Serra-Almeida, Catarina Saraiva, Cláudia Esteves, Marta Ferreira, Raquel Santos, Tiago Cristóvão, Ana Clara Bernardino, Liliana
Published in
Frontiers in Cell and Developmental Biology
C-terminal binding proteins (CtBPs) are transcriptional modulators that can regulate gene expression through the recruitment of a corepressor complex composed of chromatin-modifying enzymes and transcriptional factors. In the brain, CtBPs have been described as regulators of cell proliferation, differentiation, and survival. Nevertheless, the role ...
Mistry, Akshitkumar M. Mummareddy, Nishit Salwi, Sanjana Davis, Larry T. Ihrie, Rebecca A.
Published in
Frontiers in Oncology
Objective To determine the relationship between survival and glioblastoma distance from the ventricular-subventricular neural stem cell niche (VSVZ). Methods 502 pre-operative gadolinium-enhanced, T1-weighted MRIs with glioblastoma retrieved from an institutional dataset (n = 252) and The Cancer Imaging Atlas (n=250) were independently reviewed. Th...
Xie, Xuanhua P Laks, Dan R Sun, Daochun Poran, Asaf Laughney, Ashley M Wang, Zilai Sam, Jessica Belenguer, German Fariñas, Isabel Elemento, Olivier
...
Published in
Proceedings of the National Academy of Sciences of the United States of America
Adult neural stem cells (NSC) serve as a reservoir for brain plasticity and origin for certain gliomas. Lineage tracing and genomic approaches have portrayed complex underlying heterogeneity within the major anatomical location for NSC, the subventricular zone (SVZ). To gain a comprehensive profile of NSC heterogeneity, we utilized a well-validated...
Chongtham, Monika C. Wang, Haifang Thaller, Christina Hsiao, Nai-Hua Vachkov, Ivan H. Pavlov, Stoyan P. Williamson, Lorenz H. Yamashima, Tetsumori Stoykova, Anastassia Yan, Jun
...
Published in
Frontiers in Cell and Developmental Biology
The main stem cell niche for neurogenesis in the adult mammalian brain is the subventricular zone (SVZ) that extends along the cerebral lateral ventricles. We aimed at characterizing the initial molecular responses of the macaque monkey SVZ to transient, global cerebral ischemia. We microdissected tissue lining the anterior horn of the lateral vent...
Trova, Sara Bovetti, Serena Pellegrino, Giuliana Bonzano, Sara Giacobini, Paolo Peretto, Paolo
Published in
Frontiers in Neuroanatomy
Adult neurogenesis, a striking form of neural plasticity, is involved in the modulation of social stimuli driving reproduction. Previous studies on adult neurogenesis have shown that this process is significantly modulated around puberty in female mice. Puberty is a critical developmental period triggered by increased secretion of the gonadotropin ...
Ikegaya, Shunsuke Iga, Yurika Mikawa, Sumiko Zhou, Li Abe, Manabu Sakimura, Kenji Sato, Kohji Yamagishi, Satoru
Published in
Frontiers in Neuroscience
In the adult mouse brain, neurogenesis occurs mainly in the ventricular-subventricular zone (V-SVZ) and the subgranular zone of the hippocampal dentate gyrus. Neuroblasts generated in the V-SVZ migrate to the olfactory bulb via the rostral migratory stream (RMS) in response to guidance molecules, such as netrin-1. We previously showed that the rela...
Jiang, Haihui Yu, Kefu Li, Mingxiao Cui, Yong Ren, Xiaohui Yang, Chuanwei Zhao, Xuzhe Lin, Song
Published in
Frontiers in Oncology
Background This study was designed to explore the progression patterns of IDH-wildtype glioblastoma (GBM) at first recurrence after chemoradiotherapy. Methods Records from 247 patients who underwent progression after diagnosis of IDH-wildtype GBM was retrospectively reviewed. Progression patterns were classified as either local, distant, subependym...
Khozhai, L. I. Otellin, V. A.
Published in
Journal of Evolutionary Biochemistry and Physiology
AbstractThis study aimed to reveal parvalbumin (PVA) expression in cells of the subventricular zone (SVZ), identify the morphological type of these cells, and estimate the effect of acute hypoxia on the size of this cell population in the Wistar rat neonatal period. PVA-expressing cells were revealed immunohistochemically using Abcam rabbit polyclo...
Jung, Da Hee Pak, Malk Eun Lee, Hong Ju Ahn, Sung Min Yun, Young Ju Shin, Yong-Il Shin, Hwa Kyoung Lee, Seo-Yeon Choi, Byung Tae
Published in
Life
Electroacupuncture (EA) therapy via alternating current stimulation on the scalp over the motor cortex is used for the treatment of brain disorders. Perinatal hypoxia-ischemia (HI), a brain injury in newborns, leads to long-term neurologic complications. Here, we investigated whether EA could promote functional improvements and neurogenesis in a ne...
Pascale, Emilia Beclin, Christophe Fiorenzano, Alessandro Andolfi, Gennaro Erni, Andrea De Falco, Sandro Minchiotti, Gabriella Cremer, Harold Fico, Annalisa
Published in
Stem Cell Reports
In this study, Fico, Beclin, and colleagues show that the long non-coding RNA T-UCstem1 is expressed in the forebrain neurogenic lineage generating interneurons for the postnatal olfactory bulb. Increased T-UCstem1 levels in neural stem cells induced progenitor proliferation at the expense of neuron production, whereas its downregulation caused the...
