Caianiello, Carlo D’Avino, Marcellino Cavasso, Domenico Paduano, Luigi D’Errico, Gerardino
Published in
Nanomaterials
Water-in-oil (W/O) nanoemulsions stabilized by phospholipids (PLs) are increasingly exploited in a wide spectrum of applications, from pharmaceuticals to food and cosmetic formulations. In this work, we report the design and optimization of an innovative emulsion based on a mixture of phosphoethanolamine (PE) and phosphoglycerol (PG) PLs, inspired ...
quan, hongxuan kim, yongjoon lele, wu park, hee-chul yang, hyeong-cheol
Macrophage polarization has become increasingly important for the improvement of the biocompatibility of biomaterials. In this study, we coated Ti discs with phospholipids (phosphatidylserine/phosphatidylcholine [4:1 mole/mole]) by evaporating the solvent under vacuum, and observed the polarization of RAW 264.7 cells cultured on the discs. The coat...
Khan, Urooj A Parveen, Uzma Hasan, Nazeer Ahmed, Mohammad Zubair Saad, Suma Ahmad, Farhan J Jain, Gaurav K
Published in
Drug Design, Development and Therapy
Introduction Ziprasidone (ZP) is a novel atypical antipsychotic agent effective in the treatment of positive and negative symptoms of schizophrenia with low chances for extrapyramidal side effects (EPs) and cognitive deficits. ZP possesses poor oral bioavailability (~50%), short biological half-life (~2.5 h) and due to extensive first-pass metaboli...
Wang, Cheng Chen, Shaoqing Bao, Lu Liu, Xuerong Hu, Fuqiang Yuan, Hong
Published in
International Journal of Nanomedicine
Background Calcium carbonate (CC) nanoparticles have broad biomedical utilizations, owing to their multiple intrinsic merits. However, bare CC nanoparticles do not allow for the development of multifunctional devices suitable for advanced drug delivery in cancer therapy. Methods Phospholipid-modified phospholipid–CC hybrid nanoparticles were prepar...
Lemke, Rachelle A. S. Olson, Stephanie M. Morse, Kaitlin Karlen, Steven D. Higbee, Alan Beebe, Emily T. Ralph, John Coon, Joshua J. Fox, Brian G. Donohue, Timothy J.
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Published in
The Journal of Biological Chemistry
Fatty acids play many important roles in cells and also in industrial processes. Furan fatty acids (FuFAs) are present in the lipids of some plant, fish, and microbial species and appear to function as second messengers in pathways that protect cells from membrane-damaging agents. We report here the results of chemical, genetic, and synthetic biolo...
Rahamathulla, Mohamed H.V, Gangadharappa Veerapu, Gangadhar Hani, Umme Alhamhoom, Yahya Alqahtani, Ali Moin, Afrasim
Published in
AAPS PharmSciTech
Simvastatin a cholesterol-lowering agent used to treat hypercholesterolemia, coronary heart disease, and dyslipidemia. However, simvastatin (SV) has shown low oral bioavailability in GIT. The main purpose of the work was to develop proliposomal formulations to increase the oral bioavailability of SV. Film deposition on the carrier method has been u...
Markovic, Milica Ben-Shabat, Shimon Aponick, Aaron Zimmermann, Ellen M Dahan, Arik
Published in
International journal of molecular sciences
The aim of this work is to analyze relevant endogenous lipid processing pathways, in the context of the impact that lipids have on drug absorption, their therapeutic use, and utilization in drug delivery. Lipids may serve as biomarkers of some diseases, but they can also provide endogenous therapeutic effects for certain pathological conditions. Cu...
Yeo, Sooho An, Jieun Park, Changhee Kim, Dohyun Lee, Jaehwi
Published in
Pharmaceutics
This study aimed to improve the solubility and dissolution of aprepitant, a drug with poor aqueous solubility, using a phosphatidylcholine (PC)-based solid dispersion system. When fabricating the PC-based solid dispersion, we employed mesoporous microparticles, as an adsorbent, and disintegrants to improve the sticky nature of PC and dissolution of...
Michel, Miriam Dubowy, Karl-Otto Zlamy, Manuela Karall, Daniela Adam, Mark Gordian Entenmann, Andreas Keller, Markus Andreas Koch, Jakob Odri Komazec, Irena Geiger, Ralf
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Published in
Therapeutic advances in chronic disease
Patients with a Fontan circulation have altered cholesterol and lipoprotein values. We analysed small organic molecules in extended phopsholipid and acylcarnitine metabolic pathways ('metabolomes') in adult Fontan patients with a dominant left ventricle, seeking differences between profiles in baseline and Fontan circulations. In an observational m...
Brink, Lauren R Herren, Anthony W McMillen, Shasta Fraser, Karl Agnew, Michael Roy, Nicole Lönnerdal, Bo
Published in
Journal of dairy science
Milk fat globule membrane (MFGM) is a glycosylated, protein-embedded, phospholipid fraction that surrounds triglycerides in milk. Commercial bovine sources have recently come to the market as a novel food ingredient and have been added to various products, including infant formula. Considering that MFGM is a heterogeneous mixture of fat, protein, a...