Lagou, Vasiliki Mägi, Reedik Hottenga, Jouke- Jan Grallert, Harald Perry, John R. B. Bouatia-Naji, Nabila Marullo, Letizia Rybin, Denis Jansen, Rick Min, Josine L.
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Published in
Nature Communications
Sex differences in fasting glucose and insulin have been identified, but the genetic loci underlying these differences have not. Here, the authors perform a meta-analysis of genome-wide association studies to detect sex-specific and sex-dimorphic loci associated with fasting glucose and insulin.
Prouteau, Anaïs Denis, Jérôme Alexandre De Fornel, Pauline Cadieu, Edouard Derrien, Thomas Kergal, Camille Botherel, Nadine Ulvé, Ronan Rault, Mélanie Bouzidi, Amira
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Published in
Scientific Reports
Circulating tumor DNA (ctDNA) has become an attractive biomarker in human oncology, and its use may be informative in canine cancer. Thus, we used droplet digital PCR or PCR for antigen receptor rearrangement, to explore tumor-specific point mutations, copy number alterations, and chromosomal rearrangements in the plasma of cancer-affected dogs. We...
Zou, Y.-Q. Bakkali-Hassani, B. Maury, C. Le Cerf, É. Nascimbene, S. Dalibard, J. Beugnon, J.
Published in
Nature Communications
Here the authors use Ramsey interferometry to study Tan’s contact in uniform two-dimensional Bose gas of 87Rb atoms across the Berezinskii–Kosterlitz–Thouless superfluid transition. They find that the two-body contact is continuous across the critical point.
Chang, Jinfeng Ciais, Philippe Gasser, Thomas Smith, Pete Herrero, Mario Havlík, Petr Obersteiner, Michael Guenet, Bertrand Goll, Daniel S. Li, Wei
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Published in
Nature Communications
Grasslands, and the livestock that live there, are dynamic sources and sinks of greenhouse gases, but what controls these fluxes remains poorly characterized. Here the authors show that on the global level, grasslands are climate neutral owing to the cancelling effects of managed vs. natural systems.
Unicomb, Samuel Iñiguez, Gerardo Gleeson, James P. Karsai, Márton
Published in
Nature Communications
Temporal networks in which interaction events are distributed heterogeneously in time are complex to model. Unicomb et al. propose an analytical framework for the analysis of cascading dynamics in such networks, relevant for spin interactions, epidemic spreading, and language dynamics.
Gauvain, Gregory Akolkar, Himanshu Chaffiol, Antoine Arcizet, Fabrice Khoei, Mina A. Desrosiers, Mélissa Jaillard, Céline Caplette, Romain Marre, Olivier Bertin, Stéphane
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Published in
Communications Biology
Gauvain et al demonstrate that optogenetic therapy using the AAV2.7m8- ChR-tdT construct can partially restore vision in non-human primates to levels above those considered legally-blind. This study enables the identification of the most suitable construct for ongoing clinical trials attempting vision restoration in patients with retinitis pigmento...
Genera, Mariano Quioc-Salomon, Barbara Nourisson, Antonin Colcombet-Cazenave, Baptiste Haouz, Ahmed Mechaly, Ariel Matondo, Mariette Duchateau, Magalie König, Alexander Windisch, Marc P.
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Published in
Scientific Reports
Interactions between the hepatitis B virus core protein (HBc) and host cell proteins are poorly understood, although they may be essential for the propagation of the virus and its pathogenicity. HBc has a C-terminal PDZ (PSD-95, Dlg1, ZO-1)-binding motif (PBM) that is responsible for interactions with host PDZ domain-containing proteins. In this wo...
Bélondrade, Maxime Nicot, Simon Mayran, Charly Bruyere-Ostells, Lilian Almela, Florian Di Bari, Michele A. Levavasseur, Etienne Watts, Joel C. Fournier-Wirth, Chantal Lehmann, Sylvain
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Published in
Scientific Reports
Unlike variant Creutzfeldt–Jakob disease prions, sporadic Creutzfeldt–Jakob disease prions have been shown to be difficult to amplify in vitro by protein misfolding cyclic amplification (PMCA). We assessed PMCA of pathological prion protein (PrPTSE) from 14 human sCJD brain samples in 3 substrates: 2 from transgenic mice expressing human prion prot...
Schröder, Stefan E. Poch, Olivier Ferrari, Marco Angelis, Simone De Sultana, Robin Potin, Sandra M. Beck, Pierre De Sanctis, Maria Cristina Schmitt, Bernard
Published in
Nature Communications
The origin of blue ejecta around the fresh craters of dwarf planet Ceres is unknown. Here, the authors show that the blue color results from high porosity of the surface, induced by sublimation of ice-phyllosilicate mixture produced by impacts.
Pinto, Joseph P. Li, Jiazheng Mills, Franklin P. Marcq, Emmanuel Evdokimova, Daria Belyaev, Denis Yung, Yuk L.
Published in
Nature Communications
Photochemistry of sulfur species in the upper Venus atmosphere is not well understood and the identity of ultraviolet (UV) absorber(s) remain unknown. Here, the authors show that sulfur monoxide dimer chemistry is a possible source of polysulfur, which could be responsible for the UV absorption.