Cornejo, Alberto Caballero, Julio Simirgiotis, Mario Torres, Vanessa Sánchez, Luisa Díaz, Nicolás Guimaraes, Marcela Hernández, Marcos Areche, Carlos Alfaro, Sergio
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Published in
Journal of enzyme inhibition and medicinal chemistry
Parkinson's disease (PD) is a neurodegenerative disorder that affects adult people whose treatment is palliative. Thus, we decided to test three dammarane triterpenes 1, 1a, 1b, and we determined that 1 and 1a inhibit β-aggregation through thioflavine T rather than 1b. Since compound 1 was most active, we determined the interaction between α-synucl...
Rocha, Rebeca Froes Del Sarto, Juliana L Gomes, Giovanni F Gonçalves, Mariana P Rachid, Milene A Smetana, Juliana H C Souza, Daniele G Teixeira, Mauro Martins Marques, Rafael Elias
Published in
Virulence
St. Louis encephalitis virus (SLEV) is a neglected mosquito-borne flavivirus that causes severe neurological disease in humans. SLEV replication in the central nervous system (CNS) induces the local production of interferons (IFNs), which are attributed to host protection. The antiviral response to SLEV infection in the CNS is not completely unders...
Mohring, Bertille Brischoux, François Angelier, Frédéric
Published in
Avian Research
BackgroundLand-use change is one of the main drivers of the global erosion of biodiversity. In that context, it is crucial to understand how landscape characteristics drive the presence of rare endangered species. Nevertheless, it is also important to study common species in multiple habitats, because they represent a large proportion of biodiversi...
Dunn, Ian C. De Koning, Dirk-Jan McCormack, Heather A. Fleming, Robert H. Wilson, Peter W. Andersson, Björn Schmutz, Matthias Benavides, Cristina Dominguez-Gasca, Nazaret Sanchez-Rodriguez, Estefania
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Genetics Selection Evolution
BackgroundThe physiological adaptations that have evolved for egg laying make hens susceptible to bone fractures and keel bone damage. In modern laying hen breeds, longer periods of egg laying could result in a greater risk of poor bone quality, and selection for increased egg production has frequently been stated to be a cause. However, the existi...
Tkaczyk, Marcin Gadomska-Prokop, Katarzyna Załuska-Leśniewska, Iga Musiał, Kinga Zawadzki, Jan Jobs, Katarzyna Porowski, Tadeusz Rogowska-Kalisz, Anna Jander, Anna Kirolos, Meritrafat
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Published in
Renal failure
Cystinuria is an inherited disorder that results in increased excretion of cystine in the urine. It accounts for about 1-2% of pediatric kidney stones. In this study, we sought to identify the clinical characteristics of patients with cystinuria in a national cohort. This was a retrospective study involving 30 patients from the Polish Registry of I...
Ahmed, Marwa F Santali, Eman Y El-Haggar, Radwan
Published in
Journal of enzyme inhibition and medicinal chemistry
New piperazine-chalcone hybrids and related pyrazoline derivatives have been designed and synthesised as potential vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors. The National Cancer Institute (NCI) has selected six compounds to evaluate their antiproliferative activity in vitro against 60 human cancer cells lines. Preliminary s...
Morel-Journel, Thibaut Assié, Sébastien Vergu, Elisabeta Mercier, Jean-Baptiste Bonnet-Beaugrand, Florence Ezanno, Pauline
Published in
Veterinary Research
Bovine respiratory diseases (BRD) are a major concern for the beef cattle industry, as beef calves overwhelmingly develop BRD symptoms during the first weeks after their arrival at fattening units. These cases occur after weaned calves from various cow-calf producers are grouped into batches to be sold to fatteners. Cross-contaminations between cal...
Chen, Yufeng Tian, Di Xu, Lixin Yan, Ruofeng Li, Xiangrui Shah, Muhammad Ali A. Song, Xiaokai
Published in
Veterinary Research
Rhomboid-like proteases (ROMs) are considered as new candidate antigens for developing new-generation vaccines due to their important role involved in the invasion of apicomplexan protozoa. In prior works, we obtained a ROM2 sequence of Eimeria maxima (EmROM2). This study was conducted to evaluate the immunogenicity and protective efficacy of EmROM...
Matas, Emmanuel Maisterrena, Alexandre Thabault, Mathieu Balado, Eric Francheteau, Maureen Balbous, Anais Galvan, Laurie Jaber, Mohamed
Published in
Molecular Autism
BackgroundContrasting findings were reported in several animal models with a Shank3 mutation used to induce various autism spectrum disorder (ASD) symptoms. Here, we aimed at investigating behavioral, cellular, and molecular consequences of a C-terminal (frameshift in exon 21) deletion in Shank3 protein in mice, a mutation that is also found in cli...
Beaumont, Martin Blanc, Fany Cherbuy, Claire Egidy, Giorgia Giuffra, Elisabetta Lacroix-Lamandé, Sonia Wiedemann, Agnès
Published in
Veterinary Research
In livestock species, the monolayer of epithelial cells covering the digestive mucosa plays an essential role for nutrition and gut barrier function. However, research on farm animal intestinal epithelium has been hampered by the lack of appropriate in vitro models. Over the past decade, methods to culture livestock intestinal organoids have been d...
