Published in Automatica
A general analysis theory is presented which can incorporate robust stability or robust performance defined in H ∞ or μ framework for sequential design purposes. As a result, a methodology for sequential design of robust decentralized controllers is proposed. To do so, new formulations of linear fractional transformation of complementary sensitivit...
A number of active site mutants of human Alpha class glutathione transferase A1-1 (hGST A1-1) were made and characterized to determine the structural determinants for alkenal activity. The choice of mutations was based on primary structure alignments of hGST A1-1 and the Alpha class enzyme with the highest alkenal activity, hGST A4-4, from three di...
Stallard (1998, Biometrics 54, 279-294) recently used Bayesian decision theory for sample-size determination in phase II trials. His design maximizes the expected financial gains in the development of a new treatment. However, it results in a very high probability (0.65) of recommending an ineffective treatment for phase III testing. On the other h...
Published in Statistical Methods and Applications
We consider the situation where one wants to maximise a functionf(θ,x) with respect tox, with θ unknown and estimated from observationsyk. This may correspond to the case of a regression model, where one observesyk=f(θ,xk)+εk, with εk some random error, or to the Bernoulli case whereyk∈{0, 1}, with Pr[yk=1|θ,xk|=f(θ,xk). Special attention is given ...
Classical regression analysis is usually performed in two steps. In a first step an appropriate model is identified to describe the data generating process and in a second step statistical inference is performed in the identified model. An intuitively appealing approach to the design of experiment for these different purposes are sequential strateg...
We consider a parameter estimation problem with independent observations where one samples from a finite population of independent and identically distributed experimental conditions X. The size of the population is N but only n samples, a proportion alpha of N, can be used. The quality of a sample is measured by a regular optimality criterion phi(...
Under the condition that the design space is finite, new sufficient conditions for the strong consistency and asymptotic normality of the least-squares estimator in nonlinear stochastic regression models are derived. Similar conditions are obtained for the maximum-likelihood estimator in Bernoulli type experiments. Consequences on the sequential de...
We present new conditions for the strong consistency and asymptotic normality of the least squares estimator in nonlinear stochastic models when the design variables vary in a finite set. The application to self-tuning optimisation is considered, with a simple adaptive strategy that guarantees simultaneously the convergence to the optimum and the s...
A design method presented in a previous paper for the sequential generation of observation sites used for the inversion of a prediction model is extended to cope with practical issues such as delayed observations and design of batches of imposed size. The final objective of the construction is to be able to associate with any target T in the output...
Optimal design under a cost constraint is considered, with a scalar coefficient setting the compromise between information (i.e., precision of the estimation of the model parameters) and cost. For suitable cost functions, by increasing the value of the coefficient one can force the support points of an optimal design measure to concentrate around p...
