneous tissue composed of luminal epithelial (LE), glandular epithelial (GE), and stromal cells (ST), experiencing progesterone regulated dynamic changes during the estrous cycle. In the cow, this regulation at the transcriptomic level was only evaluated in the whole tissue. This study describes specific gene e...
Saridakis, Emmanuel Vishwakarma, Rishi Lai-Kee-Him, Josephine Martin, Kevin Simon, Isabelle Cohen-Gonsaud, Martin Coste, Franck Bron, Patrick Margeat, Emmanuel Boudvillain, Marc
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Published in
Communications Biology
Cryo-EM shows that M. tuberculosis Rho-factor adopts an open, ring-shaped hexamer conformation and a steric bulk in the cavity for bicyclomycin binding, which explains resistance to the antibiotic.
