Systems Biology and Synthetic Biology in Relation to Drought Tolerance or Avoidance in Plants
Published in Frontiers in Plant Science
Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects.
...
Genetic variants are the primary driver of congenital heart disease (CHD) pathogenesis. However, our ability to identify causative variants is limited. To identify causal CHD genes that are associated with specific molecular functions, the study used prior knowledge to filter de novo variants from 2,881 probands with sporadic severe CHD. This appro...
Multiscale Modeling of Rhythm, Pattern and Information Generation: from Genome to Physiome
Published in Frontiers in Physiology
Modeling Basins of Attraction for Breast Cancer Using Hopfield Networks
Published in Frontiers in Genetics
Cancer is a genetic disease for which traditional treatments cause harmful side effects. After two decades of genomics technological breakthroughs, personalized medicine is being used to improve treatment outcomes and mitigate side effects. In mathematical modeling, it has been proposed that cancer matches an attractor in Waddington's epigenetic la...
Systems Biology Integration and Screening of Reliable Prognostic Markers to Create Synergies in the Control of Lung Canc...
Published in Frontiers in Molecular Biosciences
This picture depicts the whole methodology’s pipeline used for the current work that involves genomics and systems biology to scan for potential lung cancer biomarkers.
Redox Systems Biology: Harnessing the Sentinels of the Cysteine Redoxome.
Published in Antioxidants & redox signaling
Significance: Cellular redox processes are highly interconnected, yet not in equilibrium, and governed by a wide range of biochemical parameters. Technological advances continue refining how specific redox processes are regulated, but broad understanding of the dynamic interconnectivity between cellular redox modules remains limited. Systems biolog...
Mouse Systems Genetics as a Prelude to Precision Medicine.
Published in Trends in genetics : TIG
Mouse models have been instrumental in understanding human disease biology and proposing possible new treatments. The precise control of the environment and genetic composition of mice allows more rigorous observations, but limits the generalizability and translatability of the results into human applications. In the era of precision medicine, stra...
A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease
...Published in Frontiers in Immunology
Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and represents one of the earliest pathomechanistic alterations throughout the AD continuum. Large-scale genome-wide association studies point out several genetic variants— TREM2, CD33, PILRA, CR1, MS4A, CLU, ABCA7, EPHA1 , and HLA-DRB5-HLA-DRB1 —potentially linked t...
Analysis of Dual Class I Histone Deacetylase and Lysine Demethylase Inhibitor Domatinostat (4SC-202) on Growth and Cellu...
...Published in Cancers
Central nervous system atypical teratoid/rhabdoid tumors (ATRTs) are rare and aggressive tumors with a very poor prognosis. Current treatments for ATRT include resection of the tumor, followed by systemic chemotherapy and radiation therapy, which have toxic side effects for young children. Gene expression analyses of human ATRTs and normal brain sa...
Emergent Properties of the HNF4α-PPARγ Network May Drive Consequent Phenotypic Plasticity in NAFLD
Published in Journal of Clinical Medicine
Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in adults and children. It is characterized by excessive accumulation of lipids in the hepatocytes of patients without any excess alcohol intake. With a global presence of 24% and limited therapeutic options, the disease burden of NAFLD is increasing. Thus, i...
