Carobene, Anna Kilpatrick, Eric Bartlett, William A. Fernández Calle, Pilar Coşkun, Abdurrahman Díaz-Garzón, Jorge Jonker, Niels Locatelli, Massimo Sandberg, Sverre Aarsand, Aasne K.
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Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives An insulin resistant state is characteristic of patients with type 2 diabetes, polycystic ovary syndrome, and metabolic syndrome. Identification of insulin resistance (IR) is most readily achievable using formulae combining plasma insulin and glucose results. In this study, we have used data from the European Biological Variation Study (...
Hannich, Malte J. Konen, Franz F. Gag, Konrad Alkhayer, Aiham Türker, Seda N. Budde, Kathrin Nauck, Matthias Wurster, Ulrich Dressel, Alexander Skripuletz, Thomas
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Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Oligoclonal bands (OCB) analysis is the reference standard for detecting an intrathecal IgG synthesis. Alongside OCB, free light chains kappa (FLCκ) are considered an additional sensitive biomarker for determining patterns 2 or 3, indicating intrathecal Ig synthesis. However, kFLC IF is not suitable for detecting a monoclonal pattern 5. ...
Prenzel, Freerk Kaiser, Thorsten Willenberg, Anja vom Hove, Maike Flemming, Gunter Fischer, Lars Kratzsch, Jürgen Kiess, Wieland Vogel, Mandy
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Soluble transferrin receptor (sTfR) is a marker of both erythropoiesis and iron status and is considered useful for detecting iron deficiency, especially in inflammatory conditions, but reference intervals covering the entire pediatric age spectrum are lacking. Methods We studied 1,064 (48.5 % female) healthy children of the entire pedia...
Chévrier, Marc Frugier, Audrey Colognac, Sylvie Monneret, Denis
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Clerico, Aldo Zaninotto, Martina Aimo, Alberto Galli, Claudio Sandri, Maria Teresa Correale, Mario Dittadi, Ruggero Migliardi, Marco Fortunato, Antonio Belloni, Lucia
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Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
The first part of this Inter-Society Document describes the mechanisms involved in the development of cardiovascular diseases, particularly arterial hypertension, in adults and the elderly. It will also examine how consistent physical exercise during adolescence and adulthood can help maintain blood pressure levels and prevent progression to sympto...
Lippi, Giuseppe Akhvlediani, Salome Cadamuro, Janne Danese, Elisa García de Guadiana Romualdo, Luis Delacour, Herve Favaloro, Emmanuel J. Favresse, Julien Henry, Brandon M. Jovicic, Snezana
...
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
The healthcare systems are a prime target for cyber-attacks due to the sensitive nature of the information combined with the essential need for continuity of care. Medical laboratories are particularly vulnerable to cyber-attacks for a number of reasons, including the high level of information technology (IT), computerization and digitization. Base...
Žigon, Polona Boštic, Nika Ambrožič, Aleš Rotar, Žiga Blokar, Elizabeta Ogrič, Manca Čučnik, Saša
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Recently published 2023 ACR/EULAR APS classification criteria emphasize the importance of quantifying single-, double-, and triple-antiphospholipid antibody positivity, distinguishing between IgG and IgM isotypes, and delineating moderate/high levels of anticardiolipin (aCL) and anti-β2 glycoprotein I (anti-β2GPI) antibodies. We aimed to...
Plebani, Mario Nichols, James H. Luppa, Peter B. Greene, Dina Sciacovelli, Laura Shaw, Julie Khan, Adil I. Carraro, Paolo Freckmann, Guido Dimech, Wayne
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Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Point-of-care testing (POCT) is becoming an increasingly popular way to perform laboratory tests closer to the patient. This option has several recognized advantages, such as accessibility, portability, speed, convenience, ease of use, ever-growing test panels, lower cumulative healthcare costs when used within appropriate clinical pathways, better...
Michaelis, Simon Hochfellner, Anna Schneider, Christopher Schnedl, Wolfgang J. Baranyi, Andreas Enko, Dietmar
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Fecal calprotectin (FC) serves as a non-invasive marker for the assessment of gut inflammation in patients with inflammatory bowel disease (IBD). Laboratory measurements are usually performed with immunologic methods like enzyme-linked immunosorbent assay. Recently, quantitative home tests based on the lateral flow technology with smartp...
Huo, Xiaoyan Lu, Xinyi Lu, Deyun Liu, Huili Liu, Yi Zhao, Qianfeng Sun, Yu Dai, Weiqian Qiu, Wenjuan Yu, Yongguo
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Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Regions of homozygosity (ROH) could implicate uniparental disomy (UPD) on specific chromosomes associated with imprinting disorders. Though the algorithms for ROH detection in exome sequencing (ES) have been developed, optimal reporting thresholds and when to pursue confirmatory UPD testing for imprinting disorders remain in ambiguity. T...
