Drug design, development and therapy
The aim of this work was to design and evaluate effervescent floating gastro-retentive drug delivery matrix tablets with sustained-release behavior using a binary mixture of hydroxyethyl cellulose and sodium alginate. Pentoxifylline was used as a highly water-soluble, short half-life model drug with a high density. The floating capacity, swelling, ...
Drug development and industrial pharmacy
Alginates are natural polymers widely used in the food industry because of their biocompatible, biodegradable character, nontoxicity and easy availability. The bioadhesive character of alginates makes them useful in the pharmaceutical industry as well. The application areas of sodium alginate-based drug delivery systems are many and these systems c...
ObjectivesTo investigate the applicability, localization, biodistribution and toxicity of self assembled ionically sodium alginate cross-linked AmB loaded glycol chitosan stearate nanoparticles for effective management of visceral leishmaniasis.MethodsHere, we fabricated Amphotericin B (AmB) encapsulated sodium alginate-glycol chitosan stearate nan...
International journal of pharmaceutical investigation
The said promising formulation (F4) would be able to offer benefits such as increase residence time, prolonged drug release, reduction in frequency of administration and thereby definitely prove to improve the patient compliance.
The purpose of this study is to characterize the inter-grade and inter-batch variability of sodium alginate used in the formulation of matrix tablets. Four different grades and three batches of one grade of sodium alginate were used to prepare matrix tablets. Swelling, erosion, and drug release tests of sodium alginate matrix tablets were conducted...
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
The safety of 0.6% SA solution as a submucosal injection material was confirmed and it is suggested that its efficacy should be investigated in a larger number of cases.
Nanomedicine (London, England)
The QS-NPs synthesized are safe, less toxic and highly effective compared with QS.
In this paper, the addition of sodium carboxymethyl cellulose (NACMC) and cobalt ions to alginate gel significantly improved the inner and outer surface properties of membranes and the activity of the enzymes. The results showed the optimization was sodium alginate (SA) and NACMC at ratio 1:1, and the concentration of CoCl2 at 0.05 mol/L. The combi...
Artificial cells, nanomedicine, and biotechnology
Gastroretentive formulation was successfully optimized by a three-factor, three-level Box-Behnken design and found to be useful.
Eudragit E (EE)-sodium alginate (SA) polyelectrolyte complexes (PECs) were prepared at pH 4 and 5.8 using sodium alginate of high (SAH) and low viscosity (SAL). The optimum EE-SA complexation mass ratio was determined using viscosity measurements. Interactions between EE and SA in PECs were characterized by Fourier transform infra-red spectroscopy ...