Airas, Laura Rissanen, Eero Rinne, Juha
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Multiple sclerosis (MS) is a complex disease, where several processes can be selected as a target for positron emission topography (PET) imaging. Unlike magnetic resonance imaging (MRI), PET provides specific and quantitative information, and unlike neuropathology, it can be non-invasively applied to living patients, which enables longitudinal foll...
Wang, Yuchuan Coughlin, Jennifer M Ma, Shuangchao Endres, Christopher J Kassiou, Michael Sawa, Akira Dannals, Robert F Petri, Michelle Pomper, Martin G
Published in
Lupus
Objective Inflammation secondary to autoantibody-mediated effects occurring in multiple organs is a hallmark of systemic lupus erythematosus (SLE). The inflammatory response to SLE-mediated damage in brain parenchyma has been postulated in both normal and cognitively impaired individuals. Our goal is to use molecular imaging to investigate the dist...
De Picker, Livia J Morrens, Manuel Chance, Steven A Boche, Delphine
Published in
Frontiers in psychiatry
Schizophrenia poses a tremendous health, social, and economic burden upon patients and society, indicating current treatment options remain inadequate. Recent findings from several lines of evidence have pointed to the importance of immune system involvement in not only premorbid neurodevelopmental but also subsequent symptom generation and aging p...
Daniele, Simona Barresi, Elisabetta Zappelli, Elisa Marinelli, Luciana Novellino, Ettore Da Settimo, Federico Taliani, Sabrina Trincavelli, Maria L Martini, Claudia
Published in
Oncotarget
The development of multi-target drugs and irreversible modulators of deregulated signalling proteins is the major challenge for improving glioblastoma multiforme (GBM) treatment. Reversible single-target drugs are not sufficient to sustain a therapeutic effect over time and may favour the activation of alternative signalling pathways and the onset ...
Fan, Jinjiang Campioli, Enrico Midzak, Andrew Culty, Martine Papadopoulos, Vassilios
Published in
Proceedings of the National Academy of Sciences of the United States of America
Translocator protein (TSPO) is a key member of the mitochondrial cholesterol transport complex in steroidogenic tissues. To assess the function of TSPO, we generated two lines of Cre-mediated Tspo conditional knockout (cKO) mice. First, gonadal somatic cell-targeting Amhr2-Cre mice were crossed with Tspo-floxed mice to obtain F1 Tspo Amhr2 cKO mice...
Su, Zhangjie Roncaroli, Federico Durrenberger, Pascal F Coope, David J Karabatsou, Konstantina Hinz, Rainer Thompson, Gerard Turkheimer, Federico E Janczar, Karolina Du Plessis, Daniel
...
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
PET with (11)C-(R)PK11195 in human gliomas predominantly reflects TSPO expression in tumor cells. It therefore has the potential to effectively stratify patients who are suitable for TSPO-targeted treatment.
DE Rosa, Aniello Zappavigna, Silvia Villa, Maria Rosaria Improta, Salvatore Cesario, Elena Mastrullo, Lucia Caraglia, Michele Stiuso, Paola
Published in
Oncology letters
Principally located in the outer mitochondrial membrane, the translocator protein (TSPO) is an 18-kDa transmembrane protein that is a key component of the mitochondrial permeability transition pore. TSPO is associated with a number of biological processes, including apoptosis, the regulation of cellular proliferation, porphyrin transport and heme b...
Introduction: The 18-kDa mitochondrial translocator protein (TSPO) is up-regulated in high grade astrocytomas and can be imaged by positron emission tomography (PET) using the selective radiotracer [11C]-(R)PK11195. We investigated [11C]-(R)PK11195 binding in human gliomas and its relationship with TSPO expression in tumor tissue and glioma associa...
Povarnina, P Yu Yarkov, S A Gudasheva, T A Yarkova, M A Seredenin, S B
Published in
Acta naturae
The translocator protein (TSPO) promotes the translocation of cholesterol to the inner mitochondrial membrane and mediates steroid formation. In this study, we first report on a biological evaluation of the dipeptide GD-23 (N-carbobenzoxy-L tryptophanyl-L isoleucine amide), a structural analogue of Alpidem, the principal TSPO ligand. We show that G...
Leneveu-Jenvrin, Charlène Connil, Nathalie Bouffartigues, Emeline Papadopoulos, Vassilios Feuilloley, Marc G J Chevalier, Sylvie
Published in
Frontiers in microbiology
The translocator protein (TSPO), which was previously designated as the peripheral-type benzodiazepine receptor, is a 3.5 billion year-old evolutionarily conserved protein expressed by most Eukarya, Archae and Bacteria, but its organization and functions differ remarkably. By taking advantage of the genomic data available on TSPO, we focused on bac...
