Lu, Jianan Luo, Yujie Mei, Shuhao Fang, Yuanjian Zhang, Jianmin Chen, Sheng
Published in
Current neuropharmacology
Melatonin is a hormone produced in and secreted by the pineal gland. Besides its role in regulating circadian rhythms, melatonin has a wide range of protective functions in the central nervous system (CNS) disorders. The mechanisms underlying this protective function are associated with the regulatory effects of melatonin on related genes and prote...
Yang, Haixiu Xu, Yanjun Shang, Desi Shi, Hongbo Zhang, Chunlong Dong, Qun Zhang, Yizheng Bai, Ziyi Cheng, Shujun Li, Xia
...
Published in
Annals of Translational Medicine
Background Drug resistance is the primary cause of failure in the treatment of cancer. Identifying signatures of chemoresistance will help to overcome this problem. Current drug resistance studies focus on protein-coding genes and ignore non-coding RNAs (ncRNAs), rendering it a challenging task to systematically identify ncRNAs involved in drug res...
Xiao, Xuewen Liu, Xixi Jiao, Bin
Published in
Frontiers in Neurology
Objective: This review summarizes recent findings on the epigenetics of Alzheimer's disease (AD) and provides therapeutic strategies for AD. Methods: We searched the following keywords: “genetics,” “epigenetics,” “Alzheimer's disease,” “DNA methylation,” “DNA hydroxymethylation,” “histone modifications,” “non-coding RNAs,” and “therapeutic strategi...
Meng, Lingjiao Ding, Pingan Liu, Sihua Li, Ziyi Sang, Meixiang Shan, Baoen
Published in
Annals of Translational Medicine
Circular RNA (circRNA), as a cluster of endogenous non-coding RNA (ncRNA) with tissue-specific expression in various eukaryotic species, may be involved in a variety of human physiological and pathological processes. With the continuous development of high-throughput sequencing in recent years, circRNA has been increasingly widely studied and becom...
Patty, Benjamin J. Hainer, Sarah J.
Published in
Biology
Eukaryotic genomes are pervasively transcribed, producing both coding and non-coding RNAs (ncRNAs). ncRNAs are diverse and a critical family of biological molecules, yet much remains unknown regarding their functions and mechanisms of regulation. ATP-dependent nucleosome remodeling complexes, in modifying chromatin structure, play an important role...
Huang, Cheng-Kai Bär, Christian Thum, Thomas
Published in
Frontiers in Pharmacology
Oligonucleotide-based therapies are currently gaining attention as a new treatment option for relatively rare as well as common diseases such as cardiovascular disease. With the remarkable progression of new sequencing technologies, a further step towards personalized precision medicine to target a disease at a molecular level was taken. Such thera...
Cao, Ming-xin Tang, Ya-ling Zhang, Wei-long Tang, Ya-Jie Liang, Xin-hua
Published in
Frontiers in Oncology
Non-coding RNAs (ncRNAs), which do not encode proteins, have pivotal roles in manipulating gene expression in development, physiology, and pathology. Emerging data have shown that ncRNAs can regulate lymphangiogenesis, which refers to lymphatics deriving from preexisting vessels, becomes established during embryogenesis, and has a close relationshi...
Kataoka, Naoyuki Mayeda, Akila Ohno, Kinji
Published in
Frontiers in Molecular Biosciences
Izquierdo, Andrea G. Crujeiras, Ana B.
Published in
Frontiers in Endocrinology
Objective: In recent years, an increasing number of studies have begun focusing on epigenetics as a link between environmental factors and a greater predisposition to the development of obesity and its comorbidities. An important challenge in this field is the evaluation of the possibility of the reversal of obesity-related epigenetic marks by mean...
Mustafin, R. N.
Published in
Molecular Genetics, Microbiology and Virology
AbstractThe activation of mobile genetic elements is a prerequisite for controlling the expression of genes in successive cell divisions, with their change specifically depending on the tissue and developmental stage. These activation patterns are characteristic of totipotent and pluripotent embryo cells, as well as for stem cells in the postnatal ...
