Optical measurements of the cervical transformation zone (sometimes referred to as the transition zone) using elastic-scattering spectroscopy, demonstrate sensitivity to the epithelial cell-type differences. ©2004 Copyright SPIE - The International Society for Optical Engineering.
Local and superficial optical property characterization of biological tissues can be performed by measuring spatially-resolved diffuse reflectance at small source-detector separations. Monte Carlo simulations and experiments were performed to assess the performance of a spatially-resolved reflectance probe, employing multiple detector fibers (0.3 t...
Burn depth determination is a critical factor in the treatment of thermal injury. We have developed a technique, polarization sensitive optical coherence tomography (PS-OCT), to assess burn depth non-invasively. Thermal injury denatures collagen in human skin. PS-OCT is able to measure the resulting reduction in collagen birefringence using depth r...
An assessment of burn depth is a key step in guiding the treatment of patients who have sustained thermal injuries. Polarization-sensitive optical coherence tomography (PS-OCT) might eventually provide the physician with a quantitative estimate of actual burn depth. Burns of various depths were induced by contacting rat skin with a brass rod prehea...
An assessment of burn depth is a key step in guiding the treatment of patients who have sustained thermal injuries. Polarization-sensitive optical coherence tomography (PS-OCT) might eventually provide the physician with a quantitative estimate of actual burn depth. Burns of various depths were induced by contacting rat skin with a brass rod prehea...
Published in Proceedings of the National Academy of Sciences of the United States of America
Fourier transform infrared (FTIR) spectroscopy provides a unique molecular fingerprint of tissue from endogenous sources of light absorption; however, specific molecular components of the overall FTIR signature of precancer have not been characterized. In attenuated total reflectance mode, infrared light penetrates only a few microns of the tissue ...
