Rotmensch, Jacob Atcher, Robert W. Hines, John Grdina, David Schwartz, Jeffrey S. Toohill, Margaret Herbst, Arthur L.
Published in
American Journal of Obstetrics and Gynecology
α-Emitting radionuclides may be an effective alternative treatment against ovarian carcinoma because they have short half-lives and are densely ionizing, with high linear energy transfer to a depth of several cell diameters without requiring cellular oxygenation. One radionuclide that has been generated and tested in our laboratory in vitro and in ...
Petru, Edgar Tamussino, Karl Lahousen, Manfred Winter, Raimund Pickel, Hellmuth Haas, Josef
Published in
American Journal of Obstetrics and Gynecology
To determine the incidence and clinical import of lymphocysts after radical gynecologic surgery including lymphadenectomy, we reviewed the records of 173 patients with cervical cancer and 135 patients with ovarian cancer who were followed up by computed tomography. Lymphocysts were found in 35 (20%) and 43 (32%) of the patients, respectively. Patie...
Muto, Michael G. Lepisto, Eva M. Van den Abbeele, Annick D. Knapp, Robert C. Kassis, Amin I.
Published in
American Journal of Obstetrics and Gynecology
Human antimurine antibody responses interfere with CA 125 antigen determinations by crosslinking the murine antiovarian carcinoma monoclonal antibody OC 125 with the second murine radiolabeled antibody used in the CA 125 radioimmunoassay. Serial CA 125 levels in 22 patients with epithelial ovarian carcinoma undergoing either radioimmunotherapy or r...
Rubin, Stephen C. Hoskins, William J. Hakes, Thomas B. Markman, Maurie Reichman, Bonnie S. Chapman, Douglas Lewis, John L. Jr.
Published in
American Journal of Obstetrics and Gynecology
Serum CA 125 levels and surgical findings were prospectively compared in 96 secondary laparotomies performed on patients with epithelial ovarian cancer. All patients had documentation of an elevated CA 125 level (>35 U/ml) at a time when ovarian cancer was present, and thus the tumors were known to be “marker positive.” Operation was performed in 4...
Rubin, Stephen C. Finstad, Connie L. Hoskins, William J. Saigo, Patricia E. Provencher, Diane M. Federici, Mark G. Hakes, Thomas B. Markman, Maurie Reichman, Bonnie S. Lloyd, Kenneth O.
...
Published in
American Journal of Obstetrics and Gynecology
The multidrug-resistance gene, MDR1, encodes a plasma membrane glycoprotein termed P-glycoprotein that mediates active cellular efflux of certain chemotherapeutic agents. P-Glycoprotein expression was evaluated in 98 frozen tumor specimens from 57 patients with epithelial ovarian cancer by the indirect immunoperoxidase technique with monoclonal ant...
Barhabei, Vanessa M. Miller, David Scott Bauer, Kenneth D. Murad, Tariq M. Rademaker, Alfred W. Lurain, John R.
Published in
American Journal of Obstetrics and Gynecology
We investigated the prognostic significance of deoxyribonucleic acid content and proliferative activity of tumor cell populations as measured by flow cytometry of the tumor specimens from 115 women with epithelial ovarian cancer. Deoxyribonucleic acid aneuploidy was found in 87 of 115 (76%) of these cancers with a mean deoxyribonucleic acid index o...
Hunter, Verda J. Daly, Lee Helms, Michael Soper, John T. Berchuck, Andrew Clarke-Pearson, Daniel L. Bast, Robert C. Jr.
Published in
American Journal of Obstetrics and Gynecology
Fifty-four patients with advanced epithelial ovarian cancer were monitored with serial serum CA 125 levels after surgical cytoreduction and during multi-agent chemotherapy with cisplatin-containing regimens. CA 125 half-life of
Rodriguez, Gustavo C. Berchuck, Andrew Whitaker, Regina S. Schlossman, David Clarke-Pearson, Daniel L. Bast, Robert C. Jr.
Published in
American Journal of Obstetrics and Gynecology
Previously we have shown that epidermal growth factor acts as a mitogen for some, but not all, ovarian cancer cells in culture. In this study we examined the effect of epidermal growth factor on proliferation of normal human ovarian epithelial cells in monolayer culture. We found that epidermal growth factor stimulated twofold to fourfold increases...
Berchuck, Andrew Rodriguez, Gustavo C. Kamel, Ahmed Dodge, Richard K. Soper, John T. Clarke-Pearson, Daniel L. Bast, Robert C. Jr.
Published in
American Journal of Obstetrics and Gynecology
Previous studies in breast and bladder cancer have suggested that epidermal growth factor receptor is expressed by only a proportion of cancers and is associated with poor clinical outcome. We used a monoclonal antibody specifically reactive with the extracellular domain of the epidermal growth factor receptor to localize this receptor immunohistoc...
Gerhardt, Robert T. Perras, James P. Sevin, Bernd-Uwe Petru, Edgar Ramos, Reinaldo Guerra, Lucy Averette, Hervy E.
Published in
American Journal of Obstetrics and Gynecology
We report the in vitro chemosensitivity of primary and recurrent human ovarian tumor samples analyzed by adenosine triphosphate chemosensitivity assay. We defined sensitivity as a ≥70% decrease in intracellular adenosine triphosphate versus control at 20% of the reported peak plasma concentration per agent tested. Twenty of 21 assays (95.24%) were ...
