Adishesh, Meera Alnafakh, Rafah Baird, Duncan M Jones, Rhiannon E Simon, Shannon Button, Lucy Kamal, Areege M Kirwan, John DeCruze, S Bridget Drury, Josephine
...
Published in
International journal of molecular sciences
Telomeres are transcribed as long non-coding RNAs called TERRAs (Telomeric repeat containing RNA) that participate in a variety of cellular regulatory functions. High telomerase activity (TA) is associated with endometrial cancer (EC). This study aimed to examine the levels of three TERRAs, transcribed at chromosomes 1q-2q-4q-10q-13q-22q, 16p and 2...
Benassi, Alessandra Doria, Filippo Pirota, Valentina
Published in
International journal of molecular sciences
Nowadays, an increasing number of heterocyclic-based drugs found application in medicinal chemistry and, in particular, as anticancer agents. In this context, oxadiazoles-five-membered aromatic rings-emerged for their interesting biological properties. Modification of oxadiazole scaffolds represents a valid strategy to increase their anticancer act...
Li, Chun Deng, Xiaobo Zhou, Xiaohu
Published in
Polymers
Organohydrogels with distinct antifreezing and antidehydration properties have aroused great interest among researchers, and various organohydrogels and organohydrogel-based applications have emerged recently. There are two popular synthesis strategies to prepare these antifreezing and antidehydration organohydrogels: the in-situ gelling and the so...
Kumrić, Marko Kurir, Tina Tičinović Borovac, Josip A Božić, Joško
Published in
Biomolecules
With poor outcomes and an immense financial burden, acute coronary syndrome (ACS) and its ischemic repercussions still present a major global health problem. Unfavorable outcomes seem to be mainly due to adverse cardiac remodeling. Since the inflammatory response takes an important role in remodeling secondary to myocardial infarction (MI), and as ...
Sanyal, Sulagna Mondal, Payel Sen, Sabyasachi Sengupta Bandyopadhyay, Sumita Das, Chandrima
Published in
The Biochemical journal
hTERT, the catalytic component of the human telomerase enzyme, is regulated by post-translational modifications, like phosphorylation and ubiquitination by multiple proteins which remarkably affects the overall activity of the enzyme. Here we report that hTERT gets SUMOylated by SUMO1 and polycomb protein CBX4 acts as the SUMO E3 ligase of hTERT. h...
Caprio, Cinzia Sacco, Antonio Giustini, Viviana Roccaro, Aldo M
Published in
Cancers
Multiple myeloma (MM) is a plasma cell dyscrasia characterized by proliferation of clonal plasma cells within the bone marrow. Several advances in defining key processes responsible for MM pathogenesis and disease progression have been made; and dysregulation of epigenetics, including DNA methylation and histone modification, has emerged as a cruci...
Dhalla, Paramvijay Singh Kaul, Arunima Garcia, Jian Bapatla, Anusha Khalid, Raheela Armenta-Quiroga, Ana S Khan, Safeera
Published in
Cureus
Aging is defined as progressive physiological alterations in an organism that lead to senescence. In response to stress, when proliferative-competent cells undergo permanent, irreversible growth arrest (like replicative dividing limit, oncogene activation, oxidative stress, or deoxyribonucleic acid (DNA) damage), it is termed as cellular senescence...
McKelvey, Brittany A Gilpatrick, Timothy Wang, Yongchun Timp, Winston Umbricht, Christopher B Zeiger, Martha A
Published in
Thyroid : official journal of the American Thyroid Association
Background: Telomerase reverse transcriptase (TERT) promoter mutations play a role in carcinogenesis and are found in both tumors and cancer cell lines. TERT promoter methylation, transcription factor binding, chromatin remodeling, and alternative splicing are also known to play an integral role in TERT regulation. Methods: Using nanopore Cas9 targ...
Vieri, Margherita Kirschner, Martin Tometten, Mareike Abels, Anne Rolles, Benjamin Isfort, Susanne Panse, Jens Brümmendorf, Tim H. Beier, Fabian
Published in
International Journal of Molecular Sciences
Dyskeratosis congenita (DKC) is a rare inherited disease of impaired telomere maintenance that progressively leads to multi-organ failure, including the bone marrow. By enhancing telomerase activity, androgen derivatives (ADs) are a potential therapeutic option able to re-elongate previously shortened telomeres. Danazol, oxymetholone, and nandrolon...
Lundberg, Martin Millischer, Vincent Backlund, Lena Martinsson, Lina Stenvinkel, Peter Sellgren, Carl M. Lavebratt, Catharina Schalling, Martin
Published in
Frontiers in Psychiatry
Bipolar disorder is a severe psychiatric disorder which affects more than 1% of the world’s population and is a leading cause of disability among young people. For the past 50 years, lithium has been the drug of choice for maintenance treatment of bipolar disorder due to its potent ability to prevent both manic and depressive episodes as well as su...