Kepler constraints on planets near hot Jupiters
...Published in Proceedings of the National Academy of Sciences
Promiscuous binding of extracellular peptides to cell surface class I MHC protein.
...Published in Proceedings of the National Academy of Sciences
Algorithms derived from measurements of short-peptide (8-10 mers) binding to class I MHC proteins suggest that the binding groove of a class I MHC protein, such as K(b), can bind well over 1 million different peptides with significant affinity (
Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular...
...Published in Proceedings of the National Academy of Sciences of the United States of America
We use an integrated approach to understand breast cancer heterogeneity by modeling mRNA, copy number alterations, microRNAs, and methylation in a pathway context utilizing the pathway recognition algorithm using data integration on genomic models (PARADIGM). We demonstrate that combining mRNA expression and DNA copy number classified the patients ...
A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction
...Published in Proceedings of the National Academy of Sciences
Calorie restriction delays brain senescence and prevents neurodegeneration, but critical regulators of these beneficial responses other than the NAD(+)-dependent histone deacetylase Sirtuin-1 (Sirt-1) are unknown. We report that effects of calorie restriction on neuronal plasticity, memory and social behavior are abolished in mice lacking cAMP resp...
Micro-chemical synthesis of molecular probes on an electronic microfluidic device
...Published in Proceedings of the National Academy of Sciences
A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction
...Published in Proceedings of the National Academy of Sciences
A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction
Published in Proceedings of the National Academy of Sciences
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.
...Published in Proceedings of the National Academy of Sciences of the United States of America
Squamous cell carcinomas (SCCs) are one of the most frequent forms of human malignancy, but, other than TP53 mutations, few causative somatic aberrations have been identified. We identified NOTCH1 or NOTCH2 mutations in ~75% of cutaneous SCCs and in a lesser fraction of lung SCCs, defining a spectrum for the most prevalent tumor suppressor specific...
Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after sta...
...Published in Proceedings of the National Academy of Sciences
Approximately 8-20% of breast cancer patients receiving neoadjuvant chemotherapy fail to achieve a measurable response and endure toxic side effects without benefit. Most clinical and imaging measures of response are obtained several weeks after the start of therapy. Here, we report that functional hemodynamic and metabolic information acquired usi...
Demographic history and rare allele sharing among human populations.
Published in Proceedings of the National Academy of Sciences of the United States of America
High-throughput sequencing technology enables population-level surveys of human genomic variation. Here, we examine the joint allele frequency distributions across continental human populations and present an approach for combining complementary aspects of whole-genome, low-coverage data and targeted high-coverage data. We apply this approach to da...
