Tudor, Daniela Yu, Huifeng Maupetit, Julien Drillet, Anne-Sophie Bouceba, Tahar Schwartz-Cornil, Isabelle Lopalco, Lucia Pierre Tuffery Morgane Bomsel
Published in
Proceedings of the National Academy of Sciences
The constant heavy chain (CH1) domain affects antibody affinity and fine specificity, challenging the paradigm that only variable regions contribute to antigen binding. To investigate the role of the CH1 domain, we constructed IgA2 from the broadly neutralizing anti-HIV-1 2F5 IgG1, and compared 2F5 IgA2 and IgG binding affinity and functional activ...
Durand, Aurélie Donahue, Bridgitte Peignon, Grégory Letourneur, Franck Cagnard, Nicolas Slomianny, Christian Christine Perret Shroyer, Noah F Romagnolo, Béatrice
Published in
Proceedings of the National Academy of Sciences
Intestinal epithelium has the capacity to self-renew and generate differentiated cells through the existence of two types of epithelial stem cells: active crypt base columnar cells (CBCs) and quiescent +4 cells. The behaviors of these cells are regulated both by intrinsic programs and by extrinsic signals sent by neighboring cells, which define the...
Denissenko, Petr Kantsler, Vasily Smith, David J Kirkman-Brown, Jackson
Published in
Proceedings of the National Academy of Sciences
The migratory abilities of motile human spermatozoa in vivo are essential for natural fertility, but it remains a mystery what properties distinguish the tens of cells which find an egg from the millions of cells ejaculated. To reach the site of fertilization, sperm must traverse narrow and convoluted channels, filled with viscous fluids. To elucid...
Borucki, William J Boss, Alan P Ciardi, David R Quinn, Samuel N Steffen, Jason H Ragozzine, Darin Fabrycky, Daniel C Carter, Joshua A Ford, Eric B Holman, Matthew J
...
Published in
Proceedings of the National Academy of Sciences
Cartault, François Munier, Patrick Benko, Edgar Desguerre, Isabelle Hanein, Sylvain Boddaert, Nathalie Bandiera, Simonetta Vellayoudom, Jeanine Krejbich-Trotot, Pascale Bintner, Marc
...
Published in
Proceedings of the National Academy of Sciences
The human genome is densely populated with transposons and transposon-like repetitive elements. Although the impact of these transposons and elements on human genome evolution is recognized, the significance of subtle variations in their sequence remains mostly unexplored. Here we report homozygosity mapping of an infantile neurodegenerative diseas...
Kristensen, Vessela N Vaske, Charles J Ursini-Siegel, Josie Van Loo, Peter Nordgard, Silje H Sachidanandam, Ravi Sørlie, Therese Wärnberg, Fredrik Haakensen, Vilde D Helland, Åslaug
...
Published in
Proceedings of the National Academy of Sciences of the United States of America
We use an integrated approach to understand breast cancer heterogeneity by modeling mRNA, copy number alterations, microRNAs, and methylation in a pathway context utilizing the pathway recognition algorithm using data integration on genomic models (PARADIGM). We demonstrate that combining mRNA expression and DNA copy number classified the patients ...
Heiser, Laura M Sadanandam, Anguraj Kuo, Wen-Lin Benz, Stephen C Goldstein, Theodore C Ng, Sam Gibb, William J Wang, Nicholas J Ziyad, Safiyyah Tong, Frances
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Published in
Proceedings of the National Academy of Sciences of the United States of America
Breast cancers are comprised of molecularly distinct subtypes that may respond differently to pathway-targeted therapies now under development. Collections of breast cancer cell lines mirror many of the molecular subtypes and pathways found in tumors, suggesting that treatment of cell lines with candidate therapeutic compounds can guide identificat...
Chabbi-Achengli, Yasmine Coudert, Amélie E Callebert, Jacques Valérie Geoffroy Côté, Francine Collet, Corinne de Vernejoul, Marie-Christine
Published in
Proceedings of the National Academy of Sciences
Peripheral serotonin, synthesized by tryptophan hydroxylase-1 (TPH(1)), has been shown to play a key role in several physiological functions. Recently, controversy has emerged about whether peripheral serotonin has any effect on bone density and remodeling.We therefore decided to investigate in detail bone remodeling in growing and mature TPH(1) kn...
Raskatov, Jevgenij A Meier, Jordan L Puckett, James W Yang, Fei Ramakrishnan, Parameswaran Dervan, Peter B
Published in
Proceedings of the National Academy of Sciences of the United States of America
Nuclear factor κB (NF-κB) is a transcription factor that regulates various aspects of immune response, cell death, and differentiation as well as cancer. In this study we introduce the Py-Im polyamide 1 that binds preferentially to the sequences 5'-WGGWWW-3' and 5'GGGWWW-3'. The compound is capable of binding to κB sites and reducing the expression...
Huang, Zhi-ming Chinen, Milka Chang, Philip J Xie, Tong Zhong, Lily Demetriou, Stephanie Patel, Mira P Scherzer, Rebecca Sviderskaya, Elena V Bennett, Dorothy C
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Published in
Proceedings of the National Academy of Sciences of the United States of America
Protein-trafficking pathways are targeted here in human melanoma cells using methods independent of oncogene mutational status, and the ability to up-regulate and down-regulate tumor treatment sensitivity is demonstrated. Sensitivity of melanoma cells to cis-diaminedichloroplatinum II (cDDP, cis-platin), carboplatin, dacarbazine, or temozolomide to...
