Groenen, M A Timmers, E van de Putte, P
Published in
Proceedings of the National Academy of Sciences
We have determined the minimal DNA sequences at the ends of the genome of bacteriophage Mu that are required for its transposition. A mini-Mu was constructed on a multicopy plasmid that enabled the manipulation of the DNA sequences at its ends without affecting the genes essential for transposition. The genes A and B, which were cloned outside the ...
Krystal, M Li, R Lyles, D Pavlakis, G Palese, P
Published in
Proceedings of the National Academy of Sciences
Transformed cell lines derived from murine C127 cells were constructed that express the influenza virus RNA-dependent RNA polymerase proteins (PA, PB1, and PB2). Cell lines that express only one or all three of the proteins were tested for their ability to complement temperature-sensitive viral mutants incubated at the nonpermissive temperature. Tw...
Bowtell, D Fu, P Simon, M Senior, P
Published in
Proceedings of the National Academy of Sciences
Several findings suggest that signals from tyrosine kinases are transduced, at least in part, through ras proteins. These findings include (i) blockage of the transforming activity of constitutively active tyrosine kinases by inhibiting ras function and (ii) genetic screens in Caenorhabditis elegans and in Drosophila that identified ras genes as do...
P. S. Gill larson reever R. Masood J. Cai T. Zheng D. L. Smith Y. Naidu
Published in
Proceedings of the National Academy of Sciences
R. Yamanaka G.-D. Kim H. S. Radomska J. Lekstrom-Himes L. T. Smith P. Antonson D. G. Tenen K. G. Xanthopoulos larson reever
Published in
Proceedings of the National Academy of Sciences
Morales, J Homey, B Vicari, A P Hudak, S Oldham, E Hedrick, J Orozco, R Copeland, N G Jenkins, N A McEvoy, L M
...
Published in
Proceedings of the National Academy of Sciences
In contrast to naive lymphocytes, memory/effector lymphocytes can access nonlymphoid effector sites and display restricted, often tissue-selective, migration behavior. The cutaneous lymphocyte-associated antigen (CLA) defines a subset of circulating memory T cells that selectively localize in cutaneous sites mediated in part by the interaction of C...
A Ploghaus I Tracey S Clare JS Gati JN Rawlins PM Matthews
Published in
Proceedings of the National Academy of Sciences
Associative learning is thought to depend on detecting mismatches between actual and expected experiences. With functional magnetic resonance imaging (FMRI), we studied brain activity during different types of mismatch in a paradigm where contrasting-colored lights signaled the delivery of painful heat, nonpainful warmth, or no stimulation. When pa...
Chyba, Christopher F Phillips, Cynthia B
Published in
Proceedings of the National Academy of Sciences
Stoddart, J. F. Hsian-Rong Tseng
Published in
Proceedings of the National Academy of Sciences
Gabriele Toietta V. P. Mane W.S. Norona M.J. Finegold P. Ng A.F. McDonagh A.L. Beaudet B. Lee
Published in
Proceedings of the National Academy of Sciences
Crigler-Najjar syndrome is a recessively inherited disorder characterized by severe unconjugated hyperbilirubinemia caused by a deficiency of uridine diphospho-glucuronosyl transferase 1A1. Current therapy relies on phototherapy to prevent kernicterus, but liver transplantation presently is the only permanent cure. Gene therapy is a potential alter...
