Schuhmacher, S Schulz, E Oelze, M König, A Roegler, C Lange, K Sydow, L Kawamoto, T Wenzel, P Münzel, T
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Published in
British journal of pharmacology
The chronic use of organic nitrates is limited by serious side effects including oxidative stress, nitrate tolerance and/or endothelial dysfunction. The side effects and potency of nitroglycerine depend on mitochondrial aldehyde dehydrogenase (ALDH-2). We sought to determine whether this concept can be extended to a new class of organic nitrates wi...
Al-Solaiman, Yaser Jesri, Ammar Zhao, Yumin Morrow, Jason D. Egan, Brent M.
Published in
Journal of human hypertension
Salt induces oxidative stress in salt-sensitive (SS) animals and man. It is unknown in SS subjects if the low-sodium Dietary Approaches to Stop Hypertension (LS-DASH) reduces oxidative stress more than DASH, which is high in anti-oxidants. To assess the effects of DASH and LS-DASH on oxidative stress, 19 volunteers were studied after 3-weeks of a s...
Radovits, T Bömicke, T Kökény, G Arif, R Loganathan, S Kécsán, K Korkmaz, S Barnucz, E Sandner, P Karck, M
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Published in
British journal of pharmacology
Our results demonstrate that impaired vascular cGMP signalling contributes to the development of diabetic vascular and cardiac dysfunction, which can be prevented by chronic phosphodiesterase-5 inhibition.
Nuyt, Anne Monique Alexander, Barbara T
Published in
Current opinion in nephrology and hypertension
While the complexity of the interactions between antenatal and postnatal influences on adult blood pressure is increasingly recognized, the importance of postnatal life in (positively) modulating developmental programming offers the hope of a critical window of opportunity to reverse programming and prevent or reduce related adult-onset diseases.
Hadoke, Patrick W F Webb, David Kirkby, Nicholas S
Neointimal hyperplasia, the proliferative growth of the innermost layer of the blood vessel wall, is a key process in the response to vascular injury, underlying conditions such as post-interventional restenosis and vein/arterial graft disease. One of the many mediators implicated in this process is endothelin-1 (ET-1), a potent vasoconstrictor wit...
Hadoke, Patrick W F Webb, David Kirkby, Nicholas S
United Kingdom
Brown, Emile N Burris, Nicholas S Kon, Zachary N Grant, Michael C Brazio, Philip S Xu, Chenyang Laird, Patrick Gu, Junyen Kallam, Seeta Desai, Pranjal
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Published in
Atherosclerosis
Background The radial artery’s (RA) tendency to spasm when used as a bypass graft may relate to features of the RA itself. We imaged RA conduits before and after CABG in order to characterize intimal abnormalities that might relate to the risk of spasm. Methods RA conduits from thirty-two CABG patients were imaged intraoperatively using catheter-ba...
Han, Byung Hee Zhou, Meng-Liang Abousaleh, Fadi Brendza, Robert P Dietrich, Hans H Koenigsknecht-Talboo, Jessica Cirrito, John R Milner, Eric Holtzman, David M Zipfel, Gregory J
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The contributing effect of cerebrovascular pathology in Alzheimer's disease (AD) has become increasingly appreciated. Recent evidence suggests that amyloid-beta peptide (Abeta), the same peptide found in neuritic plaques of AD, may play a role via its vasoactive properties. Several studies have examined young Tg2576 mice expressing mutant amyloid p...
Nishiyama, Steven K Wray, D Walter Richardson, Russell S
Published in
American journal of physiology. Heart and circulatory physiology
With little known regarding sex and limb heterogeneity, we investigated vascular reactivity and ischemic reperfusion (IR) in the upper and lower extremities of 15 healthy men (26 +/- 2 yr) and women (23 +/- 1 yr). Doppler ultrasound was used to evaluate IR and flow-mediated dilation (FMD) after suprasystolic cuff occlusion in both the arm [brachial...
Dayal, Sanjana Rodionov, Roman N Arning, Erland Bottiglieri, Teodoro Kimoto, Masumi Murry, Daryl J Cooke, John P Faraci, Frank M Lentz, Steven R
Published in
American journal of physiology. Heart and circulatory physiology
Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthase, has been proposed to be a mediator of vascular dysfunction during hyperhomocysteinemia. Levels of ADMA are regulated by dimethylarginine dimethylaminohydrolase (DDAH). Using both in vitro and in vivo approaches, we tested the hypothesis that hyperhomocysteine...
