Serino, Silvia Scarpina, Federica Keizer, Anouk Pedroli, Elisa Dakanalis, Antonios Castelnuovo, Gianluca Chirico, Alice Novelli, Margherita Gaudio, Santino Riva, Giuseppe
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Published in
Frontiers in Psychology
Introduction: The available clinical guidelines for super-super obese patients (i.e., with body mass index (BMI) > 60 kg/m2) that are not suitable for bariatric surgery mandate a palliative multidisciplinary treatment (i.e., production and maintenance of weight loss) provided in a center of excellence. However, the modality and the impact of this a...
Prieto-Domínguez, Nestor Ordóñez, Raquel Fernández, Anna García-Palomo, Andres Muntané, Jordi González-Gallego, Javier Mauriz, José L.
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Frontiers in Pharmacology
The multikinase inhibitor sorafenib is, at present, the only drug approved for the treatment of hepatocellular carcinoma (HCC), one of the most lethal types of cancer worldwide. However, the increase in the number of sorafenib tumor resistant cells reduces efficiency. A better knowledge of the intracellular mechanism of the drug leading to reduced ...
Yoshimura, Natsue Nishimoto, Atsushi Belkacem, Abdelkader Nasreddine Shin, Duk Kambara, Hiroyuki Hanakawa, Takashi Koike, Yasuharu
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Frontiers in Neuroscience
With the goal of providing assistive technology for the communication impaired, we proposed electroencephalography (EEG) cortical currents as a new approach for EEG-based brain-computer interface spellers. EEG cortical currents were estimated with a variational Bayesian method that uses functional magnetic resonance imaging (fMRI) data as a hierarc...
Varoni, Elena M. Lo Faro, Alfredo Fabrizio Sharifi-Rad, Javad Iriti, Marcello
Published in
Frontiers in Nutrition
Resveratrol is a pleiotropic phytochemical belonging to the stilbene family. Though it is only significantly present in grape products, a huge amount of preclinical studies investigated its anticancer properties in a plethora of cellular and animal models. Molecular mechanisms of resveratrol involved signaling pathways related to extracellular grow...
Otal, Begonya Dutta, Anirban Foerster, Águida Ripolles, Oscar Kuceyeski, Amy Miranda, Pedro C. Edwards, Dylan J. Ilić, Tihomir V. Nitsche, Michael A. Ruffini, Giulio
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Published in
Frontiers in Neurology
Stroke is a leading cause of serious long-term disability worldwide. Functional outcome depends on stroke location, severity, and early intervention. Conventional rehabilitation strategies have limited effectiveness, and new treatments still fail to keep pace, in part due to a lack of understanding of the different stages in brain recovery and the ...
Boeva, Valentina
Published in
Frontiers in Genetics
Eukaryotic genomes contain a variety of structured patterns: repetitive elements, binding sites of DNA and RNA associated proteins, splice sites, and so on. Often, these structured patterns can be formalized as motifs and described using a proper mathematical model such as position weight matrix and IUPAC consensus. Two key tasks are typically carr...
Benomar, Lahcen Lamhamedi, Mohammed S. Rainville, André Beaulieu, Jean Bousquet, Jean Margolis, Hank A.
Published in
Frontiers in Plant Science
Assisted population migration (APM) is the intentional movement of populations within a species range to sites where future environmental conditions are projected to be more conducive to growth. APM has been proposed as a proactive adaptation strategy to maintain forest productivity and to reduce the vulnerability of forest ecosystems to projected ...
Pacheco, Maria P. Pfau, Thomas Sauter, Thomas
Published in
Frontiers in Physiology
Recent progress in high-throughput data acquisition has shifted the focus from data generation to processing and understanding of how to integrate collected information. Context specific reconstruction based on generic genome scale models like ReconX or HMR has the potential to become a diagnostic and treatment tool tailored to the analysis of spec...
Ohtaka-Maruyama, Chiaki Nakajima, Kazunori Alessandra Pierani Maeda, Nobuaki
Published in
Frontiers in Neuroscience
The mammalian neocortex shows an extremely well-organized structure that underlies higher brain functions such as cognition, language, and memory. The neocortex consists of a six-layered structure, in which excitatory and inhibitory neurons form complex neural circuits in concert with glial cells. As a result of recent technological innovations in ...
Aladjidi, Nathalie Fernandes, Helder Leblanc, Thierry Vareliette, Amélie Rieux-Laucat, Frédéric Bertrand, Yves Chambost, Hervé Pasquet, Marlène Mazingue, Françoise Guitton, Corinne
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Published in
Frontiers in Pediatrics
Evans syndrome (ES) is a rare autoimmune disorder whose long-term outcome is not well known. In France, a collaborative pediatric network set up via the National Rare Disease Plan now provides comprehensive clinical data in children with this disease. Patients aged less than 18 years at the initial presentation of autoimmune cytopenia have been pro...