Yuan, Zehu Sunduimijid, Bolormaa Xiang, Ruidong Behrendt, Ralph Knight, Matthew I. Mason, Brett A. Reich, Coralie M. Prowse-Wilkins, Claire Vander Jagt, Christy J. Chamberlain, Amanda J.
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Published in
Genetics Selection Evolution
BackgroundVariants that regulate transcription, such as expression quantitative trait loci (eQTL), have shown enrichment in genome-wide association studies (GWAS) for mammalian complex traits. However, no study has reported eQTL in sheep, although it is an important agricultural species for which many GWAS of complex meat traits have been conducted...
Cornejo, Alberto Caballero, Julio Simirgiotis, Mario Torres, Vanessa Sánchez, Luisa Díaz, Nicolás Guimaraes, Marcela Hernández, Marcos Areche, Carlos Alfaro, Sergio
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Published in
Journal of enzyme inhibition and medicinal chemistry
Parkinson's disease (PD) is a neurodegenerative disorder that affects adult people whose treatment is palliative. Thus, we decided to test three dammarane triterpenes 1, 1a, 1b, and we determined that 1 and 1a inhibit β-aggregation through thioflavine T rather than 1b. Since compound 1 was most active, we determined the interaction between α-synucl...
Tkaczyk, Marcin Gadomska-Prokop, Katarzyna Załuska-Leśniewska, Iga Musiał, Kinga Zawadzki, Jan Jobs, Katarzyna Porowski, Tadeusz Rogowska-Kalisz, Anna Jander, Anna Kirolos, Meritrafat
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Published in
Renal failure
Cystinuria is an inherited disorder that results in increased excretion of cystine in the urine. It accounts for about 1-2% of pediatric kidney stones. In this study, we sought to identify the clinical characteristics of patients with cystinuria in a national cohort. This was a retrospective study involving 30 patients from the Polish Registry of I...
Ahmed, Marwa F Santali, Eman Y El-Haggar, Radwan
Published in
Journal of enzyme inhibition and medicinal chemistry
New piperazine-chalcone hybrids and related pyrazoline derivatives have been designed and synthesised as potential vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors. The National Cancer Institute (NCI) has selected six compounds to evaluate their antiproliferative activity in vitro against 60 human cancer cells lines. Preliminary s...
Pinto, Joseph P. Li, Jiazheng Mills, Franklin P. Marcq, Emmanuel Evdokimova, Daria Belyaev, Denis Yung, Yuk L.
Published in
Nature Communications
Photochemistry of sulfur species in the upper Venus atmosphere is not well understood and the identity of ultraviolet (UV) absorber(s) remain unknown. Here, the authors show that sulfur monoxide dimer chemistry is a possible source of polysulfur, which could be responsible for the UV absorption.
Schröder, Stefan E. Poch, Olivier Ferrari, Marco Angelis, Simone De Sultana, Robin Potin, Sandra M. Beck, Pierre De Sanctis, Maria Cristina Schmitt, Bernard
Published in
Nature Communications
The origin of blue ejecta around the fresh craters of dwarf planet Ceres is unknown. Here, the authors show that the blue color results from high porosity of the surface, induced by sublimation of ice-phyllosilicate mixture produced by impacts.
Huang, Fei Wang, Le Zhang, Qian Wan, Zhengce Hu, Liu Xu, Ranran Cheng, Anying Lv, Yongman Liu, Qingquan
Published in
Renal failure
This study explored whether lipid disorders or an elevated atherogenic index of plasma (AIP, a risk factor for cardiovascular diseases) could predict major kidney function decline. We conducted a retrospective 7-year cohort study of 3712 Chinese adults followed up between 2010 and 2017. Major kidney function decline was defined as a ≥ 30% reduction...
Filipiak, Michał Woyciechowski, Michal Czarnoleski, Marcin
Published in
Scientific Reports
Life histories of species may be shaped by nutritional limitations posed on populations. Yet, populations contain individuals that differ according to sex and life stage, each of which having different nutritional demands and experiencing specific limitations. We studied patterns of resource assimilation, allocation and excretion during the growth ...
Zoppi, Johanna Guillaume, Jean-François Neunlist, Michel Chaffron, Samuel
Published in
BMC Bioinformatics
BackgroundMulti-omics experimental approaches are becoming common practice in biological and medical sciences underlining the need to design new integrative techniques and applications to enable the multi-scale characterization of biological systems. The integrative analysis of heterogeneous datasets generally allows to acquire additional insights ...
Alleon, Julien Bernard, Sylvain Olivier, Nicolas Thomazo, Christophe Marin-Carbonne, Johanna
Published in
Communications Earth & Environment
Information on the initial chemical nature of Archean organic materials can survive in rocks despite a complex geological history, according to spatially resolved chemical analyses of 3.4-billion-year old organic films.
