A falsely elevated blood alcohol concentration (BAC) related to an intravenous administration of phenytoin sodium
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
The surveys on quality indicators for the total testing process in clinical laboratories of Fujian Province in China fro...
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives This study investigates the application of 15 Quality Indicators (QIs) in clinical laboratories in Fujian Province, China, from 2018 to 2023. It identifies the main causes of laboratory errors and explores issues in the application of QIs, providing a reference for establishing provincial state-of-the-art and operational quality specific...
Development and validation of a novel 7α-hydroxy-4-cholesten-3-one (C4) liquid chromatography tandem mass spectrometry m...
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives 7α-Hydroxy-4-cholesten-3-one (C4) is the common intermediary of both primary bile acids. C4 is recommended by the British Society of Gastroenterology for the investigation of bile acid diarrhoea (BAD) in patients with chronic diarrhoea. This project aimed to develop and validate an assay to quantitate C4 in serum and assess the stability...
The role of functional vitamin D deficiency and low vitamin D reservoirs in relation to cardiovascular health and mortal...
...
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives The role of vitamin D deficiency in cardiovascular disease (CVD) is controversial. Inherent biological and analytical limitations compromise the specificity of widely used 25-hydroxyvitamin D [25(OH)D] cut-offs. Simultaneous determination of 25(OH)D and 24,25-dihydroxyvitamin D [24,25(OH)2D] permits a functional assessment of vitamin D m...
Simplified preanalytical laboratory procedures for therapeutic drug monitoring (TDM) in patients treated with high-dose ...
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
EFLM Task Force Preparation of Labs for Emergencies (TF-PLE) survey on cybersecurity
...Published in Clinical Chemistry and Laboratory Medicine (CCLM)
A standard to report biological variation data studies – based on an expert opinion
...Published in Clinical Chemistry and Laboratory Medicine (CCLM)
There is a need for standards for generation and reporting of Biological Variation (BV) reference data. The absence of standards affects the quality and transportability of BV data, compromising important clinical applications. To address this issue, international expert groups under the European Federation of Clinical Chemistry and Laboratory Medi...
Blood self-sampling devices: innovation, interpretation and implementation in total lab automation
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
The introduction of the vacuum tube in 1949 revolutionized blood collection, significantly improving sample quality and patient comfort. Over the past 75 years, laboratory diagnostics have evolved drastically, from manual to automated processes, reducing required test volumes by over 1,000 times. Despite these advancements, venous blood collection ...
Correction of negative-interference from calcium dobesilate in the Roche sarcosine oxidase creatinine assay using CuO
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Detection of serum CC16 by a rapid and ultrasensitive magnetic chemiluminescence immunoassay for lung disease diagnosis
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives It has been reported that serum Clara cell secreted protein 16 (CC16) is a potential biomarker for lung injury diseases, but currently, there is no other method that is faster, more accurate, or more sensitive being applied in clinical practice apart from ELISA. The current study was designed to established a magnetic nanoparticles chemi...
