Staats, Kevin Sosa, Branden R. Kuyl, Emile-Victor Niu, Yingzhen Suhardi, Vincentius Turajane, Kathleen Windhager, Reinhard Greenblatt, Matthew B. Ivashkiv, Lionel Bostrom, Mathias P. G.
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Published in
Bone & Joint Research
Aims To develop an early implant instability murine model and explore the use of intermittent parathyroid hormone (iPTH) treatment for initially unstable implants. Methods 3D-printed titanium implants were inserted into an oversized drill-hole in the tibiae of C57Bl/6 mice (n = 54). After implantation, the mice were randomly divided into three trea...
Desapogu, Rajesh Le Marchand, Gilles Smith, Rebecca Ray, Paulami Gillier, Émilie Dutertre, Stéphanie Alouini, Mehdi Tramier, Marc Huet, Sébastien Fade, Julien
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Published in
Biomedical Optics Express
We report how a recently developed polarization imaging technique, implementing micro-wave photonics and referred to as orthogonality-breaking (OB) imaging, can be adapted on a classical confocal fluorescence microscope, and is able to provide informative polarization images from a single scan of the cell sample. For instance, the comparison of the...
Maruelli, Silvia Besio, Roberta Rousseau, Julie Garibaldi, Nadia Amiaud, Jérôme Brulin, Bénédicte Layrolle, Pierre Escriou, Virginie Rossi, Antonio Trichet, Valerie
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Published in
Matrix Biology Plus
• Identification of a specific and efficient Col1a2 siRNA • Silencing of Col1a2 allows osteoblasts mineralization. • Col1a2 silencing is not impairing matrix deposition in vivo .
Chevalier, Francois Hamdi, Dounia Houria Lepleux, Charlotte Temelie, Mihaela Nicol, Anaïs Austry, Jean Baptiste Lesueur, Paul Vares, Guillaume Savu, Diana Nakajima, Tetsuo
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Published in
Technology in cancer research & treatment
Chondrosarcomas are malignant tumors of the cartilage that are chemoresistant and radioresistant to X-rays. This restricts the treatment options essential to surgery. In this study, we investigated the sensitivity of chondrosarcoma to X-rays and C-ions in vitro. The sensitivity of 4 chondrosarcoma cell lines (SW1353, CH2879, OUMS27, and L835) was d...
koča, kristian
Diplomová práce pojednává o vlivu různých degradačních médií, simulujících prostředí lidského těla, na mechanické vlastnosti kolagenních nosičů. K tomuto účelů byla vybrána tři degradační média: lidská plazma, simulovaná tělní tekutina (SBF) a fosfátový pufr (PBS). Cílem provedeného experimentu bylo zjistit, zda jejich aplikací bude dosaženo stejné...
Thorat, Alpana A. Suryanarayanan, Raj
Published in
Pharmaceutical Research
PurposeTo study the effect of mannitol or trehalose on the crystallization behavior of solutes in phosphate buffered saline (PBS) when the solutions were frozen and freeze-dried.MethodsPBS (pH 7.5 at RT) either alone, or with trehalose (5% w/v) or mannitol (1% w/v), were frozen and characterized using low temperature differential scanning calorimet...
Hung, Yi-Fang Cheng, Chia Huang, Chun-Kai Yang, Chii-Rong
Published in
Nanomaterials
The electrochemical reduction of graphene oxide (GO) is an environmentally friendly and energy-saving method for improving the characteristics of GO. However, GO films must be coated on the cathode electrode in advance when usingthis technique. Thus, the formed electrochemically reduced GO (ERGO) films can be used only as sensing or conductive mate...
Correia, Maria S Moreiras, Hugo Pereira, Francisco J C Neto, Matilde V Festas, Tiago C Tarafder, Abul K Ramalho, José S Seabra, Miguel C Barral, Duarte C
Published in
The Journal of investigative dermatology
Melanin transfer from melanocytes to keratinocytes and subsequent accumulation in the supranuclear region is a critical process in skin pigmentation and protection against UVR. We have previously proposed that the main mode of transfer between melanocytes and keratinocytes is through exo/endocytosis of the melanosome core, termed melanocore. In thi...
Asokanathan, Catpagavalli Tierney, Sharon Ball, Christina R Buckle, George Day, Ami Tanley, Simon Bristow, Adrian Markey, Kevin Xing, Dorothy Yuen, Chun-Ting
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Published in
Analytical biochemistry
ADP-ribosyltransferase activities have been observed in many prokaryotic and eukaryotic species and viruses and are involved in many cellular processes, including cell signalling, DNA repair, gene regulation and apoptosis. In a number of bacterial toxins, mono ADP-ribosyltransferase is the main cause of host cell cytotoxicity. Several approaches ha...
Schmidt-Rondon, Eric Wang, Zhenping Malkmus, Shelle A Di Nardo, Anna Hildebrand, Keith Page, Linda Yaksh, Tony L
Published in
Toxicology and applied pharmacology
Mast cell (MC) degranulation has been implicated in the side effect profile of a variety of clinically useful agents. Thus, after intrathecal delivery, formation of space-occupying, meningeally-derived masses may be related to local MC degranulation. We systematically characterized degranulating effects of opioid and nonopioid analgesics on cutaneo...
