Hulshof, Anne-Marije Vries, Minka Verhezen, Paul Wetzels, Rick Haartmans, Mirella Olie, Renske Ten Cate, Hugo Henskens, Yvonne
Published in
Platelets
Platelet function tests (PFT), such as the Multiple Electrode Analyzer (Multiplate) and VerifyNow, show little concordance in patients using antiplatelet drugs. A major difference between these tests is the use of prostaglandin E1 (PGE1) to inhibit P2Y1-platelet-receptor activation in VerifyNow and is proposed to be of influence in the discrepancy ...
Said, Shady Zaki Nasser, Taha Abdel Ayad, Mohammad Motawi, Ahmad Tarek
Published in
Central European Journal of Urology
Introduction Erectile dysfunction (ED) is one of the most common sexual disorders worldwide affecting about 30 million men in the United States, and an estimated 100 million men worldwide. Penile duplex doppler ultrasound (PDDU) is performed using an intracavernosal injection (ICI) of a vasoactive agent to demonstrate both arterial insufficiency an...
Zheng, Fenshuang Zhang, Min Yang, Xingwei Wu, Feilong Wang, Gan Feng, Xingxing Ombati, Rose Zuo, Ruiling Yang, Canju Liu, Jun
...
Published in
Frontiers in Veterinary Science
From a survival perspective, it is hypothesized that leech saliva exhibits certain physiological effects to ensure fast blood-feeding, including analgesia, anesthesia, and anti-inflammation to stay undetected by the host and vasodilatation and anti-hemostasis to ensure a steady, rapid, and sustained blood flow to the feeding site. Many anti-hemosta...
Vari, Daniel Xiao, Wendi Behere, Shashank Spurrier, Ellen Tsuda, Takeshi Baffa, Jeanne M
Published in
Cardiology in the young
Prostaglandin E1 is used to maintain ductal patency in critical congenital heart disease (CHD). The standard starting dose of prostaglandin E1 is 0.05 µg/kg/minute. Lower doses are frequently used, but the efficacy and safety of a low-dose regimen of prostaglandin E1 has not been established. We investigated neonates with critical CHD who were star...
Su, Chenglei Fan, Xinhui Xu, Feng Wang, Jiali Chen, Yuguo
Published in
Molecular Medicine Reports
Post-cardiac arrest myocardial dysfunction (PAMD) is a leading cause of death in patients undergoing resuscitation patients following cardiac arrest (CA). Although prostaglandin E1 (PGE1) is a clinical drug used to mitigate ischemia injury, its effect on PAMD remains unknown. In the present study, the protective effects of PGE1 on PAMD were evaluat...
Novichkova, Ekaterina Chumin, Katya Eretz-Kdosha, Noy Boussiba, Sammy Gopas, Jacob Cohen, Guy Khozin-Goldberg, Inna
Published in
Nutrients
Microalgae have been considered as a renewable source of nutritional, cosmetic and pharmaceutical compounds. The ability to produce health-beneficial long-chain polyunsaturated fatty acids (LC-PUFA) is of high interest. LC-PUFA and their metabolic lipid mediators, modulate key inflammatory pathways in numerous models. In particular, the metabolism ...
Steigerwalt, Robert Davis Jr Nebbioso, Marcella
Published in
Drug discoveries & therapeutics
The authors present the use of prostaglandin E1 (PGE1) for the treatment of an acute paracentral acute middle maculopathy (PAMM). A 78-year-old white female was seen with a sudden loss of vision in her left eye (OS) to 20/200 noted upon awakening. The right eye (OD) saw 20/20. A complete eye exam was done and an ocular coherent tomography revealed ...
Kitoh, Ryosuke Nishio, Shin-Ya Usami, Shin-Ichi
Published in
Acta oto-laryngologica
Background: To date, there have been few conventional algorithms for the treatment of idiopathic sudden sensorineural hearing loss (SSNHL), as there have been only limited reports with high evidence levels.Objectives: To propose an evidence- and trend-based treatment algorithm for SSNHL.Methods: We referred not only to the evidence for each treatme...
Tang, Mingxiang Pan, Hongwei Zheng, Zhaofen Guo, Yin Peng, Jianqiang Yang, Jun Luo, Yangping He, Jin Yan, Sulan Wang, Peng
...
Published in
Bioscience reports
Prostaglandin-E1 (PGE1) is a potent vasodilator with anti-inflammatory and antiplatelet effects. However, the mechanism by which PGE1 contributes to the amelioration of cardiac injury remains unclear. The present study was designed to investigate how PGE1 protects against hypoxia/reoxygenation (H/R)-induced injuries by regulating microRNA-21-5p (mi...
Xie, Xiaomei Lu, Weibiao Chen, Yuanfang Tsang, Chi Kwan Liang, Jianye Li, Wenxian Jing, Zhen Liao, Yu Huang, Li’an
Published in
Frontiers in Neuroscience
Compensatory vascular mechanisms can restore cerebral blood flow (CBF) but fail to protect against chronic cerebral hypoperfusion (CCH)-mediated neuronal damage and cognitive impairment. Prostaglandin E1 (PGE1) is known as a vasodilator to protect against ischemic injury in animal models, but its protective role in CCH remains unclear. To determine...
