Dunn, J B Shriver, D F Klotz, I M
Published in
Proceedings of the National Academy of Sciences of the United States of America
Excitation of oxyhemerythrin with radiation within the envelope of its strong oxygen --> iron chargetransfer band generates two Raman frequencies, at 844 cm(-1) and 500 cm(-1). These are assigned to O-O and Fe-O stretching modes. Confirmation of these assignments is provided by the observed shifts in frequency when (16)O(2) is substituted by (18)O(...
Skiba, M. Skiba-Lahiani, M. Arnaud, P.
Published in
Journal of inclusion phenomena and macrocyclic chemistry
The authors report an amphiphilic and fluorophilic β-cyclodextrinderivative synthesized (perfluoro-β-cyclodextrins: β-CD-C8F)according to a patent registered by Skiba et al. A new type of nanocapsule(PFC-NC) based on perfluoro-β-cyclodextrins was prepared in a single step bycolloidal nanoprecipitation. PFC-NC is fluorophilic carrier that could pote...
Sun, B. Chen, J.R. Hu, J.Y. Li, X.J.
The stoichiometry of dioxygen uptake of Co complexes with 4',5'-bis-(5-chloro-2-hydroxyphenylmethylideneimino)benzo-12-crown-4 (la), 4',5'-bis(2-hydroxyphenylmethylideneimino)benzo-12-crown-4(1b), 4',5'-bis-(5-methoxy-2-hydroxyphenylmethylideneimino)benzo-12-crown-4 (1c), 4',5'-bis-(5-chloro-2-hydroxyphenylmethylideneimino)benzo-15-crown-5 (2a), 4'...
van Veen, Theun Hunt, John A
Published in
Journal of tissue engineering and regenerative medicine
The use of red blood cells (RBCs) in transfusion is widespread in modern medicine. Limitations in blood transfusion have made an urgent argument for the focus on alternatives, as particular medical treatments heavily rely on the supply of donated blood. Stem cells have been successfully used in vitro to produce RBCs and researchers are currently ch...
Hu, Wenting
In chemical-looping, a fuel is oxidised by a solid metal oxide, MeO, in one reactor: (2$n+m$)MeO+C$_{n}$H$_{2m}\rightarrow$(2$n+m$)Me+$m$H$_{2}$O+$n$CO$_{2}$. The exit gas yields pure CO$_{2}$ after the steam has been condensed. The reduced metal oxide, Me, is transferred to an oxidation reactor and regenerated: Me+air$\rightarrow$MeO. Adding these...
Jia, Yi Duan, Li Li, Junbai
Published in
Advanced materials (Deerfield Beach, Fla.)
Safe and effective artificial oxygen carriers are the subject of great interest due to the problems of traditional blood transfusion and enormous demand in clinical use. In view of its unique oxygen-transport ability and normal metabolic pathways, hemoglobin is regarded as an ideal oxygen-carrying unit. With advances in nano-biotechnology, hemoglob...
Wang, Weiqi Wang, Lei Huang, Yubin Xie, Zhigang Jing, Xiabin
Published in
Chemistry, an Asian journal
A metal-organic framework (MOF)-protein conjugate, NH2 -MIL-125(Ti)-hemoglobin [MIL-125(Ti)-Hb], was synthesized by a covalent postmodification strategy. The crystalline structure was maintained after chemical and protein modification. The content of grafted Hb was tuned by the stoichiometric ratio and reached 50 wt % if the mass ratio of MIL-125(T...
Rodriguez-Brotons, Aida Bietiger, William Peronet, Claude Langlois, Allan Magisson, Jordan Mura, Carole Sookhareea, Cynthia Polard, Valerie Jeandidier, Nathalie Zal, Franck
...
Published in
Tissue engineering. Part A
Transplantation of encapsulated islets in a bioartificial pancreas is a promising alternative to free islet cell therapy to avoid immunosuppressive regimens. However, hypoxia, which can induce a rapid loss of islets, is a major limiting factor. The efficiency of oxygen delivery in an in vitro model of bioartificial pancreas involving hypoxia and co...
Wang, Ying Wang, Linli Yu, Weili Gao, Dawei You, Guoxing Li, Penglong Zhang, Shan Zhang, Jun Hu, Tao Zhao, Lian
...
Published in
Biotechnology progress
Hemoglobin (Hb)-based oxygen carriers (HBOCs) have been used as blood substitutes in surgery medicine and oxygen therapeutics for ischemic stroke. As a potent HBOC, the PEGylated Hb has received much attention for its oxygen delivery and plasma expanding ability. Two PEGylated Hbs, Euro-Hb, and MP4 have been developed for clinical trials, using hum...
Wang, Quan Zhang, Ruirui You, Guoxing Hu, Jilin Li, Penglong Wang, Ying Zhang, Jun Wu, Yan Zhao, Lian Zhou, Hong
...
Oxidative toxicity has impeded the development of haemoglobin-based oxygen carriers (HBOCs) by causing methaemoglobin (MetHb) formation and inducing oxidative stress. In our previous work, polydopamine-coated haemoglobin (Hb-PDA) nanoparticles have been designed and synthesized with the capacity to reduce oxidative toxicity. In this investigation, ...
