Dufour, Inès Venot, Quitterie Aydin, Selda Demoulin, Nathalie Canaud, Guillaume Morelle, Johann
Published in
American journal of kidney diseases : the official journal of the National Kidney Foundation
Despite optimal anticoagulation and blood pressure control, patients with antiphospholipid syndrome (APS) nephropathy frequently progress to kidney failure, and recurrence after transplantation is common. The mTORC (mechanistic target of rapamycin complex) pathway was recently identified as a potential intermediate and a therapeutic target in vascu...
Zhang, Zhi-Hua Li, Li Xin Li, Ping Lv, Shao-Cheng Pan, Bing He, Qiang
Published in
Journal of investigative surgery : the official journal of the Academy of Surgical Research
Previous studies have indicated that sirolimus (SRL) may be effective for HCC patients undergoing liver transplantation (LT). However, the following results are still contradictory and do not have a clear conclusion. Therefore, we conducted an updated meta-analysis by retrieving published data in EMBASE, PubMed, and the Cochrane Library up to Octob...
Peng, Suhua Yang, Kaiying Xu, Zhicheng Chen, Siyuan Ji, Yi
Published in
Journal of paediatrics and child health
Kaposiform haemangioendothelioma (KHE) is a rare, potentially life-threatening vascular tumour that is often associated with thrombocytopenia and coagulopathy, known as the Kasabach-Merritt phenomenon (KMP). Because of the rarity and complexity of KHE, the optimal paradigm for treating KHE has yet to be elucidated. We aim to assess the efficacy and...
Lee, Eun Jin Kim, Hyun-Ki Ahn, Sunyoung Lee, Woochang Kim, Hyun Soo Chun, Sail Min, Won-Ki
Published in
Journal of clinical laboratory analysis
We evaluated the analytical performance of a newly developed electrochemiluminescence immunoassay for everolimus and sirolimus compared to that of liquid chromatography-tandem mass spectrometry (LC-MS/MS). According to Clinical and Laboratory Standards Institute guidelines, the analytical performance including precision, recovery, linearity, and ca...
Alfano, Gaetano Fontana, Francesco Mori, Giacomo Vicari, Emanuela Dolci, Giovanni Franceschini, Erica Guaraldi, Giovanni Mussini, Cristina Cappelli, Gianni
Published in
International journal of STD & AIDS
Asleh, Rabea Clavell, Alfredo L Pereira, Naveen L Smith, Byron Briasoulis, Alexandros Alnsasra, Hilmi Kremers, Walter K Habermann, Thomas M Otley, Clark C Li, Xin
...
Published in
Journal of the American College of Cardiology
Malignancy is a major cause of late post-heart transplantation (HT) mortality. Sirolimus (SRL) exerts antiproliferative properties and its long-term use in HT as primary immunosuppression (IS) is associated with decreased mortality risk that is not fully explained by attenuation of cardiac allograft vasculopathy progression. This study sought to ex...
Golubović, Bojana Vučićević, Katarina Radivojević, Dragana Kovačević, Sandra Vezmar Prostran, Milica Miljković, Branislava
Published in
Journal of Medical Biochemistry
Background Due to wide intra- and inter-individual pharmacokinetic variability and narrow therapeutic index of sirolimus, the therapeutic drug monitoring (TDM) of sirolimus with detailed biochemical and clinical monitoring is necessary for dose individualization in kidney transplant patients. The purpose of the study was to explore and identify fac...
Parker, Victoria E. R. Keppler-Noreuil, Kim M. Faivre, Laurence Luu, Maxime Oden, Neal L. De Silva, Leena Sapp, Julie C. Andrews, Katrina Bardou, Marc Chen, Kong Y.
...
Published in
Genetics in Medicine
PurposePIK3CA-related overgrowth spectrum (PROS) encompasses a range of debilitating conditions defined by asymmetric overgrowth caused by mosaic activating PIK3CA variants. PIK3CA encodes the p110α catalytic subunit of phosphatidylinositol-3-kinase (PI3K), a critical transducer of growth factor signaling. As mTOR mediates the growth-promoting acti...
Tam, Yu Tong Repp, Lauren Ma, Zhi-Xiong Feltenberger, John B. Kwon, Glen S.
Published in
Pharmaceutical Research
PurposeTo prepare an oligo(lactic acid)8-rapamycin prodrug (o(LA)8-RAP)-loaded poly(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA) micelle for injection and characterize its compatibility and performance versus a RAP-loaded PEG-b-PLA micelle for injection in vitro and in vivo.MethodsMonodisperse o(LA)8 was coupled on RAP at the C-40 via DCC/D...
Prostyakova, A. I. Zybin, D. I. Kapustin, D. V.
Published in
Pharmaceutical Chemistry Journal
Drug elution profiles must be studied in vitro to optimize a polymer-drug formulation during development of drug-eluting stents (DESs). Results from HPLC assays of drug contents and elution kinetics from a biodegradable sirolimus coating and a stable zotarolimus coating on coronary DESs are presented. Drug contents were assessed for crimped stents ...
