Favreau, Frederic Rossard, Ludivine Zhang, Keqiang Desurmont, Thibault Manguy, Emilie Belliard, Aude Fabre, Stéphane Liu, Jun Han, Zeqiu Thuillier, Raphael
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Published in
American journal of physiology. Renal physiology
Translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor, is an 18-kDa drug- and cholesterol-binding protein localized to the outer mitochondrial membrane and implicated in a variety of cell and mitochondrial functions. To determine the role of TSPO in ischemia-reperfusion injury (IRI), we used both in vivo and in ...
Wang, Haofan Pullambhatla, Mrudula Guilarte, Tomas R. Mease, Ronnie C. Pomper, Martin G.
Published in
Biochemical and Biophysical Research Communications
[ 125I]IodoDPA-713 [ 125I] 1, which targets the translocator protein (TSPO, 18 kDa), was synthesized in seven steps from methyl-4-methoxybenzoate as a tool for quantification of inflammation in preclinical models. Preliminary in vitro autoradiography and in vivo small animal imaging were performed using [ 125I] 1 in a neurotoxicant-treated rat and ...
Rone, Malena B. Fan, Jinjiang Papadopoulos, Vassilios
Published in
Biochimica et biophysica acta
The transfer of cholesterol from the outer to the inner mitochondrial membrane is the rate-limiting step in hormone-induced steroid formation. To ensure that this step is achieved efficiently, free cholesterol must accumulate in excess at the outer mitochondrial membrane and then be transferred to the inner membrane. This is accomplished through a ...
Hirshler, Yafit (Kuttner) Polat, Uri Biegon, Anat
Published in
Experimental neurology
Deep brain stimulation (DBS) is an established treatment for advanced Parkinson’s disease (PD). The procedure entails intracranial implantation of an electrode in a specific brain structure followed by chronic stimulation. Although the beneficial effects of DBS on motor symptoms in PD are well known, it is often accompanied by cognitive impairments...
Chen, Bing-bing Zirkin, B.R. Ge, Ren-Shan
Published in
Comprehensive Toxicology
Leydig cells are the testicular cells responsible for the biosynthesis and secretion of androgens, which are critical for the development of the reproductive tract and for reproductive function in the male. There are two distinct populations of Leydig cells: fetal Leydig cells (FLCs), which originate and function in the fetus but largely regress so...
de Lima, Camila Bento Tamura, Eduardo K. Montero-Melendez, Trindad Palermo-Neto, João Perretti, Mauro Markus, Regina P. Farsky, Sandra Helena Poliselli
Published in
Biochemical and Biophysical Research Communications
The 18 kDa translocator protein (TSPO) also known as the peripheral benzodiazepine receptor (PBR), mediates the transportation of cholesterol and anions from the outer to the inner mitochondrial membrane in different cells types. Although recent evidences indicate a potential role for TSPO in the development of inflammatory processes, the mechanism...
Owen, David R.J. Matthews, Paul M.
Published in
International Review of Neurobiology
Microglia are rapidly activated by a wide range of neuropathological insults. Quantifying microglial density in vivo would allow a new, potentially important range of clinic-pathological correlations. Microglia express the 18 kDa translocator protein (TSPO) which can be quantified by the positron emission tomography (PET) ligand [ 11C]PK11195, alth...
Jučaite, Aurelija Cselényi, Zsolt Arvidsson, Annie Åhlberg, Gabrielle Julin, Per Varnäs, Katarina Stenkrona, Per Andersson, Jan Halldin, Christer Farde, Lars
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Published in
EJNMMI Research
BackgroundPositron-emission tomography and the radioligand [11C](R)-PK11195 have been used for the imaging of the translocator protein (TSPO) and applied to map microglia cells in the brain in neuropsychiatric disorders. [11C](R)-PK11195 binding has been quantified using reference region approaches, with the reference defined anatomically or using ...
Thuillier, R. Hauet, T.
Translocator protein (TSPO), formerly known as peripheral-type benzodiazepine receptor (PBR), has been described in several tissues and characterized as one of the main elements of steroidogenesis. However, TSPO is also involved in other pathways and cell functions, such as apoptosis regulation, protein import, membrane biogenesis, cell cycle regul...
Leaver, Katherine R Reynolds, Aaron Bodard, Sylvie Guilloteau, Denis Chalon, Sylvie Kassiou, Michael
Published in
ACS chemical neuroscience
There is evidence that excitotoxicity and prolonged microglial activation are involved in neuronal death in neurodegenerative disorders. Activated microglia express various molecules, including the translocator protein 18 kDa (TSPO; formerly known as the peripheral benzodiazepine receptor) on the outer mitochondrial membrane. The TSPO is a novel ta...
