ObjectivesTo investigate the applicability, localization, biodistribution and toxicity of self assembled ionically sodium alginate cross-linked AmB loaded glycol chitosan stearate nanoparticles for effective management of visceral leishmaniasis.MethodsHere, we fabricated Amphotericin B (AmB) encapsulated sodium alginate-glycol chitosan stearate nan...
International journal of pharmaceutical investigation
The said promising formulation (F4) would be able to offer benefits such as increase residence time, prolonged drug release, reduction in frequency of administration and thereby definitely prove to improve the patient compliance.
The purpose of this study is to characterize the inter-grade and inter-batch variability of sodium alginate used in the formulation of matrix tablets. Four different grades and three batches of one grade of sodium alginate were used to prepare matrix tablets. Swelling, erosion, and drug release tests of sodium alginate matrix tablets were conducted...
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
The safety of 0.6% SA solution as a submucosal injection material was confirmed and it is suggested that its efficacy should be investigated in a larger number of cases.
Nanomedicine (London, England)
The QS-NPs synthesized are safe, less toxic and highly effective compared with QS.
In this paper, the addition of sodium carboxymethyl cellulose (NACMC) and cobalt ions to alginate gel significantly improved the inner and outer surface properties of membranes and the activity of the enzymes. The results showed the optimization was sodium alginate (SA) and NACMC at ratio 1:1, and the concentration of CoCl2 at 0.05mol/L. The combin...
Artificial cells, nanomedicine, and biotechnology
Gastroretentive formulation was successfully optimized by a three-factor, three-level Box-Behnken design and found to be useful.
The objectives of this study were to develop and to characterize sodium alginate based matrix-type transdermal films of metoclopramide hydrochloride (MTC) in order to improve patient compliance to treatment. The suitability of sodium alginate was shown to be a natural film former in terms of the physicochemical, mechanical, and bioadhesive features...
Eudragit E (EE)-sodium alginate (SA) polyelectrolyte complexes (PECs) were prepared at pH 4 and 5.8 using sodium alginate of high (SAH) and low viscosity (SAL). The optimum EE-SA complexation mass ratio was determined using viscosity measurements. Interactions between EE and SA in PECs were characterized by Fourier transform infra-red spectroscopy ...
Journal of biomaterials science. Polymer edition
This work describes the preparation of magnetic and pH-sensitive beads based on κ-carrageenan and sodium alginate for use as drug-targeting carriers. Physical cross-linking using K(+)/Ca(2+) ions was applied to obtain ionic cross-linked magnetic hydrogel beads. The produced magnetite beads were thoroughly characterized by TEM, SEM/EDS, XRD, FTIR, a...