Han, S Suzuki-Kerr, H Suwantika, M Telang, R S Gerneke, D A Anekal, P V Bird, P Vlajkovic, S M Thorne, P R
Published in
Journal of the Association for Research in Otolaryngology : JARO
Intratympanic injection is a clinically used approach to locally deliver therapeutic molecules to the inner ear. Drug diffusion, at least in part, is presumed to occur through the round window membrane (RWM), one of the two openings to the inner ear. Previous studies in human temporal bones have identified a three-layered structure of the RWM with ...
Balistreri, Carmela Rita Ammoscato, Claudia Leonarda Scola, Letizia Fragapane, Tiziana Giarratana, Rosa Maria Lio, Domenico Piccione, Maria
Published in
Genes
Congenital heart defects (CHDs) are present in about 40-60% of newborns with Down syndrome (DS). Patients with DS can also develop acquired cardiac disorders. Mouse models suggest that a critical 3.7 Mb region located on human chromosome 21 (HSA21) could explain the association with CHDs. This region includes a cluster of genes (IFNAR1, IFNAR2, IFN...
Hampton, Jordan O Jones, Bidda McGreevy, Paul D
Published in
Animals : an open access journal from MDPI
"Social license to operate" (SLO) refers to the implicit process by which a community gives an industry approval to conduct its current business activities. It has become an important focus for many natural resource management fields (especially mining), but there is less awareness of its role in animal use industries. This article describes how an...
Luparello, Claudio Mauro, Manuela Arizza, Vincenzo Vazzana, Mirella
Published in
Biology
Histone deacetylases (HDACs) are key components of the epigenetic machinery controlling gene expression. They are involved in chromatin remodeling events via post-translational histone modifications but may also act on nonhistone proteins, influencing many fundamental cellular processes. Due to the key involvement of HDACs in serious human patholog...
Storck, Philip Umstätter, Florian Wohlfart, Sabrina Domhan, Cornelius Kleist, Christian Werner, Julia Brandenburg, Klaus Zimmermann, Stefan Haberkorn, Uwe Mier, Walter
...
Published in
Antibiotics (Basel, Switzerland)
The increasing number of infections caused by multidrug-resistant bacteria requires an intensified search for new antibiotics. Pep19-4LF is a synthetic antimicrobial peptide (GKKYRRFRWKFKGKLFLFG) that was previously designed with the main focus on high antimicrobial activity. The hydrophobic motif, LFLFG, was found to be essential for antimicrobial...
El Aayadi, Soufiane Araba, Abdelilah Jouven, Magali
Published in
Cahiers Agricultures
Dans les régions de montagne, la pérennité des systèmes d’élevage extensifs constitue un enjeu socio-économique et écologique majeur. Notre étude a pour objectif d’analyser la diversité des systèmes d’élevage de petits ruminants dans le Haut Atlas central du Maroc, en fonction de l’altitude. Pour cela, des enquêtes ont été réalisées auprès de 90 él...
Wang, Bing Yuan Mu, Yu Lian Li, Kui Liu, Zhi Guo
Published in
Yi chuan = Hereditas
干细胞技术是近年来被广泛应用于生命科学领域的重要技术。获取具有无限增殖能力和分化能力的干细胞系主要有3种途径:(1)从胚胎分离胚胎干细胞;(2)从成体组织分离成体干细胞;(3)通过体外诱导体细胞重编程为诱导多能干细胞。在农业领域中,畜禽干细胞的分离、培养、建系有望显著提升体细胞克隆和细胞水平基因修饰的效率;干细胞体外诱导配子技术能够极大简化基因编辑畜禽的制备流程,提升制备效率。同时,通过结合基因编辑、显微注射、干细胞移植、胚胎移植等技术,干细胞技术在基因编辑动物的生产、组织和器官的供体制备、体外配子诱导及遗传重组胚胎制备、疾病治疗靶点的筛选,以及新药药理研究等方面都具有极大的应用潜力,对农业动物的遗传改良、疾病防治具有重要意义。本文综述了干细胞相关研究在农业动物包括猪(Sus scrofa)...
Ninyio, Nathaniel Nyakaat Ho, Kok Lian Omar, Abdul Rahman Tan, Wen Siang Iqbal, Munir Mariatulqabtiah, Abdul Razak
Published in
Vaccines
Epizootics of highly pathogenic avian influenza (HPAI) have resulted in the deaths of millions of birds leading to huge financial losses to the poultry industry worldwide. The roles of migratory wild birds in the harbouring, mutation, and transmission of avian influenza viruses (AIVs), and the lack of broad-spectrum prophylactic vaccines present im...
Zozo, R. Sabra, L. Adediran, A. Opaluwah, A. Feye, G. Dror, Iddo Bokanga, M. Akem, C.
African Development Bank / Internal Review
Yang, Hua Ma, Jianyu Wan, Zhen Wang, Qi Wang, Zhibo Zhao, Jie Wang, Feng Zhang, Yanli
Published in
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Spermatogenesis is an important biological process in male reproduction. The interaction between male germ cells and somatic cells during spermatogenesis, is necessary for male reproductive activities. This cellular heterogeneity has made it difficult to profile distinct cell types at different stages of development. Here, we present the first comp...