Published in Statistical methods in medical research
Response-adaptive designs are used in phase III clinical trials to allocate a larger number of patients to the better treatment arm. Optimal designs are explored in the recent years in the context of response-adaptive designs, in the frequentist view point only. In the present paper, we propose some response-adaptive designs for two treatments base...
Published in Statistical methods in medical research
The process of screening agents one-at-a-time under the current clinical trials system suffers from several deficiencies that could be addressed in order to extend financial and patient resources. In this article, we introduce a statistical framework for designing and conducting randomized multi-arm screening platforms with binary endpoints using B...
The total entropy utility function is considered for the dual purpose of Bayesian design for model discrimination and parameter estimation. A sequential design setting is proposed where it is shown how to efficiently estimate the total entropy utility for a wide variety of data types. Utility estimation relies on forming particle approximations to ...
Published in Statistical methods in medical research
We develop a nature-inspired stochastic population-based algorithm and call it discrete particle swarm optimization to find extended two-stage adaptive optimal designs that allow three target response rates for the drug in a phase II trial. Our proposed designs include the celebrated Simon's two-stage design and its extension that allows two target...
Published in The International Journal of Biostatistics
In phase II and/or III clinical trial study, there are several competing treatments, the goal is to assess the performances of the treatments at the end of the study, the trial design aims to minimize risks to the patients in the trial, according to some given allocation optimality criterion. Recently, a new type of clinical trial, the staggered-st...
Published in Clinical trials (London, England)
Tragically, the outbreak of Ebola that started in West Africa in 2014 has been far more extensive and damaging than any previous outbreaks. The duration of the outbreak has, for the first time, allowed the clinical evaluation of Ebola treatments. This article discusses the designs used for two such clinical trials which have recruited patients in L...
Due to performance and certification criteria, complex mechanical systems have to take into account several constraints, which can be associated with a series of performance functions. Different software are generally used to evaluate such functions, whose computational cost can vary a lot. In conception or reliability analysis, we thus are interes...
Due to performance and certification criteria, complex mechanical systems have to take into account several constraints, which can be associated with a series of performance functions. Different software are generally used to evaluate such functions, whose computational cost can vary a lot. In conception or reliability analysis, we thus are interes...
Due to performance and certification criteria, complex mechanical systems have to take into account several constraints, which can be associated with a series of performance functions. Different software are generally used to evaluate such functions, whose computational cost can vary a lot. In conception or reliability analysis, we thus are interes...
Due to performance and certification criteria, complex mechanical systems have to take into account several constraints, which can be associated with a series of performance functions. Different software are generally used to evaluate such functions, whose computational cost can vary a lot. In conception or reliability analysis, we thus are interes...
