Kumar, Meghan Bruce Madan, Jason J Auguste, Peter Taegtmeyer, Miriam Otiso, Lilian Ochieng, Christian B Muturi, Nelly Mgamb, Elizabeth Barasa, Edwine
Published in
BMJ global health
Improvements in maternal and infant health outcomes are policy priorities in Kenya. Achieving these outcomes depends on early identification of pregnancy and quality of primary healthcare. Quality improvement interventions have been shown to contribute to increases in identification, referral and follow-up of pregnant women by community health work...
Ji, Niannian Mukherjee, Neelam Reyes, Ryan M Gelfond, Jonathan Javors, Martin Meeks, Joshua J McConkey, David J Shu, Zhen-Ju Ramamurthy, Chethan Dennett, Ryan
...
Published in
Journal for immunotherapy of cancer
Although intravesical BCG is the standard treatment of high-grade non-muscle invasive bladder cancer (NMIBC), response rates remain unsatisfactory. In preclinical models, rapamycin enhances BCG vaccine efficacy against tuberculosis and the killing capacity of γδ T cells, which are critical for BCG's antitumor effects. Here, we monitored immunity, s...
Kim, Seohyun Kim, Seong A Nam, Gi-Hoon Hong, Yeonsun Kim, Gi Beom Choi, Yoonjeong Lee, Seokyoung Cho, Yuri Kwon, Minsu Jeong, Cherlhyun
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Published in
Journal for immunotherapy of cancer
Uveal melanoma (UM) is the most frequent intraocular malignancy and is resistant to immunotherapy. Nearly 50% of patients with UM develop metastatic disease, and the overall survival outcome remains very poor. Therefore, a treatment regimen that simultaneously targets primary UM and prevents metastasis is needed. Here, we suggest an immunotherapeut...
Di Giorgio, Laura Evans, David K Lindelow, Magnus Nguyen, Son Nam Svensson, Jakob Wane, Waly Welander Tärneberg, Anna
Published in
BMJ global health
Assess the quality of healthcare across African countries based on health providers' clinical knowledge, their clinic attendance and drug availability, with a focus on seven conditions accounting for a large share of child and maternal mortality in sub-Saharan Africa: malaria, tuberculosis, diarrhoea, pneumonia, diabetes, neonatal asphyxia and post...
Lule, Swaib A Gupta, Rishi K Krutikov, Maria Jackson, Charlotte Southern, Jo Abubakar, Ibrahim
Published in
BMJ global health
To investigate the relationship between social risk factors and latent tuberculosis infection (LTBI) among individuals who are eligible for LTBI screening in the United Kingdom (UK). This cross-sectional study used data collected in the UK Prognostic Evaluation of Diagnostic Interferon-Gamma Release Assays (IGRAs) Consortium Study which enrolled 91...
Ulrich, Victoria Konaniah, Eddy S Lee, Wan-Ru Khadka, Sadiksha Shen, Yu-Min Herz, Joachim Salmon, Jane E Hui, David Y Shaul, Philip W Mineo, Chieko
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Published in
Journal of the American Heart Association
Antiphospholipid syndrome patients have antiphospholipid antibodies (aPLs) that promote thrombosis, and they have increased cardiovascular disease risk. Although the basis for the thrombosis has been well delineated, it is not known why antiphospholipid syndrome patients also have an increased prevalence of nonthrombotic vascular occlusion. The aim...
King, Carina Bar-Zeev, Naor Phiri, Tambosi Beard, James Mvula, Hazzie Crampin, Amelia Heinsbroek, Ellen Hungerford, Dan Lewycka, Sonia Verani, Jennifer
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Published in
BMJ global health
Pneumococcal conjugate vaccine (PCV) and rotavirus vaccine (RV) are key tools for reducing common causes of infant mortality. However, measurement of population-level mortality impact is lacking from sub-Saharan Africa. We evaluated mortality impact and vaccine effectiveness (VE) of PCV13 introduced in November 2011, with subsequent RV1 roll-out in...
Otto, Catherine M
Published in
Heart
Patient-reported outcome measures (PROMs) now are recognised as an essential element in clinical cardiovascular research studies. In addition, we are increasing aware of significant sex differences, not only in risk factors, clinical presentation and outcomes, but in the treatments provided to patients with cardiovascular disease. In this issue of ...
Aldiss, Susie Fern, Lorna A Phillips, Robert S Callaghan, Amy Dyker, Karen Gravestock, Helen Groszmann, Michael Hamrang, Leila Hough, Rachael McGeachy, Demi
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Published in
BMJ Open
To conduct a UK-wide survey of young people who have experienced cancer, carers and professionals, to identify and prioritise research questions to inform decisions of research funders and support the case for research with this unique cancer population. James Lind Alliance Priority Setting Partnership. UK health service and community. A steering g...
Petkovsek, Daniel S Cherfan, Daniel G Conti, Felipe F Hom, Grant L Ehlers, Justin P Babiuch, Amy S Rachitskaya, Aleksandra V Kaiser, Peter K Schachat, Andrew P Srivastava, Sunil K
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Published in
British Journal of Ophthalmology
The efficacy of mineralocorticoid receptor antagonist eplerenone to treat chronic central serous chorioretinopathy (CSCR) has been established. However, previous studies have been limited by small cohort size and short follow-up duration. This study aims to report 3-year clinical outcomes of patients treated with eplerenone for chronic CSCR. Instit...
