Winkler, J Ramirez, G A Thal, L J Waite, J J
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nerve growth factor (NGF) enhances cholinergic functioning in animals with a compromised cholinergic basal forebrain (CBF). Immunotoxic lesions targeting low-affinity NGF receptor (p75NGF receptor)-bearing CBF neurons provide a selective model for testing the effects of NGF on residual cholinergic neurons. Rats received PBS or the immunotoxin 192Ig...
Guillou, J L Rose, G M Cooper, D M
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Adenylyl cyclases (ACs) are involved in a variety of advanced CNS functions, including some types of learning and memory. At least nine AC isoforms are expressed in the brain, which are divisible into three broad classes based on the ability of Ca(2+) to modulate their activity. This study examined the hypothesis that different learning tasks would...
Xu, D Bureau, Y McIntyre, D C Nicholson, D W Liston, P Zhu, Y Fong, W G Crocker, S J Korneluk, R G Robertson, G S
...
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Transient forebrain ischemia produced by four-vessel occlusion (4-VO) triggers the delayed death of CA1 neurons in the hippocampus, resulting in behavioral deficits of spatial learning performance. We demonstrate that CA1 neuronal loss induced by 4-VO (12 min) is preceded by a selective and marked elevation of catalytically active caspase-3 in thes...
Holcomb, Leigh A. Gordon, Marcia N. Jantzen, Paul Hsiao, Karen Duff, Karen Morgan, Dave
Published in
Behavior Genetics
Mutations in the amyloid precursor protein (mAPP) and in presenilin 1 (mPS1) have both been linked to increased production of the β-amyloid peptide (Aβ). Doubly transgenic mice produced by mating of a parental line carrying the “Swedish” (K670N/M671L) APP mutation with a FAD4 (M146L) mutant presenilin 1 line developed numerous fibrillar Aβ deposits...
Devan, B D White, N M
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
We investigated the effects of localized medial and lateral CPu lesions and fornix/fimbria lesions on responses to a local cue and to behavior based on cognitive-spatial information in the water maze. Rats were trained concurrently on the cue (visible platform) and spatial (submerged platform) components of the task, followed by a test in which res...
Moser, M B Moser, E I
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
To determine whether memory is processed in a localized or distributed manner by the hippocampus, we inactivated small regions of the structure in pretrained rats before a retention test. Ibotenic acid-induced lesions removing 40% of the hippocampal tissue disrupted retrieval of spatial memory in a water maze but failed to affect new learning or re...
Okabe, S Collin, C Auerbach, J M Meiri, N Bengzon, J Kennedy, M B Segal, M McKay, R D
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The effects of changing NMDA receptor subunit composition on synaptic plasticity in the hippocampus were analyzed by creating transgenic mice overexpressing NR2D, a predominantly embryonic NMDA receptor subunit. NMDA-evoked currents in the transgenic mice had smaller amplitudes and slower kinetics. The transgenics also displayed age-dependent defic...
Frick, K M Price, D L Koliatsos, V E Markowska, A L
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nerve growth factor (NGF) infusion significantly reduces spatial recent memory deficits in aged rats, an effect that has great relevance to the treatment of memory impairments characteristic of patients with Alzheimer's disease. The present study was designed to examine whether this NGF-induced improvement in spatial recent memory persists after th...
Markowska, A L Price, D Koliatsos, V E
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nerve growth factor (NGF) ameliorates age-related deficits in certain types of memory in rats. Although the effects of NGF on reference memory are well documented, the influence of NGF on recent memory is less well understood. The issue of recent memory is of primary importance in the design of therapies for cognitive disorders, because this type o...
