The aetiology of chronic leg ulcer in patients with sickle cell anaemia is multifactorial and complex, prevention and management is a daunting task. Micronutrients and antioxidants contribute to the pathogenesis of sickle cell disease and chronic leg ulcers. Therefore, this study was carried out to determine the serum levels of zinc, copper and vit...
Published in British journal of haematology
Published in British journal of haematology
Hypoxia and hemoglobin S polymerization are two triggers responsible for initiating erythrocyte sickling and the consequent clinical sickle cell anemia (SCA) events. The objective of this study was to investigate the expression of hypoxia-responsive genes in SCA, testing for correlation with the clinical-laboratorial characteristics of the patient ...
Published in Journal of tropical pediatrics
Hydroxyurea has been shown to positively modify sickle cell disease pathogenesis, but its use is low among Nigerian sickle cell anaemia (SCA) patients because of effectiveness and safety concerns. We conducted a quasi-experimental study to evaluate the effectiveness and safety of hydroxyurea in 54 SCA children aged 4-17 years. Clinical and haematol...
Published in Journal of clinical periodontology
To investigate the association among iron overload, periodontal status, and periodontitis progression rate in sickle cell anaemia (SCA). This case series evaluated 123 patients. Clinical attachment level (CAL) and probing depth (PD) were evaluated at six sites per tooth. Alveolar bone loss was estimated using periapical radiography. Study outcomes ...
Published in Transactions of the Royal Society of Tropical Medicine and Hygiene
Short-term emergency department (ED) observation care may prevent prolonged and unnecessary hospital admission in patients with sickle pain. This study highlights the outcomes of short-term ED care of acute pain in children with sickle cell disease (SCD). Children aged 6 mo to 19 y with SCD and painful crises who were managed by short-term ED care ...
Published in British journal of haematology
Published in European journal of case reports in internal medicine
Pulmonary arterial hypertension (PAH) is one of the main complications of sickle cell disease (SCD) and imparts significant risk during pregnancy. Here, we report the outcome of undetected PAH in a pregnant woman with SCD. The patient presented with severe progressive dyspnoea with echocardiographic findings of high pressure in the pulmonary artery...
Published in The Pan African Medical Journal
Introduction Opioids are a mainstay in sickle cell disease (SCD) pain care. Opioids are known to cause physical and/or psychological dependence. Increasingly, a significant number of Nigerian SCD patients ("Pentaholics") are observed to abuse pentazocine. This trend is associated with new patterns of medical complications. This study aimed to descr...
Published in Journal of clinical pharmacy and therapeutics
Hyperhaemolysis syndrome (HHS) of sickle cell anaemia (SCA) is a life-threatening condition characterized by accelerated destruction of red blood cells typically following blood transfusions. Optimal treatment strategies have not been determined; therefore, reports utilizing novel therapies are needed. A 19-year-old African American man with SCA ex...
