Gauvain, Gregory Akolkar, Himanshu Chaffiol, Antoine Arcizet, Fabrice Khoei, Mina A. Desrosiers, Mélissa Jaillard, Céline Caplette, Romain Marre, Olivier Bertin, Stéphane
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Published in
Communications Biology
Gauvain et al demonstrate that optogenetic therapy using the AAV2.7m8- ChR-tdT construct can partially restore vision in non-human primates to levels above those considered legally-blind. This study enables the identification of the most suitable construct for ongoing clinical trials attempting vision restoration in patients with retinitis pigmento...
Zhang, Haohan Suzuki-Muresan, Tomo Morizet, Yann Gin, Stéphane Abdelouas, Abdesselam
Published in
npj Materials Degradation
Understanding the durability of nuclear glass in the vapor phase is essential for evaluating the long-term safety of the nuclear glass. This work studies the vapor hydration of borosilicate and iodine-bearing glass at 90 °C and relative humidity at 99%. Hydration kinetics was monitored by analyzing the boron and iodine released during the vapor hyd...
Yuan, Zehu Sunduimijid, Bolormaa Xiang, Ruidong Behrendt, Ralph Knight, Matthew I. Mason, Brett A. Reich, Coralie M. Prowse-Wilkins, Claire Vander Jagt, Christy J. Chamberlain, Amanda J.
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Published in
Genetics Selection Evolution
BackgroundVariants that regulate transcription, such as expression quantitative trait loci (eQTL), have shown enrichment in genome-wide association studies (GWAS) for mammalian complex traits. However, no study has reported eQTL in sheep, although it is an important agricultural species for which many GWAS of complex meat traits have been conducted...
Schuwerk, Lukas Hoeltig, Doris Waldmann, Karl-Heinz Valentin-Weigand, Peter Rohde, Judith
Published in
Veterinary Research
Serotyping is the most common method to characterize field isolates of Actinobacillus (A.) pleuropneumoniae, the etiological agent of porcine pleuropneumonia. Based on serology, many farms seem to be infected and antibodies against a wide variety of serovars are detectable, but, so far it is unknown to what degree respective serovars contribute to ...
Yang, Yaodong Bocs, Stéphanie Fan, Haikuo Armero, Alix Baudouin, Luc Xu, Pengwei Xu, Junyang This, Dominique Hamelin, Chantal Iqbal, Amjad
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Published in
Communications Biology
Yaodong Yang et al. report a chromosome-scale genome assembly of the coconut and transcriptome analysis of coconut leaves. Their analysis reveals important steps along the evolutionary trajectory of palms and identifies genes that may play a key role in tolerance to salt stress.
Trotereau, Angélina Boyer, Claudine Bornard, Isabelle Pécheur, Max Jean Bernard Schouler, Catherine Torres-Barceló, Clara
Published in
Scientific Reports
Bacterial wilt caused by the Ralstonia solanacearum species complex (RSSC) is among the most important plant diseases worldwide, severely affecting a high number of crops and ornamental plants in tropical regions. Only a limited number of phages infecting R. solanacearum have been isolated over the years, despite the importance of this bacterium an...
Abdelghani-Idrissi, Soufiane Dubouis, Nicolas Grimaud, Alexis Stevens, Philippe Toussaint, Gwenaëlle Colin, Annie
Published in
Scientific Reports
In this study, the effect of flow of the electrolyte on an electrolysis cell and a zinc cell is investigated. The gain of energy brought by the flow is discussed and compared to the viscous losses in the cells. We point out that the balance between the gained electrical power and the viscous loss power is positive only if the hydrodynamic resistanc...
Schine, Casey M. S. Alderkamp, Anne-Carlijn van Dijken, Gert Gerringa, Loes J. A. Sergi, Sara Laan, Patrick van Haren, Hans van de Poll, Willem H. Arrigo, Kevin R.
Published in
Nature Communications
Primary productivity in the Southern Ocean plays an important role in the drawdown of atmospheric CO2, but phytoplankton growth is limited by iron. Here the authors show that iron from hydrothermal vents fuels massive phytoplankton blooms in the Southern Ocean that have recurred in the same location for decades.
Cornejo, Alberto Caballero, Julio Simirgiotis, Mario Torres, Vanessa Sánchez, Luisa Díaz, Nicolás Guimaraes, Marcela Hernández, Marcos Areche, Carlos Alfaro, Sergio
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Published in
Journal of enzyme inhibition and medicinal chemistry
Parkinson's disease (PD) is a neurodegenerative disorder that affects adult people whose treatment is palliative. Thus, we decided to test three dammarane triterpenes 1, 1a, 1b, and we determined that 1 and 1a inhibit β-aggregation through thioflavine T rather than 1b. Since compound 1 was most active, we determined the interaction between α-synucl...
Dunn, Ian C. De Koning, Dirk-Jan McCormack, Heather A. Fleming, Robert H. Wilson, Peter W. Andersson, Björn Schmutz, Matthias Benavides, Cristina Dominguez-Gasca, Nazaret Sanchez-Rodriguez, Estefania
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Published in
Genetics Selection Evolution
BackgroundThe physiological adaptations that have evolved for egg laying make hens susceptible to bone fractures and keel bone damage. In modern laying hen breeds, longer periods of egg laying could result in a greater risk of poor bone quality, and selection for increased egg production has frequently been stated to be a cause. However, the existi...
