Raffeiner, Philipp Hart, Jonathan R. García-Caballero, Daniel Bar-Peled, Liron Weinberg, Marc S. Vogt, Peter K.
Published in
Proceedings of the National Academy of Sciences of the United States of America
MYC controls the transcription of large numbers of long noncoding RNAs (lncRNAs). Since MYC is a ubiquitous oncoprotein, some of these lncRNAs probably play a significant role in cancer. We applied CRISPR interference (CRISPRi) to the identification of MYC-regulated lncRNAs that are required for MYC-driven cell proliferation in the P493-6 and RAMOS...
Das, Basudeb Jain, Neha Mallick, Bibekanand
Published in
Biology of the cell
Piwi-interacting RNAs (piRNAs) are a novel class of ∼23-36 nts long endogenous small non-coding RNAs, earlier known to maintain germline genome integrity during development by regulating transposable elements. Recently, piRNAs are known to regulate cell proliferation, apoptosis and metastasis in different cancer cells. However, piRNAs have not yet ...
Cristiano, Luigi
Eukaryotic translation elongation factor 1 delta pseudogene 3, alias EEF1DP3, is a pseudogene. This review collects the data about its DNA/RNA and on the diseases where it is involved.
Chen, Wenjun Song, Jing Bian, Hongjun Yang, Xia Xie, Xiaoyu Zhu, Qiang Qin, Chengyong Qi, Jianni
Published in
Journal of cellular and molecular medicine
Cancer is a major health problem worldwide. An increasing number of researchers are studying the diagnosis, therapy and mechanisms underlying the development and progression of cancer. The study of noncoding RNA has attracted a lot of attention in recent years. It was found that frequent alterations of miRNA expression not only have various functio...
Barros, Silvana P Fahimipour, Farahnaz Tarran, Robert Kim, Steven Scarel-Caminaga, Raquel Mantuaneli Justice, Anne North, Kari
Published in
Periodontology 2000
Periodontitis is a chronic multifactorial inflammatory disease associated with microbial dysbiosis and characterized by progressive destruction of the periodontal tissues. Such chronic infectious inflammatory disease is recognized as a major public health problem worldwide with measurable impact in systemic health. It has become evident that the per...
Qiao, Yanwei Zhao, Xuequn Liu, Jun Yang, Wenjie
Published in
Bioengineered
Epstein-Barr virus (EBV) is an oncogenic virus that infects more than 90% of the world's population. The proteins and miRNAs encoded by EBV are involved in multiple human malignancies. Recently R-resistance RNA-seq demonstrated that EBV-encoded circular RNAs. The current research aims to explore their functions in EBV-associated malignancies. Total...
Uleri, Elena Piu, Claudia Caocci, Maurizio Ibba, Gabriele Sanges, Francesca Pira, Giovanna Murgia, Luciano Barmina, Michele Giannecchini, Simone Porcu, Alberto
...
Published in
International Journal of Molecular Sciences
The JC polyomavirus (JCV) has been repeatedly but discordantly detected in healthy colonic mucosa, adenomatous polyps, and colorectal cancer (CRC), and proposed to contribute to oncogenesis. The controversies may derive from differences in JCV targets, patient’s cohorts, and methods. Studies of simultaneous detection, quantification, and characteri...
Zheng, Zi-Hui Wu, Dong-Mei Fan, Shao-Hua Zhang, Zi-Feng Chen, Gui-Quan Lu, Jun
Published in
Journal of cellular biochemistry
Lung cancer is the main cause of cancer-related death, and the proportion of non-small cell lung cancer (NSCLC) on lung cancer is 85%, while more than 80% lung cancer patients are diagnosed with chronic obstructive pulmonary disease (COPD). In this study, we aimed to explore the potential mechanism of COPD induced NSCLC. Luciferase assay and revers...
Nurcombe, Victor Ling, Ling Hondermarck, Hubert Cool, Simon M Smith, Raymond A A
Published in
Proteomics
Increasing knowledge of how peptides bind saccharides, and of how saccharides bind peptides, is starting to revolutionize understanding of cell-extracellular matrix relationships. Here, a historical perspective is taken of the relationship between heparan sulfate glycosaminoglycans and how they interact with peptide growth factors in order to both ...
Escudie, Frédéric Van Goethem, Charles Grand, David Vendrell, Julie Vigier, Anna Brousset, Pierre Evrard, Solène Solassol, Jérôme Selves, Janick
MOTIVATION:Microsatellite instability (MSI) is a molecular marker of DNA mismatch repair deficiency frequently at play in oncogenesis. MSI testing is used for diagnostic, prognostic and therapeutic purposes in several cancers. The current gold standard analysis for microsatellite status is based on length distribution analysis of multiplex-PCR gene...
