Jiang, Xuejie Mak, Po Yee Mu, Hong Tao, Wenjing Mak, Duncan H Kornblau, Steven Zhang, Qi Ruvolo, Peter Burks, Jared K Zhang, Weiguo
...
Published in
Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose: Wnt/β-catenin signaling is required for leukemic stem cell function. FLT3 mutations are frequently observed in acute myeloid leukemia (AML). Anomalous FLT3 signaling increases β-catenin nuclear localization and transcriptional activity. FLT3 tyrosine kinase inhibitors (TKI) are used clinically to treat FLT3-mutated AML patients, but with l...
Kim, Moon Jong Xia, Bo Suh, Han Na Lee, Sung Ho Jun, Sohee Lien, Esther M. Zhang, Jie Chen, Kaifu Park, Jae-Il
Published in
Developmental cell
Controlling the proliferation of self-renewing cells is crucial for tissue homeostasis and regeneration. Kim et al. show that PAF (PCNA-associated factor), dispensable for intestinal homeostasis, is required to positively regulate the proliferation of self-renewing cells via Myc transactivation during intestinal regeneration and tumorigenesis.
Wu, Xiaoli Liu, Wenjun Ding, Hao
Published in
Genesis (New York, N.Y. : 2000)
PDGF-C, a member of the platelet-derived growth factor (PDGF) family, plays important roles in the development of craniofacial structures, the neural system, the vascular system, and tumors. PDGF-C could also be required for the regulation of certain types of stem or progenitor cells as suggested by its expression in the regions where these cells a...
Petersen, Mark A Ryu, Jae Kyu Chang, Kae-Jiun Etxeberria, Ainhoa Bardehle, Sophia Mendiola, Andrew S Kamau-Devers, Wanjiru Fancy, Stephen P J Thor, Andrea Bushong, Eric A
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Published in
Neuron
Blood-brain barrier (BBB) disruption alters the composition of the brain microenvironment by allowing blood proteins into the CNS. However, whether blood-derived molecules serve as extrinsic inhibitors of remyelination is unknown. Here we show that the coagulation factor fibrinogen activates the bone morphogenetic protein (BMP) signaling pathway in...
Petersen, Mark A Ryu, Jae Kyu Chang, Kae-Jiun Etxeberria, Ainhoa Bardehle, Sophia Mendiola, Andrew S Kamau-Devers, Wanjiru Fancy, Stephen PJ Thor, Andrea Bushong, Eric A
...
Blood-brain barrier (BBB) disruption alters the composition of the brain microenvironment by allowing blood proteins into the CNS. However, whether blood-derived molecules serve as extrinsic inhibitors of remyelination is unknown. Here we show that the coagulation factor fibrinogen activates the bone morphogenetic protein (BMP) signaling pathway in...
Leśniak, Wiesława Wilanowski, Tomasz Filipek, Anna
Published in
Biological Chemistry
The Ca2+-binding protein, S100A6, belongs to the S100 family. Binding of Ca2+ induces a conformational change, which causes an increase in the overall S100A6 hydrophobicity and allows it to interact with many targets. S100A6 is expressed in different normal tissues and in many tumors. Up to now it has been shown that S100A6 is involved in cell prol...
Szivek, John A Ruth, John T Heden, Greg J Martinez, Michael A Diggins, Nicklaus H Wenger, Karl H
Published in
Journal of biomedical materials research. Part B, Applied biomaterials
Two complete unicondylar surface replacement scaffold designs to support tissue-engineered cartilage growth that utilized adult endogenous stem cells were 3D printed and tested in a dog stifle model. Integrated rosette strain gauges were calibrated and used to determine shear loading within stifle joints for up to 12 months. An activity index that ...
Heitz, J Plamadeala, C Wiesbauer, M Freudenthaler, P Wollhofen, R Jacak, J Klar, T A Magnus, B Köstner, D Weth, A
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Published in
Journal of biomedical materials research. Part A
The main aim of this work was to stimulate bone-forming cells to produce three-dimensional networks of mineralized proteins such as those occurring in bones. This was achieved by a novel approach using a specific type of mesenchymal progenitor cells (i.e., primary fibroblast cells from human hair roots) seeded on to polymer scaffolds. We wrote poly...
Rogler, Charles E Bebawee, Remon Matarlo, Joe Locker, Joseph Pattamanuch, Nicole Gupta, Sanjeev Rogler, Leslie E
Published in
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Recent investigations have reported many markers associated with human liver stem/progenitor cells, "oval cells," and identified "niches" in diseased livers where stem cells occur. However, there has remained a need to identify entire lineages of stem cells as they differentiate into bile ducts or hepatocytes. We have used combined immunohistochemi...
Bock, Karl Walter
Published in
Biological Chemistry
Metabolism of aryl hydrocarbons and toxicity of dioxins led to the discovery of the aryl hydrocarbon receptor (AHR). Tremendous advances have been made on multiplicity of AHR signaling and identification of endogenous ligands including the tryptophan metabolites FICZ and kynurenine. However, human AHR functions are still poorly understood due to ma...
