Redmond, L Hockfield, S Morabito, M A
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
In the mammalian brain, an important phase of neurogenesis occurs postnatally in the subventricular zone (SVZ). This region consists of a heterogeneous population of cells, some mitotically active, others postmitotic. A subset of mitotically active SVZ precursor cells gives rise to a population of neurons that migrates over a long distance to their...
Doetsch, F Alvarez-Buylla, A
Published in
Proceedings of the National Academy of Sciences of the United States of America
Cells in the brains of adult mammals continue to proliferate in the subventricular zone (SVZ) throughout the lateral wall of the lateral ventricle. Here we show, using whole mount dissections of this wall from adult mice, that the SVZ is organized as an extensive network of chains of neuronal precursors. These chains are immunopositive to the polys...
Cabelli, R J Allendoerfer, K L Radeke, M J Welcher, A A Feinstein, S C Shatz, C J
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Neurotrophins play important roles in the survival, differentiation, and maintenance of CNS neurons. To begin to investigate specific roles for these factors in the mammalian visual system, we have examined the cellular localization of the neurotrophin receptor trkB within the developing cerebral cortex and thalamus of the ferret using extracellula...
Doetsch, F García-Verdugo, J M Alvarez-Buylla, A
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The adult mammalian subventricular zone (SVZ) contains stem cells that give rise to neurons and glia. In vivo, SVZ progeny migrate 3-8 mm to the olfactory bulb, where they form neurons. We show here that the SVZ of the lateral wall of the lateral ventricles in adult mice is composed of neuroblasts, glial cells, and a novel putative precursor cell. ...
Kuhn, H G Winkler, J Kempermann, G Thal, L J Gage, F H
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Neurons and glia are generated throughout adulthood from proliferating cells in two regions of the rat brain, the subventricular zone (SVZ) and the hippocampus. This study shows that exogenous basic fibroblast growth factor (FGF-2) and epidermal growth factor (EGF) have differential and site-specific effects on progenitor cells in vivo. Both growth...
Bernier, P J Parent, A
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The distribution of neurons expressing immunoreactivity for the protein Bcl-2 was studied in the brain of squirrel monkeys (Saimiri sciureus) of various ages. Several subsets of small and intensely immunoreactive neurons displaying an immature appearance were disclosed in the amygdala and piriform cortex. The piriform cortex exhibited clusters of v...
Zhang, D Mehler, M F Song, Q Kessler, J A
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Characterization of bone morphogenetic protein receptor (BMPR) expression during development is necessary for understanding the role of these factors during neural maturation. In this study, in situ hybridization analyses demonstrate that BMP-specific type I (BMPR-IA and BMPR-IB) and type II (BMPR-II) receptor mRNAs are expressed at significant lev...
Just, Lothar Olenik, Claudia Meyer, Dieter K.
Published in
Journal of Molecular Neuroscience
The proenkephalin (PEnk) gene is expressed in rats in the neocortical subventricular zone (nSVZ) of the lateral ventricle during the first postnatal week, when precursors of astro- and oligoglial cells of the rat neocortex proliferate in this area. To study the expression of the gene in the glial precursors, slices containing the nSVZ were prepared...
Kirschenbaum, B Doetsch, F Lois, C Alvarez-Buylla, A
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Neurons continue to be born in the subventricular zone (SVZ) of the lateral ventricles of adult mice. These cells migrate as a network of chains through the SVZ and the rostral migratory stream (RMS) into the olfactory bulb (OB), where they differentiate into mature neurons. The OB is the only known target for these neuronal precursors. Here, we sh...
Fricker, R A Carpenter, M K Winkler, C Greco, C Gates, M A Björklund, A
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Neural progenitor cells obtained from the embryonic human forebrain were expanded up to 10(7)-fold in culture in the presence of epidermal growth factor, basic fibroblast growth factor, and leukemia inhibitory growth factor. When transplanted into neurogenic regions in the adult rat brain, the subventricular zone, and hippocampus, the in vitro prop...
