Published in Frontiers in immunology
The adaptive immune system generates an incredible diversity of antigen receptors for B and T cells to keep dangerous pathogens at bay. The DNA sequences coding for these receptors arise by a complex recombination process followed by a series of productivity-based filters, as well as affinity maturation for B cells, giving considerable diversity to...
Published in Genetic epidemiology
The heritability of most complex traits is driven by variants throughout the genome. Consequently, polygenic risk scores, which combine information on multiple variants genome-wide, have demonstrated improved accuracy in genetic risk prediction. We present a new two-step approach to constructing genome-wide polygenic risk scores from meta-GWAS summ...
Cet article présente les processus ponctuels sur réseaux linéiques pour la modélisation spatiale des fuites sur un réseau de distribution d'eau. Cette modélisation se fait sachant la position des capteurs de détection de fuites sur le réseau. Des statistiques exploratoires permettant la comparaison des observations avec la réalisation d'un processu...
Published in International Journal of Epidemiology
Background Observational associations between asthma and obesity are well established, but inferring causality is challenging. We leveraged publicly available summary statistics to ascertain the causal direction between asthma and obesity via Mendelian randomization in European-ancestry adults. Methods We performed two-sample bi-directional Mendeli...
Published in Proceedings of the National Academy of Sciences of the United States of America
Grouping is a perceptual process in which a subset of stimulus components (a group) is selected for a subsequent—typically implicit—perceptual computation. Grouping is a critical precursor to segmenting objects from the background and ultimately to object recognition. Here, we study grouping by color. We present subjects with 300-ms exposures of 12...
Grouping is a perceptual process in which a subset of stimulus components (a group) is selected for a subsequent-typically implicit-perceptual computation. Grouping is a critical precursor to segmenting objects from the background and ultimately to object recognition. Here, we study grouping by color. We present subjects with 300-ms exposures of 12...
Published in Nature Human Behaviour
A century after being predicted by theory, the authors detect and quantify the genomic signature of assortative mating in ~400,000 contemporary human genomes, and report new genetic evidence for assortative mating on height and educational attainment.
Published in Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Do we perceive fine details in the visual periphery? Here, we propose that phenomenology in the visual periphery can be characterized by an inflated sense of perceptual capacity, as observers overestimate the quality of their perceptual inputs. Distinct from the well-known perceptual phenomenon of 'filling-in' where perceptual content is generated ...
Published in Philosophical transactions of the Royal Society of London. Series B, Biological sciences
We contrast two theoretical positions on the relation between phenomenal and access consciousness. First, we discuss previous data supporting a mild Overflow position, according to which transient visual awareness can overflow report. These data are open to two interpretations: (i) observers transiently experience specific visual elements outside a...
This paper presents a novel approach for acoustic scene classification based on efficient acoustic feature extraction using spectro-temporal descriptors fusion. Grounded on the finding in neuroscience&mdash / &ldquo / auditory system summarizes the temporal details of sounds using time-averaged statistics to understand acoustic scenes&rdquo / , we ...
