Published in Nature Communications
Sex differences in fasting glucose and insulin have been identified, but the genetic loci underlying these differences have not. Here, the authors perform a meta-analysis of genome-wide association studies to detect sex-specific and sex-dimorphic loci associated with fasting glucose and insulin.
Published in Scientific Reports
Circulating tumor DNA (ctDNA) has become an attractive biomarker in human oncology, and its use may be informative in canine cancer. Thus, we used droplet digital PCR or PCR for antigen receptor rearrangement, to explore tumor-specific point mutations, copy number alterations, and chromosomal rearrangements in the plasma of cancer-affected dogs. We...
Published in Nature Communications
Here the authors use Ramsey interferometry to study Tan’s contact in uniform two-dimensional Bose gas of 87Rb atoms across the Berezinskii–Kosterlitz–Thouless superfluid transition. They find that the two-body contact is continuous across the critical point.
Published in Nature Communications
Grasslands, and the livestock that live there, are dynamic sources and sinks of greenhouse gases, but what controls these fluxes remains poorly characterized. Here the authors show that on the global level, grasslands are climate neutral owing to the cancelling effects of managed vs. natural systems.
Published in Nature Communications
Temporal networks in which interaction events are distributed heterogeneously in time are complex to model. Unicomb et al. propose an analytical framework for the analysis of cascading dynamics in such networks, relevant for spin interactions, epidemic spreading, and language dynamics.
Published in Communications Biology
Gauvain et al demonstrate that optogenetic therapy using the AAV2.7m8- ChR-tdT construct can partially restore vision in non-human primates to levels above those considered legally-blind. This study enables the identification of the most suitable construct for ongoing clinical trials attempting vision restoration in patients with retinitis pigmento...
Published in Scientific Reports
Interactions between the hepatitis B virus core protein (HBc) and host cell proteins are poorly understood, although they may be essential for the propagation of the virus and its pathogenicity. HBc has a C-terminal PDZ (PSD-95, Dlg1, ZO-1)-binding motif (PBM) that is responsible for interactions with host PDZ domain-containing proteins. In this wo...
Published in Scientific Reports
Unlike variant Creutzfeldt–Jakob disease prions, sporadic Creutzfeldt–Jakob disease prions have been shown to be difficult to amplify in vitro by protein misfolding cyclic amplification (PMCA). We assessed PMCA of pathological prion protein (PrPTSE) from 14 human sCJD brain samples in 3 substrates: 2 from transgenic mice expressing human prion prot...
Published in Nature Communications
The origin of blue ejecta around the fresh craters of dwarf planet Ceres is unknown. Here, the authors show that the blue color results from high porosity of the surface, induced by sublimation of ice-phyllosilicate mixture produced by impacts.
Published in Nature Communications
Photochemistry of sulfur species in the upper Venus atmosphere is not well understood and the identity of ultraviolet (UV) absorber(s) remain unknown. Here, the authors show that sulfur monoxide dimer chemistry is a possible source of polysulfur, which could be responsible for the UV absorption.
