Oyama, Munenori Okada, Kensuke Masuda, Masayuki Shimizu, Yuko Yokoyama, Kazumasa Uzawa, Akiyuki Kawaguchi, Naoki Ikeguchi, Ryotaro Hoshino, Yasunobu Hatano, Taku
...
Published in
Therapeutic Advances in Neurological Disorders
Background: Eculizumab is a humanized monoclonal antibody that targets complement protein C5 and inhibits terminal complement-mediated damage at the neuromuscular junction. Recently, the REGAIN study showed that eculizumab was effective and well tolerated in patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthen...
Shen, Wang Cao, Yang Wang, Xinyun Zhang, Peng Zhou, Qinghua
Published in
Thoracic Cancer
Here, we present a case of invasive thymoma with intraluminal growth into the left and right brachiocephalic veins, superior vena cava and the right atrium. Resection of the mass, double partial upper lobe lobectomy and superior vena cava, and left and right brachiocephalic vein replacement were performed. Pathological diagnosis indicated a mixed h...
Tripathy, Sarthak Arun Raj, Sreedharan Thankarajan Subudhi, Kishan Kaushik, Prateek Kumar, Rakesh
Published in
Indian Journal of Nuclear Medicine : IJNM : The Official Journal of the Society of Nuclear Medicine, India
Thymomas are rare anterior mediastinal tumors that originate in the epithelial cells of the thymus and have a rare propensity to metastasize to extrathoracic locations unless it is a histologic high-grade neoplasm (type B and above). We describe a case of 50-year-old woman diagnosed with type AB thymoma and the role of 18F-fluorodeoxyglucose positr...
Vodicka, Prokop Krskova, Lenka Odintsov, Igor Krizova, Ludmila Sedlackova, Eva Schutzner, Jan Zamecnik, Josef
Published in
Oncology letters
The molecular pathogenesis of thymoma remains largely unknown. It has been recently demonstrated, that activation of Wnt signaling pathway leads to increased incidence of thymoma in murine models. The present study investigated the activation of molecules of the Wnt signaling pathway in human thymoma. A total of 112 thymoma cases with complete clin...
Miura, Kentaro Hamanaka, Kazutoshi Uehara, Tsuyoshi Momose, Masanobu Kanai, Yukiko Matsuoka, Shunichiro Takeda, Tetsu Agatsuma, Hiroyuki Hyogotani, Akira Ito, Ken-ichi
...
Published in
Journal of Thoracic Disease
Background Bone morphogenetic protein-7 (BMP-7) is a transforming growth factor-β superfamily member. We examined whether BMP-7 expression in thymic epithelial tumors is associated with their clinicopathological features. Methods One hundred and thirty-two clinical specimens were analyzed in this study. The expression of BMP-7 was detected using im...
Aoki, Sho Nagashima, Kazuaki Furuta, Minori Makioka, Kouki Fujita, Yukio Saito, Kazuma Kashima, Tomoyuki Nakajima, Nozomi Ikota, Hayato Higuchi, Osamu
...
Published in
Internal Medicine
We herein report the case of a 65-year-old woman diagnosed with myasthenia gravis (MG) after complaining of double vision. The patient had anti-low-density lipoprotein receptor-related protein 4 (LRP4) antibody in her serum, although antibodies against the acetylcholine receptor and muscle-specific tyrosine kinase were not detected. Chest computed ...
Di Nunno, Nunzio Patanè, Federico Giuseppe Amico, Francesco Asmundo, Alessio Pomara, Cristoforo
Published in
Frontiers in Pediatrics
Thymomas are extremely rare in the first 20 years of life, with different clinical presentations: from asymptomatic mediastinal masses to compressive and paraneoplastic syndromes. In pediatric population, the respiratory disorders have a higher incidence. The overall thymoma mortality rate is described as 40% and metastasized tumors are more aggres...
Choe, Giye Ghanie, Amanda Riely, Gregory Rimner, Andreas Park, Bernard J Bains, Manjit S Rusch, Valerie W Adusumilli, Prasad S Downey, Robert J Jones, David R
...
Published in
The Journal of thoracic and cardiovascular surgery
Treatment of patients with thymic malignancies metastatic to the pleura or pericardium is challenging, and benefits of aggressive treatment are unclear. We sought to characterize the long-term outcomes in this population. We retrospectively identified patients who underwent resection for de novo thymic malignancies metastatic to the pleura between ...
Asaf, Belal Bin Puri, Harsh Vardhan Bishnoi, Sukhram Nanda, Navdeep Singh Pulle, Mohan Venkatesh Kumar, Arvind
Published in
Journal of minimal access surgery
Minimally invasive thymectomy is fast becoming the preferred approach for myasthenia gravis and non-invasive thymoma. The most commonly employed approach for minimally invasive thymectomy is the lateral thoracic approach. Safe achievement of radical resection requires adequate visualisation of both the phrenic nerves along their entire course. In o...
Reeve, Elizabeth J Mapletoft, Emma K Schiborra, Frederike Maddox, Thomas W Lamb, Christopher R Warren-Smith, Chris M R
Published in
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
In order to identify CT signs that could be used to distinguish cranial mediastinal lymphoma and thymic epithelial neoplasia, a retrospective case-control study was done. Associations between CT signs and diagnosis were tested using binary logistic regression and results expressed as odds ratio and 95% confidence interval. Sixty-two dogs that had t...
