Targeting HER2 in Biliary Tract Carcinomas: Challenges and Opportunities
Published in Oncology Research and Treatment
Influence of Including Patients with Premorbid Disability in Acute Stroke Trials: The HeadPoST Experience
...Published in Cerebrovascular Diseases
Background: Patients with premorbid functional impairment are generally excluded from acute stroke trials. We aimed to determine the impact of including such patients in the Head Positioning in acute Stroke Trial (HeadPoST) and early additional impairment on outcomes. Methods: Post hoc analyses of HeadPoST, an international, cluster-randomized cros...
Elevation of Urate in Saliva and Serum of Patients with Knee Osteoarthritis
Published in Gerontology
Background: Knee osteoarthritis (knee OA) is the most common joint disease and the leading cause of disability and has a considerable financial burden on the healthcare system. Objective: The aim of the present study was to evaluate urate in saliva and serum of knee OA. Methods: Serum and saliva urate levels of 30 knee OA and 30 healthy controls we...
Event-Based but Not Time-Based Prospective Memory Is Related to Oral Health in Late Adulthood
Published in Gerontology
Background: Most evidence now indicates that cognitive function is related to poorer oral health in late adulthood, but that this relationship is not invariant across specific cognitive domains. Prospective memory (PM) is a core memory skill that refers to memory for future intentions and is known to be related to the formation of habits such as to...
Pathobiological Subtypes of Alzheimer Disease
Published in Dementia and Geriatric Cognitive Disorders
Alzheimer disease (AD), the most common form of dementia, is a heterogenous disorder with various pathobiological subtypes. In addition to the 4 major subtypes based on the distribution of tau pathology and brain atrophy (typical, limbic predominant, hippocampal sparing, and minimal atrophy [MA]), several other clinical variants showing distinct re...
Atopische Dermatitis: Kombination aus Dupilumab und Kortikosteroid auch bei 6- bis 11-Jährigen erfolgreich
Published in Kompass Dermatologie
Background: Children with severe atopic dermatitis (AD) have limited treatment options. Objective: We report the efficacy and safety of dupilumab + topical corticosteroids (TCS) in children aged 6–11 years with severe AD inadequately controlled with topical therapies. Methods: In this double-blind, 16-week, phase 3 trial (NCT03345914), 367 patients...
Predictors of Frailty and Vitality in Older Adults Aged 75 years and Over: Results from the Longitudinal Aging Study Ams...
Published in Gerontology
Introduction: Frailty can be seen as a continuum, from fit to frail. While many recent studies have focused on frailty, much less attention has been paid to the other end of the continuum: the group of older adults that remain (relatively) vital. Moreover, there is a lack of studies on frailty and vitality that investigate predictors from multiple ...
Relationship between Apgar Scores and Morbidity and Mortality Outcomes in Preterm Infants: A Single-Centre Cohort Study
Published in Neonatology
Introduction: Apgar scoring in modern practice has extended beyond the original described remit by Virginia Apgar, including prognostication. Prognostic value of Apgar scoring in preterm populations is unsupported by robust evidence. Objectives: We aimed to identify the association between mortality or a composite mortality/major morbidity outcome ...
Transhumanismus: Welchen Menschen wollen wir?
Published in Kompass Dermatologie
Knowledge of Stroke Risk Factors and Signs in Parakou, a Northern City of Benin in West Africa
Published in Cerebrovascular Diseases
Introduction: We aimed to determine knowledge of stroke risk factors and signs in an urban population of northern Benin. Methods: A door-to-door purposeful sampling survey was conducted in resident population (age ≥15 years) of the district of Titirou in the city of Parakou (N = 255,478) in Benin between March 15 and July 15, 2016. In-person interv...
