Dialogues in clinical neuroscience
The development of safe and effective new drug treatments for schizophrenia poses a challenging task. This class of drugs is known to be associated with a wide range of serious and troublesome safety problems that include neurological, cardiac, endocrine, and metabolic side effects. Many of these drugs have a narrow therapeutic index and generate m...
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation
Gender-related differences in I(Ca,L), I(to), and I(Kr )may explain the gender disparities in human cardiac electrophysiology. Female cells have an increased susceptibility to early afterdepolarisations following mild reductions in net repolarising forces. Combined with their greater electrical heterogeneity, this renders them more vulnerable to Td...
Many marketed drugs can cause drug-induced (iatrogenic) QT interval prolongation on the electrocardiogram. An increased QT interval can be associated with a particular ventricular arrhythmia, torsade de pointes, leading to possible sudden cardiac death. We describe the role of cardiac ion channels in this process with particular emphasis on the rap...
The Canadian journal of hospital pharmacy
A substantial proportion (26%) of patients for whom QTc-prolonging medications were prescribed had pre-existing prolongation of the QTc interval. Clinical pharmacists may have a role in reducing the risk of subsequent complications.
Journal of pharmacology & pharmacotherapeutics
The results indicated that proarrhythmic potential of chloroquine and clofilium was well evaluated in both the models; moreover, both the models can be used to assess the proarrhythmic potential of the new drug candidates.
Therapeutic advances in psychopharmacology
We reviewed the literature and found 31 adult cases and 1 newborn case of methadone-associated QTc interval prolongation and/or torsade de pointes (TdP). Parametric statistics may not be useful in studying this issue because methadone-associated TdP is a very rare event and, hence, "an extreme outlier" consistent with scalable randomness. We may ha...
Journal of cardiothoracic and vascular anesthesia