Grosse, Johannes Heffron, Helen Burling, Keith Akhter Hossain, Mohammed Habib, Abdella M Rogers, Gareth J Richards, Paul Larder, Rachel Rimmington, Debra Adriaenssens, Alice A
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Published in
Proceedings of the National Academy of Sciences
The gut endocrine system is emerging as a central player in the control of appetite and glucose homeostasis, and as a rich source of peptides with therapeutic potential in the field of diabetes and obesity. In this study we have explored the physiology of insulin-like peptide 5 (Insl5), which we identified as a product of colonic enteroendocrine L-...
Kistler, Logan Montenegro, Alvaro Smith, Bruce D Gifford, John A Green, Richard E Newsom, Lee A Shapiro, Beth
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Proceedings of the National Academy of Sciences of the United States of America
Bottle gourd (Lagenaria siceraria) was one of the first domesticated plants, and the only one with a global distribution during pre-Columbian times. Although native to Africa, bottle gourd was in use by humans in east Asia, possibly as early as 11,000 y ago (BP) and in the Americas by 10,000 BP. Despite its utilitarian importance to diverse human p...
Vozza, Angelo Parisi, Giovanni De Leonardis, Francesco Lasorsa, Francesco M Castegna, Alessandra Amorese, Daniela Marmo, Raffaele Calcagnile, Valeria M Palmieri, Luigi Ricquier, Daniel
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Published in
Proceedings of the National Academy of Sciences
Uncoupling protein 2 (UCP2) is involved in various physiological and pathological processes such as insulin secretion, stem cell differentiation, cancer, and aging. However, its biochemical and physiological function is still under debate. Here we show that UCP2 is a metabolite transporter that regulates substrate oxidation in mitochondria. To shed...
Djurisic, M. Vidal, G. S. Mann, M. Aharon, A. Kim, T. Ferrao Santos, A. Yi Zuo Hubener, M. Shatz, C. J.
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Proceedings of the National Academy of Sciences
Djurisic, M. Vidal, G. S. Mann, M. Aharon, A. Kim, T. Ferrao Santos, A. Yi Zuo Hubener, M. Shatz, C. J.
Published in
Proceedings of the National Academy of Sciences
Sánchez-Martín, David Martínez-Torrecuadrada, Jorge Teesalu, Tambet Sugahara, Kazuki N Alvarez-Cienfuegos, Ana Ximénez-Embún, Pilar Fernández-Periáñez, Rodrigo Martín, M Teresa Molina-Privado, Irene Ruppen-Cañás, Isabel
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Published in
Proceedings of the National Academy of Sciences of the United States of America
Antibody cancer therapies rely on systemically accessible targets and suitable antibodies that exert a functional activity or deliver a payload to the tumor site. Here, we present proof-of-principle of in vivo selection of human antibodies in tumor-bearing mice that identified a tumor-specific antibody able to deliver a payload and unveils the targ...
Vollmers, Christopher Sit, Rene V Weinstein, Joshua A Dekker, Cornelia L Quake, Stephen R
Published in
Proceedings of the National Academy of Sciences of the United States of America
Annual influenza vaccinations aim to protect against seasonal infections, and vaccine strain compositions are updated every year. This protection is based on antibodies that are produced by either newly activated or memory B cells recalled from previous encounters with influenza vaccination or infection. The extent to which the B-cell repertoire re...
Leppänen, Veli-Matti Tvorogov, Denis Kisko, Kaisa Prota, Andrea E Michael Jeltsch Anisimov, Andrey Markovic-Mueller, Sandra Stuttfeld, Edward Goldie, Kenneth N Ballmer-Hofer, Kurt
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Published in
Proceedings of the National Academy of Sciences
Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are key drivers of blood and lymph vessel formation in development, but also in several pathological processes. VEGF-C signaling through VEGFR-3 promotes lymphangiogenesis, which is a clinically relevant target for treating lymphatic insufficiency and for blocking tumor angiog...
H, Fukuyama Y, Verdier Y, Guan C, Makino-Okamura V, Shilova X, Liu E, Maksoud J, Matsubayashi I, Haddad K, Spirohn
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Published in
Proceedings of the National Academy of Sciences
The Drosophila defense against pathogens largely relies on the activation of two signaling pathways: immune deficiency (IMD) and Toll. The IMD pathway is triggered mainly by Gram-negative bacteria, whereas the Toll pathway responds predominantly to Gram-positive bacteria and fungi. The activation of these pathways leads to the rapid induction of nu...
Mao, Ping Joshi, Kaushal Li, Jianfeng Kim, Sung-Hak Li, Peipei Santana-Santos, Lucas Luthra, Soumya Chandran, Uma R Benos, Panayiotis V Smith, Luke
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Published in
Proceedings of the National Academy of Sciences of the United States of America
Tumor heterogeneity of high-grade glioma (HGG) is recognized by four clinically relevant subtypes based on core gene signatures. However, molecular signaling in glioma stem cells (GSCs) in individual HGG subtypes is poorly characterized. Here we identified and characterized two mutually exclusive GSC subtypes with distinct dysregulated signaling pa...