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with nonmotor symptoms as keyword

Noradrenergic dysfunction accelerates LPS-elicited inflammation-related ascending sequential neurodegeneration and defic...

Published in Brain, behavior, and immunity

The loss of central norepinephrine (NE) released by neurons of the locus coeruleus (LC) occurs with aging, and is thought to be an important factor in producing the many of the nonmotor symptoms and exacerbating the degenerative process in animal models of Parkinson's disease (PD). We hypothesize that selectively depleting noradrenergic LC neurons ...

Are we listening to everything the PARK genes are telling us?

Published in The Journal of comparative neurology

The cardinal motor symptoms that define Parkinson's disease (PD) clinically have been recognized for over 200 years. That these symptoms arise following the loss of dopamine neurons in the substantia nigra has been known for the last 50. These long-established facts have fueled a broadly held expectation that degenerating dopaminergic neurons alone...

Movement disorders and nonmotor neuropsychological symptoms in children and adults with classical galactosemia.

Published in Journal of inherited metabolic disease

Although movement disorders (MDs) are known complications, the exact frequency and severity remains uncertain in patients with classical galactosemia, especially in children. We determined the frequency, classification and severity of MDs in a cohort of pediatric and adult galactosemia patients, and assessed the association with nonmotor neuropsych...

Sardinian Folk Dance for Individuals with Parkinson's Disease: A Randomized Controlled Pilot Trial.

Published in Journal of alternative and complementary medicine (New York, N.Y.)

Among different exercise models proposed for individuals with Parkinson's disease (IwPD), the popularity of traditional forms of dance is increasing. The aim of this study was to evaluate the effects of Sardinian folk dance (Ballu Sardu, BS) on functional performance and motor and nonmotor symptoms in IwPD. Single-blind, randomized controlled pilot...

Circadian rhythms and influencing factors of xerostomia among Parkinson's disease patients.

Published in Oral diseases

Parkinson's disease (PD) patients suffer from xerostomia, but limited information exists regarding associations with dysphagia, drooling, daily habits, PD characteristics, or possible circadian rhythms. A questionnaire was administered, including (a) clinical characteristics (comorbidities, prescribed medications, levodopa equivalent daily dose [LE...

Sardinian Folk Dance for Individuals with Parkinson's Disease: A Randomized Controlled Pilot Trial

Objectives: Among different exercise models proposed for individuals with Parkinson's disease (IwPD), the popularity of traditional forms of dance is increasing. The aim of this study was to evaluate the effects of Sardinian folk dance (Ballu Sardu, BS) on functional performance and motor and nonmotor symptoms in IwPD. Design: Single-blind, randomi...

Assessment of visual misperceptions in patients with Parkinson's disease using single and bistable percepts as testing t...

Published in Neurology India

Visual misperceptions (VMs) and hallucinations (VHs) often go unreported in patients with Parkinson's disease (PD). We assessed the utility of single and bistable visual percepts as testing tools for visual perceptual abnormalities in PD. To assess VM in patients with PD using single and bistable percepts as testing tools. This was a case-control s...

Music Therapy in Parkinson's Disease.

Published in Journal of the American Medical Directors Association

Parkinson's disease (PD) is a chronic progressive neurologic disorder involving degeneration of the dopaminergic system. Its clinical manifestations include motor and nonmotor symptoms. Several nonpharmacologic therapies, such as music therapy (MT), have recently been developed in order to improve the clinical manifestations of this disease. The ai...

Circadian Rest-Activity Rhythms Predict Cognitive Function in Early Parkinson's Disease Independently of Sleep.

Published in Movement disorders clinical practice

Cognitive impairment is a common and debilitating symptom of Parkinson's disease (PD), and its etiology is likely multifactorial. One candidate mechanism is circadian disruption. Although there is evidence of circadian abnormalities in PD, no studies have directly assessed their association with cognitive impairment. Investigate whether circadian r...