Published in Heart (British Cardiac Society)
Cardiovascular diseases i are the most common cause of loss of flying licence globally, and cardiac arrhythmia is the main disqualifier in a substantial proportion of aircrew. Aircrew ii often operate within a demanding physiological environment, that potentially includes exposure to sustained acceleration (usually resulting in a positive gravitati...
Published in Heart (British Cardiac Society)
Valvular heart disease (VHD) is highly relevant in the aircrew population as it may limit appropriate augmentation of cardiac output in high-performance flying and predispose to arrhythmia. Aircrew with VHD require careful long-term follow-up to ensure that they can fly if it is safe and appropriate for them to do so. Anything greater than mild ste...
Published in Encyclopedia of Human Nutrition
Hypertensive disorders during pregnancy are one of the main causes of maternal death worldwide, particularly complications of pre-eclampsia and eclampsia. Although etiology remains unknown, deficiencies in specific nutrients have been proposed as contributing to the pathophysiology of the disease, suggesting that nutritional interventions could pre...
Published in Family Medicine and Community Health
Published in Veterinary Record
Published in Circulation. Cardiovascular genetics
Previous reports have implicated multiple genetic loci associated with AF, but the contributions of genome-wide variation to AF susceptibility have not been quantified. We assessed the contribution of genome-wide single-nucleotide polymorphism variation to AF risk (single-nucleotide polymorphism heritability, h2g ) using data from 120 286 unrelated...
Published in Open heart
Prolonged QT interval predisposes to ventricular arrhythmias and sudden cardiac death. However, the association between QT interval and mortality by the level of pre-existing kidney function has not been investigated. We followed 6565 participants from the National Health and Nutrition Examination Survey III for a median of 13.3 years. Sample divid...
Published in BMJ Open
The protocol has been approved by the Health Ministry Screening Committee, Government of India and the Institutional Ethics Committee at the host institution. Confidentiality and privacy of the participants will be maintained. The findings of the study will be shared with all stakeholders of this research including the participants. Knowledge disse...
Published in Journal of Medical Genetics
Background: While mitochondrial DNA (mtDNA) copy number is strictly regulated during differentiation and according to cell type, very little is known regarding the mechanism which accurately controls mtDNA copy number in human. Exon 2 of the human POLG gene, encoding the catalytic subunit of the mitochondrial-specific DNA polymerase gamma, contains...
Published in BMJ
