Takeda, Miho Maeda, Taishi Ishihara, Tsutomu Sakamoto, Haruka Yuki, Kanae Takasaki, Naoko Nishimura, Fumihiro Yamashita, Takeshi Tanaka, Ken-ichiro Takenaga, Mitsuko
...
Published in
Pharmaceutical Research
PurposeProstaglandin E1 (PGE1) is an effective treatment for peripheral vascular diseases. The encapsulation of PGE1 in nanoparticles for its sustained-release would improve its therapeutic effect and quality of life (QOL) of patients.MethodsIn order to encapsulate PGE1 in nanoparticles prepared with a poly(lactide) homopolymer (PLA) and monomethox...
Liu, Fu-Chao Liao, Chang-Hui Chang, Yao-Wen Liou, Jiin-Tarng Day, Yuan-Ji
Published in
Biochemical Pharmacology
Sirtinol, a cell permeable six-membered lactone ring, is derived from naphthol and potent inhibitor of SIR2 and its naphtholic may have the inhibitory effects on platelets aggregation. In this study, platelet function was examined by collagen/epinephrine (CEPI) and collagen/ADP-induced closure times using the PFA-100 system reveal that CEPI-CT and ...
Ishihara, Tsutomu Takahashi, Miyuki Higaki, Megumu Takenaga, Mitsuko Mizushima, Tohru Mizushima, Yutaka
Published in
Pharmaceutical Research
PurposeProstaglandins have potent and diverse biologic activities, but their clinical application is severely restricted, mainly due to rapid inactivation in vivo. In order to modulate the pharmacokinetics of prostaglandin E1 (PGE1), we prepared biodegradable nanoparticles as a drug carrier.MethodsNanoparticles encapsulating PGE1 were prepared from...
Yamashita, Koichi Nishiyama, Tomoki Yokoyama, Takeshi Abe, Hidehiro Manabe, Masanobu
Published in
Journal of Clinical Monitoring and Computing
BackgroundsThe instability of cardiac output (CO) measured by PulseCO™ (LiDCO Ltd.) during cardiac surgery has been reported. In the present study, we investigated the effects of vasodilation by prostaglandin E1 (PGE1) on the relation between cardiac output measured by PulseCO™ and that by thermodilution.MethodsTwenty patients who underwent off-pum...
Nagai, Atsushi Kusumi, Norihiro Tsuboi, Hiromu Ishii, Kazushi Saika, Takashi Nasu, Yasutomo Kumon, Hiromi
We report on 64 patients who did not achieve erections adequate for satisfactory sexual intercourse from among a total of 243 patients who were prescribed PDE5 inhibitors for erectile dysfunction (ED). Intracavernous injection (ICI) of PGE was performed in this non-responder group. An ICI of 20 or 40 mcg of PGE1 in 1 ml saline was performed and the...
Matsuo, Ken-ichi Togo, Shinji Sekido, Hitoshi Morita, Tomoyuki Kamiyama, Masako Morioka, Daisuke Kubota, Toru Miura, Yasuhiko Tanaka, Kuniya Ishikawa, Takashi
...
Published in
Journal of Gastrointestinal Surgery
Prostaglandin E1 (PGE1) has several potential therapeutic effects, including cytoprotection, vasodilation, and inhibition of platelet aggregation. This study investigates the protective action of PGE1 against hepatic ischemia/reperfusion injury in vivo using a complementary DNA microarray. PGE1 or saline was continuously administered intravenously ...
Bentlin, Maria Regina Saito, Adriana De Luca, Ana Karina C. Bossolan, Grasiela Bonatto, Rossano César Martins, Antonio Sérgio Rugolo, Ligia Maria Suppo de Souza
Objective: To report on the use of sildenafil for pulmonary hypertension treatment of a newborn patient after cardiac surgery. Description: A female, full term newborn infant with diagnosis of double outlet right ventricle, pulmonary hypoplasia and subaortic ventricular septal defect, was submitted to Blalock surgery in the first week of life. In p...
Bentlin, Maria Regina Saito, Adriana De Luca, Ana Karina C. Bossolan, Grasiela Bonatto, Rossano César Martins, Antonio Sérgio Rugolo, Ligia Maria Suppo de Souza
Objective: To report on the use of sildenafil for pulmonary hypertension treatment of a newborn patient after cardiac surgery. Description: A female, full term newborn infant with diagnosis of double outlet right ventricle, pulmonary hypoplasia and subaortic ventricular septal defect, was submitted to Blalock surgery in the first week of life. In p...
Bentlin, Maria Regina Saito, Adriana De Luca, Ana Karina C. Bossolan, Grasiela Bonatto, Rossano César Martins, Antonio Sérgio Rugolo, Ligia Maria Suppo de Souza
Objective: To report on the use of sildenafil for pulmonary hypertension treatment of a newborn patient after cardiac surgery. Description: A female, full term newborn infant with diagnosis of double outlet right ventricle, pulmonary hypoplasia and subaortic ventricular septal defect, was submitted to Blalock surgery in the first week of life. In p...
Bentlin, Maria Regina Saito, Adriana De Luca, Ana Karina C. Bossolan, Grasiela Bonatto, Rossano César Martins, Antonio Sérgio Rugolo, Ligia Maria Suppo de Souza
Objective: To report on the use of sildenafil for pulmonary hypertension treatment of a newborn patient after cardiac surgery. Description: A female, full term newborn infant with diagnosis of double outlet right ventricle, pulmonary hypoplasia and subaortic ventricular septal defect, was submitted to Blalock surgery in the first week of life. In p...
