Garabet, Lamya Ghanima, Waleed Monceyron Jonassen, Christine Skov, Vibe Holst, René Mowinckel, Marie-Christine C Hasselbalch, Hans A Kruse, Torben Thomassen, Mads Liebman, Howard
...
Published in
Platelets
Thrombopoietin-receptor-agonists (TPO-RA) are effective treatments of immune thrombocytopenia (ITP). Previous long-term TPO-RA clinical trials have shown that thrombotic events occurred in 6% of TPO-RA-treated ITP patients. To explore the increased risk of thrombosis, the effects of TPO-RA on markers of coagulation and P-selectin were studied. The ...
Spectre, Galia Mobarrez, Fariborz Stålesen, Ragnhild Östenson, Claes-Göran Varon, David Wallen, Håkan Hjemdahl, Paul
Published in
Platelets
Diabetes mellitus (DM) is associated with prothrombotic alterations, and postprandial hyperglycemia is an independent risk factor for cardiovascular complications. We therefore investigated whether a standardized mixed meal alters circulating microparticles (MPs) and their procoagulant activity in DM patients. Patients with DM type 1 (T1DM, n = 11)...
Marks, Denese C Johnson, Lacey
Published in
Platelets
Platelet concentrates for transfusion have a limited shelf-life, and cryopreservation offers a means of extending platelet shelf-life for at least 2 years. Cryopreservation, however, has some disadvantages, as platelets can be damaged during the freezing and thawing process. Consequently the phenotype of cryopreserved platelets is very different to...
Królczyk, Grzegorz Ząbczyk, Michał Czyżewicz, Grzegorz Plens, Krzysztof Prior, Shannon Butenas, Saulius Undas, Anetta
Published in
Journal of thoracic disease
Faster formation of dense and poorly lyzable fibrin networks have been reported in patients at risk of thromboembolism, including cancer patients. We sought to investigate whether chemotherapy affects plasma fibrin clot properties and their determinants in lung cancer patients. In this observational study we enrolled 83 consecutive patients with ad...
Chelle, P Montmartin, A Piot, M Ardillon, L Wibaut, B Frotscher, B Cournil, M Morin, C Tardy-Poncet, B
Published in
Haemophilia : the official journal of the World Federation of Hemophilia
The thrombin generation (TG) assay can assess individual clotting potential. The thrombin generation potential is correlated with the patient's bleeding phenotype and varies from one patient to the other for the same degree of factor VIII or IX deficiency. To define in vitro for individual haemophilic patients the target factor VIII or IX level req...
Brummel-Ziedins, Kathleen E Gissel, Matthew Neuhaus, Jacqueline Borges, Álvaro H Chadwick, David R Emery, Sean Neaton, James D Tracy, Russell P Baker, Jason V
Published in
Research and practice in thrombosis and haemostasis
Effective HIV treatment with antiretroviral therapy has prolonged survival and shifted causes of death to non-AIDS illnesses such as cardiovascular disease. We have shown that inflammation and HIV viral load associate with pro- and anticoagulant factor imbalances resulting in increased thrombin generation when mathematically modeled. We explore the...
Zwaveling, Suzanne Bloemen, Saartje de Laat, Bas ten Cate, Hugo ten Cate-Hoek, Arina
Published in
TH Open: Companion Journal to Thrombosis and Haemostasis
Background Bleeding is a feared adverse event during anticoagulant treatment. In patients on vitamin K antagonists, most bleedings occur with the international normalized ratio (INR) in the therapeutic range. Currently, identification of high-risk patients via laboratory methods is not reliable. In this systematic review, we assessed the ability of...
Pitkänen, H H Kärki, M Niinikoski, H Tanner, L Näntö-Salonen, K Pikta, M Kopatz, W F Zuurveld, M Meijers, J C M Brinkman, H J M
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Published in
Haemophilia : the official journal of the World Federation of Hemophilia
Lysinuric protein intolerance (LPI), a rare autosomal recessive transport disorder of cationic amino acids lysine, arginine and ornithine, affects intestines, lungs, liver and kidneys. LPI patients may display potentially life-threatening bleeding events, which are poorly understood. To characterize alterations in haemostatic and fibrinolytic varia...
Nilsson, Caroline U Strandberg, Karin Reinstrup, Peter
Published in
Scandinavian journal of clinical and laboratory investigation
The anticoagulant warfarin is commonly monitored with prothrombin time (PT). Viscoelastic haemostatic assays (VHA) are primarily used in situations of acute bleeding to guide haemostatic therapy. Much research has focused on VHA monitoring of new oral anticoagulants. However, many patients are still anticoagulated with warfarin and effect of warfar...
Dargaud, Y Negrier, C Rusen, L Windyga, J Georgiev, P Bichler, J Solomon, C Knaub, S Lissitchkov, T Klamroth, R
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Published in
Haemophilia : the official journal of the World Federation of Hemophilia
For individuals with haemophilia A, prophylaxis with factor VIII (FVIII) is typically directed towards trough activity >1 IU/dL; however, some patients still experience spontaneous bleeding events (sBEs). Aims were to evaluate relationships of endogenous thrombin potential (ETP) and FVIII:C with occurrence of clinical bleeding. GENA-21 was a prospe...
