Published in Meta gene
Meta-analysis of genetic association studies is being increasingly used to assess phenotypic differences between genotype groups. When the underlying genetic model is assumed to be dominant or recessive, assessing the phenotype differences based on summary statistics, reported for individual studies in a meta-analysis, is a valid strategy. However,...
Published in Proceedings. Biological sciences
The human visual system represents summary statistical information (e.g. average) along many visual dimensions efficiently. While studies have indicated that approximately the square root of the number of items in a set are effectively integrated through this ensemble coding, how those samples are determined is still unknown. Here, we report that s...
Published in Current biology : CB
To overcome variability, estimate scene characteristics, and compress sensory input, perceptual systems pool data into statistical summaries. Despite growing evidence for statistical representations in perception, the underlying mechanisms remain poorly understood. One example of such representations occurs in auditory scenes, where background text...
The human visual system represents summary statistical information (e.g. average) along many visual dimensions efficiently. While studies have indicated that approximately the square root of the number of items in a set are effectively integrated through this ensemble coding, how those samples are determined is still unknown. Here, we report that s...
Published in Genetics
Genome-wide association studies (GWAS) have identified thousands of loci that are robustly associated with complex diseases. The use of linear mixed model (LMM) methodology for GWAS is becoming more prevalent due to its ability to control for population structure and cryptic relatedness and to increase power. The odds ratio (OR) is a common measure...
To understand visual consciousness, we must understand how the brain represents ensembles of objects at many levels of perceptual analysis. Ensemble perception refers to the visual system's ability to extract summary statistical information from groups of similar objects—often in a brief glance. It defines foundational limits on cognition, memory, ...
This study presents a method for genomic prediction that uses individual-level data and summary statistics from multiple populations. Genome-wide markers are nowadays widely used to predict complex traits, and genomic prediction using multi-population data are an appealing approach to achieve higher prediction accuracies. However, sharing of indivi...
Published in Frontiers in genetics
The relationship between growth and immune phenotypes has been presented in the context of physiology and energy allocation theory, but has rarely been explained genetically in humans. As more summary statistics of genome-wide association studies (GWAS) become available, it is increasingly possible to explore the genetic relationship between traits...
To understand visual consciousness, we must understand how the brain represents ensembles of objects at many levels of perceptual analysis. Ensemble perception refers to the visual system's ability to extract summary statistical information from groups of similar objects-often in a brief glance. It defines foundational limits on cognition, memory, ...
Published in Genetic epidemiology
Genome-wide association studies (GWAS) for complex diseases have focused primarily on single-trait analyses for disease status and disease-related quantitative traits. For example, GWAS on risk factors for coronary artery disease analyze genetic associations of plasma lipids such as total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycer...
