Bogeska, Ruzhica Mikecin, Ana-Matea Kaschutnig, Paul Fawaz, Malak Büchler-Schäff, Marleen Le, Duy Ganuza, Miguel Vollmer, Angelika Paffenholz, Stella V Asada, Noboru
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Published in
Cell stem cell
Hematopoietic stem cells (HSCs) mediate regeneration of the hematopoietic system following injury, such as following infection or inflammation. These challenges impair HSC function, but whether this functional impairment extends beyond the duration of inflammatory exposure is unknown. Unexpectedly, we observed an irreversible depletion of functiona...
chen;, guofang
Embryonic stem cells (ESCs) are a type of cells capable of self-renewal and multi-directional differentiation. The self-renewal of ESCs is regulated by factors including signaling pathway proteins, transcription factors, epigenetic regulators, cytokines, and small molecular compounds. Similarly, non-coding RNAs, small RNAs, and microRNAs (miRNAs) a...
Tournaire, Guillaume Loopmans, Shauni Stegen, Steve Rinaldi, Gianmarco Eelen, Guy Torrekens, Sophie Moermans, Karen Carmeliet, Peter Ghesquière, Bart Thienpont, Bernard
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Published in
Cell Reports
Blocking mitochondrial respiration decreases proliferation in tumor cells but not in stem cells, although mechanistic insight is lacking. Tournaire et al. report that skeletal progenitors bypass this inhibition by reversing succinate dehydrogenase activity and using alternative NAD+ regenerating pathways. This metabolic plasticity maintains prolife...
Tournaire, Guillaume; Loopmans, Shauni; 111980; Stegen, Steve; 72875; Rinaldi, Gianmarco; Eelen, Guy; 33397; Torrekens, Sophie; Moermans, Karen; 25241; Carmeliet, Peter; 21003; Ghesquiere, Bart; Thienpont, Bernard; 48367;
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A functional electron transport chain (ETC) is crucial for supporting bioenergetics and biosynthesis. Accordingly, ETC inhibition decreases proliferation in cancer cells but does not seem to impair stem cell proliferation. However, it remains unclear how stem cells metabolically adapt. In this study, we show that pharmacological inhibition of compl...
An, Shiyu Yao, Dan Zhang, Wenyi Sun, Hao Yu, Tianyi Jia, Ruizhe Yang, Yang
Published in
Frontiers in Genetics
Extended pluripotent stem cells (EPS cells) have unlimited self-renewal ability and the potential to differentiate into mesodermal, ectodermal, and endodermal cells. Notably, in addition to developing the embryonic (Em) lineages, it can also make an effective contribution to extraembryonic (ExEm) lineages both in vitro and in vivo. However, multipl...
guo;, jing
Transient receptor potential (TRP) ion channels are cationic permeable proteins located on the plasma membrane. TRPs are cellular sensors for perceiving diverse physical and/or chemical stimuli; thus, serving various critical physiological functions, including chemo-sensation, hearing, homeostasis, mechano-sensation, pain, taste, thermoregulation, ...
Chou, Fu-Sheng Chen, Chu-Yen Lee, An-Chun Wang, Pei-Shan
Published in
Frontiers in Cell and Developmental Biology
Individuals with intrauterine growth restriction (IUGR) are at an increased risk for neurodevelopmental impairment. Fetal cortical neurogenesis is a time-sensitive process in which fetal neural stem cells (NSCs) follow a distinct pattern of layer-specific neuron generation to populate the cerebral cortex. Here, we used a murine maternal hypoxia-ind...
Gao, Chao Zhang, Long Chen, Enuo Zhang, Wenzheng
Published in
Journal of the American Society of Nephrology : JASN
Adult progenitor cells presumably demonstrate clonogenicity, self-renewal, and multipotentiality, and can regenerate cells under various conditions. Definitive evidence demonstrating the existence of such progenitor cells in adult mammalian kidneys is lacking. We performed in vivo lineage tracing and thymidine analogue labeling using adult tamoxife...
Barbaro, Vanessa Orvieto, Antonio Alvisi, Gualtiero Bertolin, Marina Bonelli, Filippo Liehr, Thomas Harutyunyan, Tigran Kankel, Stefanie Joksic, Gordana Ferrari, Stefano
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Published in
Journal of cellular and molecular medicine
Human epithelial stem cells (ESCs) are characterized by long-term regenerative properties, much dependent on the tissue of origin and varying during their lifespan. We analysed such variables in cultures of ESCs isolated from the skin, conjunctiva, limbus and oral mucosa of healthy donors and patients affected by ectrodactyly-ectodermal dysplasia-c...
Knudsen, Arnon Møldrup Halle, Bo Cédile, Oriane Burton, Mark Baun, Christina Thisgaard, Helge Anand, Atul Hubert, Christopher Thomassen, Mads Michaelsen, Signe Regner
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Published in
Neuro-oncology
Glioblastomas are highly resistant to therapy, and virtually all patients experience tumor recurrence after standard-of-care treatment. Surgical tumor resection is a cornerstone in glioblastoma therapy, but its impact on cellular phenotypes in the local postsurgical microenvironment has yet to be fully elucidated. We developed a preclinical orthoto...
