Lim, Hyungsik Danias, John
Published in
Journal of Biomedical Optics
Many studies suggest that the degradation of microtubules in the retinal ganglion cells may be an early event in the progression of glaucoma. Because reflectance and birefringence of the retinal nerve fibers arise primarily from microtubules, the optical properties have been intensively studied for early detection of the disease. We previously repo...
Jo, Janggun Zhang, Hongyu Cheney, Paul D. Yang, Xinmai
Published in
Journal of Biomedical Optics
Photoacoustic (PA) imaging was applied to detect the neuronal activity in the motor cortex of an awake, behaving monkey during forelimb movement. An adult macaque monkey was trained to perform a reach-to-grasp task while PA images were acquired through a 30-mm diameter implanted cranial chamber. Increased PA signal amplitude results from an increas...
Deán-Ben, X. Luís Ntziachristos, Vasilis Razansky, Daniel
Published in
Journal of Biomedical Optics
The quality of optoacoustic tomographic reconstructions can be severely affected by acoustic reflections or scattering arising at interfaces of highly mismatched organs, such as bones, lungs, or other air-containing cavities. We present a procedure to reduce the associated artefacts based on estimation of the acoustic scatterers distribution within...
Monteiro, Andréa M. Jardini, Maria A. N. Giampaoli, Viviana Alves, Sarah Figueiredo Neto, Antônio M. Gidlund, Magnus
Published in
Journal of Biomedical Optics
The Z-Scan (ZS) technique in the thermal regime has been used to measure the nonlinear optical response of low-density lipoprotein (LDL). The ZS technique is carried out in LDL from 40 patients with chronic periodontitis before and after three, six, and 12 months of periodontal treatment. Clinical parameters such as probing depths, bleeding on prob...
Nie, Liming Cai, Xin Maslov, Konstantin Garcia-Uribe, Alejandro Anastasio, Mark A. Wang, Lihong V.
Published in
Journal of Biomedical Optics
Photoacoustic tomography (PAT) of the human brain is challenging due to the fact that the skull strongly absorbs and scatters light, and attenuates and distorts ultrasound as well. For the first time, we demonstrated the feasibility of PAT through a whole adult human skull. A photon recycler (PR) was built to increase light transmittance through th...
Parashurama, Natesh O’Sullivan, Thomas D. De La Zerda, Adam El Kalassi, Pascale Cho, Seongjae Liu, Hongguang Teed, Robert Levy, Hart Rosenberg, Jarrett Cheng, Zhen
...
Published in
Journal of Biomedical Optics
Molecular optical imaging is a widespread technique for interrogating molecular events in living subjects. However, current approaches preclude long-term, continuous measurements in awake, mobile subjects, a strategy crucial in several medical conditions. Consequently, we designed a novel, lightweight miniature biosensor for in vivo continuous opti...
Kang, Hyun Wook Kim, Jeehyun Oh, Jungwhan
Published in
Journal of Biomedical Optics
A novel balloon catheter-based diffusing optical device was designed and evaluated to assist in treating excessive menstrual bleeding. A synthetic fused-silica fiber was micro-machined precisely to create scattering segments on a 25 mm long fiber tip for uniform light distribution. A visible wavelength (λ=532 nm) was used to specifically target the...
Wijshoff, Ralph W. C. G. R. Mischi, Massimo Veen, Jeroen van der Lee, Alexander M. Aarts, Ronald M.
Published in
Journal of Biomedical Optics
Currently, photoplethysmograms (PPGs) are mostly used to determine a patient’s blood oxygenation and pulse rate. However, PPG morphology conveys more information about the patient’s cardiovascular status. Extracting this information requires measuring clean PPG waveforms that are free of artifacts. PPGs are highly susceptible to motion, which can d...
Ren, YongJie Yin, ShiBin Zhu, JiGui
Published in
Optical Engineering
A system composed of laser sensor and 6-DOF industrial robot is proposed to obtain complete three-dimensional (3-D) information of the object surface. Suitable for the different combining ways of laser sensor and robot, a new method to calibrate the position and pose between sensor and robot is presented. By using a standard sphere with known radiu...
Sun, An Wu, Zhishen
Published in
Optical Engineering
In this paper, a simple and practical method based on multimode fiber (MMF)–single mode chirped fiber Bragg grating (CFBG) structures for highly sensitive bending measurement is proposed. By employing the wide wavelength resonance of CFBG, enhanced backward cladding modes can be achieved through the coupling and recoupling between MMF and CFBG. Exp...
