Paiva, Mayara Rodrigues Brandão De Vasconcelos-Santos, Daniel Vítor Vieira, Lorena Carla Fialho, Sílvia Ligório Silva-Cunha, Armando
Published in
AAPS PharmSciTech
Non-infectious uveitis, an ocular inflammatory condition that affects the iris, ciliary body, choroid, and adjacent tissues (retina, optic nerve, and vitreous), is an important cause of blindness worldwide. Sirolimus (SRL), a potent immunomodulatory drug, has shown promising results in the treatment of inflammatory ocular diseases. Despite this the...
Kanunnikov, M M Rakhmanova, J Z Levkovsky, N V Vafina, A I Goloshapov, O V Shchegoleva, T S Vlasova, Yu Yu Paina, O V Morozova, E V Zubarovskaya, L S
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Published in
Clinical transplantation
Transplant-associated thrombotic microangiopathy (TA-TMA) is a specific complication of allogeneic hematopoietic cell transplantation with a multifactorial etiology. There is little evidence published regarding the efficacy and factors influencing the outcome of substitution of calcineurin inhibitors (CNIs) with other agentsas a widely accepted pra...
Wu, Chanyuan Wang, Qian Xu, Dong Li, Mengtao Zeng, Xiaofeng
Published in
Rheumatology (Oxford, England)
Connective tissue disease-related thrombocytopenia (CTD-TP) is a problematic disorder in clinical practice. Because the first-line therapy of glucocorticoid and/or immunosuppressants is not effective for refractory cases, alternative treatment approaches are urgently needed. The present study investigated the efficacy and safety of sirolimus in ref...
Smrke, Alannah M Huang, Paul H Jones, Robin L
Published in
Cancer
Stacchiotti, Silvia Simeone, Noemi Lo Vullo, Salvatore Baldi, Giacomo G Brunello, Antonella Vincenzi, Bruno Palassini, Elena Dagrada, GianPaolo Collini, Paola Morosi, Carlo
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Published in
Cancer
The objective of this study was to report on a retrospective series of patients with epithelioid hemangioendothelioma (EHE) who received treatment with sirolimus within the Italian Rare Cancer Network. From January 2005, 38 adult patients with advanced EHE received continuous-dosing sirolimus, 5 mg daily, until they developed either toxicity or dis...
Lee, Kwang-Woong Kim, Seong Hoon Yoon, Kyung Chul Lee, Jeong-Moo Cho, Jae-Hyung Hong, Suk Kyun Yi, Nam-Joon Han, Sung-Sik Park, Sang-Jae Suh, Kyung-Suk
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Published in
Journal of Clinical Medicine
Sirolimus (SRL) has been reported to benefit patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). This study aimed to compare SRL with tacrolimus (TAC) in living-donor LT (LDLT) recipients beyond the Milan criteria. This study was initially designed to enrol 45 recipients who underwent LDLT for HCC beyond the Milan cri...
Dong, Jianyong Han, Deting Wang, Desheng Lu, Huijun Wang, Xiaoliang
Published in
Medicine
The pathophysiologic of vascular malformations is still unclear, and the treatment of vascular malformations is a challenge. With improvement in the understanding of pathogenesis of vascular malformations, sirolimus has been a promising and effective treatment. As so far, there is absent convincing evidence to confirm the efficacy of sirolimus for ...
Peng, Liying Wu, Chanyuan Hong, Ruping Sun, Yiduo Qian, Junyan Zhao, Jiuliang Wang, Qian Tian, Xinping Wang, Yanhong Li, Mengtao
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Published in
Therapeutic Advances in Musculoskeletal Disease
Objective: To provide real-world data and summarize current clinical evidence on the efficacy and safety of sirolimus in active systemic lupus erythematosus (SLE) patients. Methods: This was a prospective real-world clinical study. Included SLE patients should have Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) ⩾ 2. They were ...
Verheye, Stefan; Wlodarczak, Adrian; Montorsi, Piero; Torzewski, Jan; Bennett, Johan; 101177; Haude, Michael; Starmer, Gregory; Buck, Thomas; Wiemer, Marcus; Nuruddin, Amin AB;
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OBJECTIVES: We aimed to assess the safety and performance of the Magmaris sirolimus-eluting bioresorbable magnesium scaffold in a large patient population. BACKGROUND: Magmaris has shown good outcomes in small-sized controlled trials, but further data are needed to confirm its usability, safety, and performance. METHODS: BIOSOLVE-IV is an internati...
Chen, Xiao Wang, Dong-Dong Xu, Hong Li, Zhi-Ping
Published in
The Journal of international medical research
Sirolimus has been used to treat paediatric kaposiform haemangioendothelioma patients. However, there is considerable pharmacokinetic variability among individuals, and it is difficult to develop an initial dosing regimen. The goal of the present study is to recommend an initial sirolimus dose in paediatric kaposiform haemangioendothelioma patients...