Multi-fidelity surrogate models combining dimensionality reduction and an intermediate surrogate in the reduced space allow a cost-effective emulation of simulators with functional outputs. The surrogate is an input-output mapping learned from a limited number of simulator evaluations. This computational efficiency makes surrogates commonly used fo...
One of the challenge that face the effectiveness of Polyvinyl Chloride geomembranes (PVC GMs) as a hydraulic barrier is the capacity to withstand unexpected mechanical actions, particularly tensile forces, during installation and throughout their lifespan. These forces pose risks of premature failure and impermeability degradation. In this study, t...
International audience
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives An insulin resistant state is characteristic of patients with type 2 diabetes, polycystic ovary syndrome, and metabolic syndrome. Identification of insulin resistance (IR) is most readily achievable using formulae combining plasma insulin and glucose results. In this study, we have used data from the European Biological Variation Study (...
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Oligoclonal bands (OCB) analysis is the reference standard for detecting an intrathecal IgG synthesis. Alongside OCB, free light chains kappa (FLCκ) are considered an additional sensitive biomarker for determining patterns 2 or 3, indicating intrathecal Ig synthesis. However, kFLC IF is not suitable for detecting a monoclonal pattern 5. ...
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Soluble transferrin receptor (sTfR) is a marker of both erythropoiesis and iron status and is considered useful for detecting iron deficiency, especially in inflammatory conditions, but reference intervals covering the entire pediatric age spectrum are lacking. Methods We studied 1,064 (48.5 % female) healthy children of the entire pedia...
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
The first part of this Inter-Society Document describes the mechanisms involved in the development of cardiovascular diseases, particularly arterial hypertension, in adults and the elderly. It will also examine how consistent physical exercise during adolescence and adulthood can help maintain blood pressure levels and prevent progression to sympto...
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
The healthcare systems are a prime target for cyber-attacks due to the sensitive nature of the information combined with the essential need for continuity of care. Medical laboratories are particularly vulnerable to cyber-attacks for a number of reasons, including the high level of information technology (IT), computerization and digitization. Base...
Published in Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Recently published 2023 ACR/EULAR APS classification criteria emphasize the importance of quantifying single-, double-, and triple-antiphospholipid antibody positivity, distinguishing between IgG and IgM isotypes, and delineating moderate/high levels of anticardiolipin (aCL) and anti-β2 glycoprotein I (anti-β2GPI) antibodies. We aimed to...
